| Integrin beta3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice. | Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.
Lopuch AJ, Swinehart BD, Widener EL, Holley ZL, Bland KM, Handwerk CJ, Brett CA, Cook HN, Kalinowski AR, Rodriguez HV, Song MI, Vidal GS., Free PMC Article | 05/14/2022 |
| Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1. | Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1.
Klofas LK, Short BP, Zhou C, Carson RP., Free PMC Article | 08/7/2021 |
| Study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area. | Emx1 Is Required for Neocortical Area Patterning.
Stocker AM, O'Leary DD., Free PMC Article | 07/30/2016 |
| Study shows that in mice on the C57Bl/6 background EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1, cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum. | EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex.
Lim JW, Donahoo AL, Bunt J, Edwards TJ, Fenlon LR, Liu Y, Zhou J, Moldrich RX, Piper M, Gobius I, Bailey TL, Wray NR, Kessaris N, Poo MM, Rubenstein JL, Richards LJ., Free PMC Article | 03/12/2016 |
| The data of this study confirmed a dorsal precursor origin for cortical EGFR+ precursors and identify a novel regional difference in the abundance of self-renewing, neurogenic precursors within the Emx1-lineage of the late gestation mouse cerebral cortex | Rostral-caudal distribution of Emx1-lineage stem/transit amplifying cells and lineage progression in embryonic cortex depend on Hedgehog signaling.
Lillien L. | 05/30/2015 |
| These results suggest that the fate of the Emx1-expressing lineage in the ischemic damaged striatum is restricted. | Emx1-expressing neural stem cells in the subventricular zone give rise to new interneurons in the ischemic injured striatum.
Wei B, Nie Y, Li X, Wang C, Ma T, Huang Z, Tian M, Sun C, Cai Y, You Y, Liu F, Yang Z. | 07/2/2011 |
| analysis of the mouse neocortical subependymal cell origin and the roles of Emx1 and GAD67 | Origin of the neocortical subependymal cells speculated by Emx1 and GAD67 expression.
Tamamaki N. | 01/21/2010 |
| Emx1 lineage-derived cells contributed a substantial portion of GABAergic cells in the OB, including calretinin+ interneurons. This is in contrast to cortex, in which Emx1 lineage-derived cells do not differentiate into GABAergic neurons. | A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.
Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein JL, Alvarez-Buylla A., Free PMC Article | 01/21/2010 |
| The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development. | Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.
Bishop KM, Garel S, Nakagawa Y, Rubenstein JL, O'Leary DD. | 01/21/2010 |
| Emx1 and Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof | Emx1 and Emx2 cooperate in initial phase of archipallium development.
Shinozaki K, Yoshida M, Nakamura M, Aizawa S, Suda Y. | 01/21/2010 |
| Emx1 knockout mice displayed less anxiety-like behavior in the elevated plus maze and dark/light exploration test and less depression-like response to the forced swimming test. The acoustic startle prepulse inhibition was reduced. | Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice.
Cao BJ, Li Y. | 01/21/2010 |
| Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double knockout mice | Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.
Shinozaki K, Miyagi T, Yoshida M, Miyata T, Ogawa M, Aizawa S, Suda Y. | 01/21/2010 |
| Our data suggest that deletion of the Emx1 gene reduces hippocampal neurogenesis and affects higher motor function that requires extensive learning. | Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice.
Hong SM, Liu Z, Fan Y, Neumann M, Won SJ, Lac D, Lum X, Weinstein PR, Liu J. | 01/21/2010 |
| Expression levels of Emx1 and Emx2 restrict the prospective embryonic choroid plexus territory. | The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate.
von Frowein J, Wizenmann A, Götz M. | 01/21/2010 |