| Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model. | Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model.
Längst N, Adler J, Kuret A, Peter A, Ruth P, Boldt K, Lukowski R., Free PMC Article | 04/30/2022 |
| Depleting CRP4 is incompatible with a proper cardiac development and function. CRP4 is a novel antiremodeling factor regulated, at least to some extent, by cardiac cGMP. | Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts.
Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, Desch M, Feil R, Feil S, Nemer M, Ueffing M, Ruth P, Just S, Lukowski R. | 09/9/2017 |
| Backbone cyclization provides a means for engineeringalpha-defensins to improve their biological activity while providing excellent stability to serum degradation and highlighting the potential of peptide scaffolds for development of novel compounds. | Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.
Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA., Free PMC Article | 01/28/2012 |
| bactericidal activity predominantly affects noncommensal bacteria | Bactericidal activity of mouse α-defensin cryptdin-4 predominantly affects noncommensal bacteria.
Masuda K, Sakai N, Nakamura K, Yoshioka S, Ayabe T. | 08/20/2011 |
| Lys-for-Arg replacements in cryptdin 4 attenuated bactericidal activity | Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure.
Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ., Free PMC Article | 01/21/2010 |
| Beta-sheet-containing Crp4 induces membrane permeabilization more effectively than disulfide-null Crp4 by translocating and forming transient membrane defects. | Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue.
Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E., Free PMC Article | 01/21/2010 |
| CRP4 mediates cGMP/PKG stimulation of SM-specific gene expression, and PKG plays an important role in regulating the phenotype of VSMCs | A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase.
Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. | 01/21/2010 |
| Kinetics of Crp4 translocation coupled with peptide-induced vesicle leakage are reported. | Kinetics of cryptdin-4 translocation coupled with peptide-induced vesicle leakage.
Cummings JE, Vanderlick TK. | 01/21/2010 |
| function of the conserved salt bridge in Crp4 is not linked to bactericidal activity or proteolytic stability of the mature peptide. | Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4.
Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. | 01/21/2010 |
| the prosegment of Crp4 inhibits Crp4 bactericidal activity by blocking peptide-mediated perturbation of target cell membranes | Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes.
Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Jelinek R. | 01/21/2010 |
| Crp4 disulfide arrangement confers essential protection from degradation by this critical activating proteinase, allowing antibacterial action. | Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4.
Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. | 01/21/2010 |
| MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen | Activation of Paneth cell alpha-defensins in mouse small intestine.
Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. | 01/21/2010 |
| cryptdin-1 and cryptdin-4 exhibit circadian oscillation | Mouse intestinal cryptdins exhibit circadian oscillation.
Froy O, Chapnik N, Miskin R. | 01/21/2010 |