| EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortiondagger. | EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†.
Hua R, Mo Y, Lin X, Zhang B, He M, Huang C, Huang Y, Li J, Wan J, Qin H, Xie Q, Zeng D, Sun Y. | 03/18/2024 |
| Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension. | Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
Crnkovic S, Rittchen S, Jandl K, Gindlhuber J, Zabini D, Mutgan AC, Valzano F, Boehm PM, Hoetzenecker K, Toller W, Veith C, Heinemann A, Schermuly RT, Olschewski A, Marsh LM, Kwapiszewska G. | 01/28/2023 |
| Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake. | Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
Xu C, Gu L, Kuerbanjiang M, Jiang C, Hu L, Liu Y, Xue H, Li J, Zhang Z, Xu Q., Free PMC Article | 01/14/2023 |
| Insulin induces insulin receptor degradation in the liver through EphB4. | Insulin induces insulin receptor degradation in the liver through EphB4.
Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P. | 10/8/2022 |
| EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. | EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S, Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, Joshi M, Heasley LE, Ferris RL, Rodriguez O, Albanese C, Kapoor M, Pasquale EB, Karam SD., Free PMC Article | 06/25/2022 |
| Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells. | Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
Chen D, Hughes ED, Saunders TL, Wu J, Vasquez MNH, Makinen T, King PD., Free PMC Article | 04/2/2022 |
| Mutations in EPHB4 cause human venous valve aplasia. | Mutations in EPHB4 cause human venous valve aplasia.
Lyons O, Walker J, Seet C, Ikram M, Kuchta A, Arnold A, Hernández-Vásquez M, Frye M, Vizcay-Barrena G, Fleck RA, Patel AS, Padayachee S, Mortimer P, Jeffery S, Berland S, Mansour S, Ostergaard P, Makinen T, Modarai B, Saha P, Smith A., Free PMC Article | 03/19/2022 |
| Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke. | Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
Wang J, Zhang Z, Fu S, Li X, Li X, Wang S, Yuan L., Free PMC Article | 01/22/2022 |
| Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary. | Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
Alam J, Ogawa K. | 01/15/2022 |
| Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease. | Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
Piffko A, Broggini T, Harms C, Adams RH, Vajkoczy P, Czabanka M., Free PMC Article | 09/11/2021 |
| Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development. | Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development.
Gofur MR, Alam J, Ogawa K. | 07/10/2021 |
| EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. | EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
Frye M, Stritt S, Ortsäter H, Hernandez Vasquez M, Kaakinen M, Vicente A, Wiseman J, Eklund L, Martínez-Torrecuadrada JL, Vestweber D, Mäkinen T., Free PMC Article | 02/27/2021 |
| Ephrin-B2-EphB4 communication mediates tumor-endothelial cell interactions during hematogenous spread to spinal bone in a melanoma metastasis model. | Ephrin-B2-EphB4 communication mediates tumor-endothelial cell interactions during hematogenous spread to spinal bone in a melanoma metastasis model.
Broggini T, Piffko A, Hoffmann CJ, Ghori A, Harms C, Adams RH, Vajkoczy P, Czabanka M. | 12/12/2020 |
| EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells. | EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells.
Sagar V, Vatapalli R, Lysy B, Pamarthy S, Anker JF, Rodriguez Y, Han H, Unno K, Stadler WM, Catalona WJ, Hussain M, Gill PS, Abdulkadir SA., Free PMC Article | 09/12/2020 |
| we have used mouse genetics, imaging and cell biology approaches to investigate how homeostasis in the adult heart is controlled by endothelial EphB4 and its ligand ephrin-B2, which are known regulators of vascular morphogenesis and arteriovenous differentiation during development. | Endothelial EphB4 maintains vascular integrity and transport function in adult heart.
Luxán G, Stewen J, Díaz N, Kato K, Maney SK, Aravamudhan A, Berkenfeld F, Nagelmann N, Drexler HC, Zeuschner D, Faber C, Schillers H, Hermann S, Wiseman J, Vaquerizas JM, Pitulescu ME, Adams RH., Free PMC Article | 05/16/2020 |
| Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation | Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.
Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT., Free PMC Article | 08/31/2019 |
| Inhibition of Akt1 function abolishes Eph-B-mediated venous remodeling suggesting that Eph-B4 regulates arteriovenous fistula venous adaptation through an Akt1-mediated mechanism. | Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency.
Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A., Free PMC Article | 07/6/2019 |
| ephrinB2/EphB4 signaling is a key regulator of intussusceptive angiogenesis; EphB4 does not affect VEGF-R2 activation or internalization, but regulates its downstream signaling through p-ERK1/2 | EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF.
Groppa E, Brkic S, Uccelli A, Wirth G, Korpisalo-Pirinen P, Filippova M, Dasen B, Sacchi V, Muraro MG, Trani M, Reginato S, Gianni-Barrera R, Ylä-Herttuala S, Banfi A., Free PMC Article | 04/20/2019 |
| Production of inflammatory cytokines was inhibited by Ti particles through bidirectional signals. Addition of ephB4Fc inhibited the osteoclastmediated formation of Ti particles via bidirectional ephrinB2/ephB4 signaling. Activation of this bidirectional signaling pathway may be a potential clinical treatment for osteolysis surrounding prostheses. | Titanium particle‑mediated osteoclastogenesis may be attenuated via bidirectional ephrin‑B2/eph‑B4 signaling in vitro.
Ge YW, Liu ZQ, Sun ZY, Yu DG, Feng K, Zhu ZA, Mao YQ., Free PMC Article | 11/10/2018 |
| These findings implicate a molecular disinhibitory mechanism driving the establishment of perisomatic inhibition whereby visual experience enhances Pten signalling, resulting in the suppression of EphB4 expression; this relieves a native synaptic repulsion between PV cells and pyramidal neurons, thereby promoting the assembly of perisomatic inhibition. | Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex.
Baohan A, Ikrar T, Tring E, Xu X, Trachtenberg JT., Free PMC Article | 09/1/2018 |
| As endothelial progenitor cells (EPCs)derived from mouse bone marrow were cultured on substrates of increasing stiffness, the mRNA and protein levels of the specific arterial endothelial cell marker ephrinB2 were found to increase, while the expression of the venous marker EphB4 decreased | Substrate stiffness regulates arterial-venous differentiation of endothelial progenitor cells via the Ras/Mek pathway.
Xue C, Zhang T, Xie X, Zhang Q, Zhang S, Zhu B, Lin Y, Cai X. | 12/9/2017 |
| EPHB4 is a critical regulator of early lymphatic vascular development; mutations in the gene can cause an autosomal dominant form of LRHF that is associated with a high mortality rate | EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.
Martin-Almedina S, Martinez-Corral I, Holdhus R, Vicente A, Fotiou E, Lin S, Petersen K, Simpson MA, Hoischen A, Gilissen C, Jeffery H, Atton G, Karapouliou C, Brice G, Gordon K, Wiseman JW, Wedin M, Rockson SG, Jeffery S, Mortimer PS, Snyder MP, Berland S, Mansour S, Makinen T, Ostergaard P., Free PMC Article | 09/30/2017 |
| These results identify EPHB4/ephrin B2 signaling as critical to Hematopoietic stem and progenitor cells mobilization from bone marrow | Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow.
Kwak H, Salvucci O, Weigert R, Martinez-Torrecuadrada JL, Henkemeyer M, Poulos MG, Butler JM, Tosato G., Free PMC Article | 09/2/2017 |
| EphB4 plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 can be effectively compensated, most possibly by other ephrins with similar chemical structures | Disturbed Expression of EphB4, but Not EphrinB2, Inhibited Bone Regeneration in an In Vivo Inflammatory Microenvironment.
Shen LL, Zhang LX, Wang LM, Zhou RJ, Yang CZ, Zhang J, Yang PS., Free PMC Article | 08/5/2017 |
| Eph-B4 stimulates eNOS phosphorylation in vitro and may mediate vein graft adaptation by regulation of eNOS activity in vivo. | Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.
Wang M, Collins MJ, Foster TR, Bai H, Hashimoto T, Santana JM, Shu C, Dardik A., Free PMC Article | 05/20/2017 |