| Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose. | Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose.
Tung HC, Kim JW, Zhu J, Li S, Yan J, Liu Q, Koo I, Koshkin SA, Hao F, Zhong G, Xu M, Wang Z, Wang J, Huang Y, Xi Y, Cai X, Xu P, Ren S, Higashiyama T, Gonzalez FJ, Li S, Isoherranen N, Yang D, Ma X, Patterson AD, Xie W. | 10/2/2024 |
| CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity. | CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.
Wu J, Li Y, Tian S, Na S, Wei H, Wu Y, Yang Y, Shen Z, Ding J, Bao S, Liu S, Li L, Feng R, Zhu Y, He C, Yue J., Free PMC Article | 03/14/2024 |
| AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors. | AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors.
Larsen MC, Rondelli CM, Almeldin A, Song YS, N'Jai A, Alexander DL, Forsberg EC, Sheibani N, Jefcoate CR., Free PMC Article | 12/20/2023 |
| ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression. | ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
Ye G, Li J, Yu W, Xie Z, Zheng G, Liu W, Wang S, Cao Q, Lin J, Su Z, Li D, Che Y, Fan S, Wang P, Wu Y, Shen H., Free PMC Article | 09/8/2023 |
| Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium. | Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium.
Song YS, Zaitoun IS, Wang S, Darjatmoko SR, Sorenson CM, Sheibani N., Free PMC Article | 02/16/2023 |
| 6beta-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice. | 6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
Pingili AK, Jennings BL, Mukherjee K, Akroush W, Gonzalez FJ, Malik KU., Free PMC Article | 11/21/2020 |
| Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension. | Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.
Mair KM, Harvey KY, Henry AD, Hillyard DZ, Nilsen M, MacLean MR., Free PMC Article | 10/31/2020 |
| Study determined changes in the transcriptome profiles of Cyp1b1+/+ and Cyp1b1-/- retinal astrocytes (AC) by RNA sequencing and identified 585 differentially expressed genes. Results of the first report of RNA-seq investigation of the retinal AC transcriptome and the molecular pathways impacted by Cyp1b1 expression demonstrated an important role for Cyp1b1 expression in the regulation of various retinal AC functions. | Retinal astrocytes transcriptome reveals Cyp1b1 regulates the expression of genes involved in cell adhesion and migration.
Falero-Perez J, Sorenson CM, Sheibani N., Free PMC Article | 07/18/2020 |
| Ultraviolet A (UVA) induced oxidative stress, DNA damage, and estrogen-DNA adducts in mouse corneal endothelium (CE) recapitulates Fuchs endothelial corneal dystrophy (FECD). Results identified involvement of CYP1B1, the key estrogen-metabolizing enzyme, in sex-dependent differences in CE susceptibility to UVA and detected greater mtDNA damage and estrogen-DNA adduct formation in more severely affected female mice. | Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
Liu C, Miyajima T, Melangath G, Miyai T, Vasanth S, Deshpande N, Kumar V, Ong Tone S, Gupta R, Zhu S, Vojnovic D, Chen Y, Rogan EG, Mondal B, Zahid M, Jurkunas UV., Free PMC Article | 05/9/2020 |
| Cyp1b1-/- suppresses genes supported by Srebp. Gestational vitamin A deficiency (dietary retinal defiiency during pregnancy) effects distinguish Srebp1 and Srebp2 mediation. Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver. | Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development.
Maguire M, Larsen MC, Vezina CM, Quadro L, Kim YK, Tanumihardjo SA, Jefcoate CR., Free PMC Article | 05/2/2020 |
| Cyp1b1 expression in retinal astrocytes plays an important role in retinal neurovascular homeostasis. | Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation.
Falero-Perez J, Sorenson CM, Sheibani N., Free PMC Article | 02/15/2020 |
| CYP 1B1-dependent oxidative stress contributes to the neointimal growth caused by wire injury of carotid arteries of male mice. | Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.
Mukherjee K, Song CY, Estes AM, Dhodi AN, Ormseth BH, Shin JS, Gonzalez FJ, Malik KU., Free PMC Article | 11/9/2019 |
| expression has a significant impact on liver sinusoidal endothelial cells angiogenic and inflammatory functions | Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Falero-Perez J, Song YS, Zhao Y, Teixeira L, Sorenson CM, Sheibani N., Free PMC Article | 04/6/2019 |
| Hepc decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression. | Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development.
Maguire M, Larsen MC, Foong YH, Tanumihardjo S, Jefcoate CR., Free PMC Article | 04/28/2018 |
| Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07). | Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L, Waters KM, Williams DE., Free PMC Article | 09/9/2017 |
| CYP1B1 contributed to the development of Ang II-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events | Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Thirunavukkarasu S, Khan NS, Song CY, Ghafoor HU, Brand DD, Gonzalez FJ, Malik KU., Free PMC Article | 05/20/2017 |
| Miroestrol suppressed beta-naphthoflavone increases in CYP1B1. | Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in β-naphthoflavone-treated mice by miroestrol.
Chatuphonprasert W, Jarukamjorn K, Putalun W. | 05/13/2017 |
| Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy. | The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol.
Maayah ZH, Althurwi HN, El-Sherbeni AA, Abdelhamid G, Siraki AG, El-Kadi AO. | 05/13/2017 |
| Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha. | Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα.
Bushkofsky JR, Maguire M, Larsen MC, Fong YH, Jefcoate CR., Free PMC Article | 04/29/2017 |
| hypertension, and associated pathogenesis in ApoE(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids. | Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL, Estes AM, Zaidi S, Bridges D, Tso P, Gonzalez FJ, Malik KU., Free PMC Article | 04/16/2016 |
| Follicle stimulating hormone functions via p38 MAPK-induced dephosphorylation at Ser(727) of STAT1 to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles. | FSH-induced p38-MAPK-mediated dephosphorylation at serine 727 of the signal transducer and activator of transcription 1 decreases Cyp1b1 expression in mouse granulosa cells.
Du XH, Zhou XL, Cao R, Xiao P, Teng Y, Ning CB, Liu HL. | 08/15/2015 |
| Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice. | 6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.
Pingili AK, Kara M, Khan NS, Estes AM, Lin Z, Li W, Gonzalez FJ, Malik KU., Free PMC Article | 08/1/2015 |
| Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II-induced hypertension. | Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.
Jennings BL, Moore JA, Pingili AK, Estes AM, Fang XR, Kanu A, Gonzalez FJ, Malik KU., Free PMC Article | 07/25/2015 |
| Data indicaate that adduct formation in cytochrome P450 Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC). | Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.
Harper TA Jr, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE., Free PMC Article | 06/27/2015 |
| Cyp1b1 deletion substantially alters the expression of genes associated with fatty acid homeostasis | Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis.
Larsen MC, Bushkofsky JR, Gorman T, Adhami V, Mukhtar H, Wang S, Reeder SB, Sheibani N, Jefcoate CR., Free PMC Article | 06/6/2015 |