| our data indicate that 4.1B is an important regulator during EMT progression in melanoma cells, which may present a potential target for the prevention and treatment of melanoma. | Protein 4.1B Suppresses Tumor Metastasis by Regulating Epithelial-mesenchymal Transition Progression in Melanoma Cells.
Wang C, Li K, Men Y, Ding C, Du J, Liang T, Ji Z, Chen L, Wang T, Kang Q., Free PMC Article | 12/7/2019 |
| This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6. | Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
Kamijo A, Saitoh Y, Ohno N, Ohno S, Terada N. | 12/17/2016 |
| findings document novel, isoform-selective roles for 130-kDa 4.1B in adhesion, spreading, and migration of MEF cells by affecting actin organization | A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization.
Wang J, Song J, An C, Dong W, Zhang J, Yin C, Hale J, Baines AJ, Mohandas N, An X., Free PMC Article | 04/26/2014 |
| The results of this study demonstrated that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness. | The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.
Einheber S, Meng X, Rubin M, Lam I, Mohandas N, An X, Shrager P, Kissil J, Maurel P, Salzer JL., Free PMC Article | 06/1/2013 |
| in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber. | Protein 4.1B contributes to the organization of peripheral myelinated axons.
Cifuentes-Diaz C, Chareyre F, Garcia M, Devaux J, Carnaud M, Levasseur G, Niwa-Kawakita M, Harroch S, Girault JA, Giovannini M, Goutebroze L., Free PMC Article | 06/9/2012 |
| Protein 4.1B plays a key role in ensuring the proper molecular compartmentalization of hemi-node-type region of axons of motor neurons. | Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M., Free PMC Article | 04/21/2012 |
| 4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton. | The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.
Buttermore ED, Dupree JL, Cheng J, An X, Tessarollo L, Bhat MA., Free PMC Article | 08/27/2011 |
| 4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development. | Protein 4.1 expression in the developing hair cells of the mouse inner ear.
Okumura K, Mochizuki E, Yokohama M, Yamakawa H, Shitara H, Mburu P, Yonekawa H, Brown SD, Kikkawa Y. | 03/15/2010 |
| In this study, the expression of 4.1B and its interaction with tumor suppressor in lung cancer-1 were examined in rodent adrenal gland, and the involvement of 4.1B in tumorigenesis | Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1.
Ohno N, Terada N, Komada M, Saitoh S, Costantini F, Pace V, Germann PG, Weber K, Yamakawa H, Ohara O, Ohno S. | 01/21/2010 |
| We propose that the 4.1B-containing membrane skeleton may play a role in regulating the Na(+) and HCO(3)(-) reabsorption in S1-S2 proximal tubules. | Interaction of membrane skeletal protein, protein 4.1B and p55, and sodium bicarbonate cotransporter1 in mouse renal S1-S2 proximal tubules.
Terada N, Ohno N, Saitoh S, Seki G, Komada M, Suzuki T, Yamakawa H, Soleimani M, Ohno S. | 01/21/2010 |
| suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease | Protein 4.1B suppresses prostate cancer progression and metastasis.
Wong SY, Haack H, Kissil JL, Barry M, Bronson RT, Shen SS, Whittaker CA, Crowley D, Hynes RO., Free PMC Article | 01/21/2010 |
| 4.1B regulates mammary epithelial cell proliferation during pregnancy and suggest that its loss may influence mammary carcinoma pathogenesis | Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation.
Kuns R, Kissil JL, Newsham IF, Jacks T, Gutmann DH, Sherman LS. | 01/21/2010 |
| protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells | Immunolocalization of protein 4.1B/DAL-1 during neoplastic transformation of mouse and human intestinal epithelium.
Ohno N, Terada N, Murata S, Yamakawa H, Newsham IF, Katoh R, Ohara O, Ohno S. | 01/21/2010 |
| 4.1B gene is not required for normal development and 4.1B/Dal-1 does not function as a tumor suppressor gene | Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer.
Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL., Free PMC Article | 01/21/2010 |
| Protein 4.1B is localized in islets of Langerhans and may have a role in phenotypic transition from pancreatic adenoma to carcinoma. | Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis.
Terada N, Ohno N, Yamakawa H, Baba T, Fujii Y, Christofori G, Ohara O, Ohno S. | 01/21/2010 |