| Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury. | Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury.
Zhang ZH, Wu TY, Ju C, Zuo XS, Wang XK, Ma YG, Luo L, Zhu ZJ, Song ZW, Yao Z, Zhou J, Wang Z, Hu XY. | 08/23/2024 |
| Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation. | Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation.
Elhashani S, Glenn M, Raymant M, Schmid MC, Mielgo A. | 07/31/2024 |
| Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair. | Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair.
Feng J, Li Y, Li Y, Yin Q, Li H, Li J, Zhou B, Meng J, Lian H, Wu M, Li Y, Dou K, Song W, Lu B, Liu L, Hu S, Nie Y. | 03/29/2024 |
| Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation. | Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
Ruiz-Rodríguez MJ, Oller J, Martínez-Martínez S, Alarcón-Ruiz I, Toral M, Sun Y, Colmenar Á, Méndez-Olivares MJ, López-Maderuelo D, Kern CB, Nistal JF, Evangelista A, Teixido-Tura G, Campanero MR, Redondo JM., Free PMC Article | 01/29/2024 |
| The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors. | The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors.
Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS., Free PMC Article | 11/6/2021 |
| Versican contributes to ligament formation of knee joints. | Versican contributes to ligament formation of knee joints.
Higuchi T, Suzuki D, Watanabe T, Fanhchaksai K, Ota K, Yokoo K, Furukawa H, Watanabe H., Free PMC Article | 10/9/2021 |
| The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation. | The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation.
Harten IA, Kaber G, Agarwal KJ, Kang I, Ibarrientos SR, Workman G, Chan CK, Nivison MP, Nagy N, Braun KR, Kinsella MG, Merrilees MJ, Wight TN., Free PMC Article | 05/29/2021 |
| Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties. | Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
Han CY, Kang I, Omer M, Wang S, Wietecha T, Wight TN, Chait A., Free PMC Article | 05/22/2021 |
| Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. | Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Han CY, Kang I, Harten IA, Gebe JA, Chan CK, Omer M, Alonge KM, den Hartigh LJ, Gomes Kjerulf D, Goodspeed L, Subramanian S, Wang S, Kim F, Birk DE, Wight TN, Chait A., Free PMC Article | 05/1/2021 |
| Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation. | Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation.
Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE, Frevert CW., Free PMC Article | 03/13/2021 |
| Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. | Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML., Free PMC Article | 03/13/2021 |
| Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican. | Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.
Xue J, Chen J, Shen Q, Chan D, Li J, Tanguay AP, Schmidt TA, Niazi F, Plaas A., Free PMC Article | 03/6/2021 |
| Accumulation of versican facilitates wound healing: Implication of its initial ADAMTS-cleavage site. | Accumulation of versican facilitates wound healing: Implication of its initial ADAMTS-cleavage site.
Islam S, Chuensirikulchai K, Khummuang S, Keratibumrungpong T, Kongtawelert P, Kasinrerk W, Hatano S, Nagamachi A, Honda H, Watanabe H. | 02/13/2021 |
| GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration. | GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration.
Liu Y, Chen X, Choi YJ, Yang N, Song Z, Snedecor ER, Liang W, Leung EL, Zhang L, Qin C, Chen J., Free PMC Article | 01/23/2021 |
| C3aR knockout decreased the expression of versican in Adriamycin-treated (ADR-treated) mice. Cotreatment with ADR and suPAR specifically increased the level of versican V1 in tubulointerstitial tissues and caused more obvious interstitial fibrosis in mice than treatment with only ADR. C3a and suPAR drive versican V1 expression in tubular cells by promoting transcription and splicing, respectively. | C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis.
Han R, Hu S, Qin W, Shi J, Hou Q, Wang X, Xu X, Zhang M, Zeng C, Liu Z, Bao H., Free PMC Article | 07/4/2020 |
| different versican isoforms may act different roles in the tooth development | Expression of Different Isoforms of Versican During the Development of Mouse Mandibular First Molars.
Xu F, Cai W, Chen W, Li L, Li X, Jiang B., Free PMC Article | 06/13/2020 |
| Study of complete proteoglycanomes in the ascending aortas of normal and thoracic aortic aneurysm and dissection (TAAD) patients and in a mouse model of severe Marfan syndrome identified that massive aggrecan and versican accumulation in ascending TAAD occurs via increased synthesis and/or reduced proteolytic turnover predisposing to type-A dissections. | Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.
Cikach FS, Koch CD, Mead TJ, Galatioto J, Willard BB, Emerton KB, Eagleton MJ, Blackstone EH, Ramirez F, Roselli EE, Apte SS., Free PMC Article | 12/7/2019 |
| versican is consistently contributed by the stromal tissue, where it contributes to tumor angiogenesis | Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.
Asano K, Nelson CM, Nandadasa S, Aramaki-Hattori N, Lindner DJ, Alban T, Inagaki J, Ohtsuki T, Oohashi T, Apte SS, Hirohata S., Free PMC Article | 07/13/2019 |
| Aortas in Adamts-4-/- mice showed reduced elastic fiber destruction, versican degradation, macrophage infiltration, and apoptosis. Interestingly, Adamts-4 was directly involved in smooth muscle cell (SMC) apoptosis. Study findings indicate that Adamts-4 induces SMC apoptosis, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic aortic aneurysm and dissection development. | Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH., Free PMC Article | 07/6/2019 |
| results suggest that A-subdomain is necessary for adequate versican expression in dermis and that versican is involved in the formation of the ECM and regulation of TGFbeta signaling. | Versican A-subdomain is required for its adequate function in dermal development.
Hatano S, Nagai N, Sugiura N, Tsuchimoto J, Isogai Z, Kimata K, Ota A, Karnan S, Hosokawa Y, Watanabe H. | 04/6/2019 |
| Targeting the hyaluronan and versican content of provisional matrices in a variety of diseases including cancer is becoming an attractive strategy for intervention. (Review) | Provisional matrix: A role for versican and hyaluronan.
Wight TN., Free PMC Article | 03/3/2018 |
| Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs. | Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.
Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW., Free PMC Article | 12/9/2017 |
| Loss of Versican is associated with reduced Lung Inflammatory Response. | Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation.
Kang I, Harten IA, Chang MY, Braun KR, Sheih A, Nivison MP, Johnson PY, Workman G, Kaber G, Evanko SP, Chan CK, Merrilees MJ, Ziegler SF, Kinsella MG, Frevert CW, Wight TN., Free PMC Article | 06/3/2017 |
| Results highlight an important role for versican in regulating the expression and assembly of elastin and the phenotype of leiomyosarcoma cells. | Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo.
Keire PA, Bressler SL, Mulvihill ER, Starcher BC, Kang I, Wight TN., Free PMC Article | 12/17/2016 |
| Versican localizes to the nucleus in proliferating mesenchymal cells and suggest role in mitotic spindle organization during cell division. | Versican localizes to the nucleus in proliferating mesenchymal cells.
Carthy JM, Abraham T, Meredith AJ, Boroomand S, McManus BM. | 08/27/2016 |