| Synapse-Enriched m[6]A-Modified Malat1 Interacts with the Novel m[6]A Reader, DPYSL2, and Is Required for Fear-Extinction Memory. | Synapse-Enriched m(6)A-Modified Malat1 Interacts with the Novel m(6)A Reader, DPYSL2, and Is Required for Fear-Extinction Memory.
Madugalle SU, Liau WS, Zhao Q, Li X, Gong H, Marshall PR, Periyakaruppiah A, Zajaczkowski EL, Leighton LJ, Ren H, Musgrove MRB, Davies JWA, Kim G, Rauch S, He C, Dickinson BC, Fulopova B, Fletcher LN, Williams SR, Spitale RC, Bredy TW., Free PMC Article | 10/30/2023 |
| CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum. | CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum.
Grycel K, Larsen NY, Feng Y, Qvortrup K, Jensen PH, Fayyaz M, Madsen MG, Midtgaard J, Xu Z, Hasselholt S, Nyengaard JR. | 09/7/2023 |
| CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease. | CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
Brustovetsky T, Khanna R, Brustovetsky N., Free PMC Article | 05/19/2023 |
| Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models. | Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Brahma MM, Takahashi K, Namekata K, Harada T, Goshima Y, Ohshima T. | 08/13/2022 |
| Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4. | Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4.
Yamazaki Y, Moizumi M, Nagai J, Hatashita Y, Cai T, Kolattukudy P, Inoue T, Goshima Y, Ohshima T. | 04/9/2022 |
| Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport. | Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.
Yoshihara S, Jiang X, Morikawa M, Ogawa T, Ichinose S, Yabe H, Kakita A, Toyoshima M, Kunii Y, Yoshikawa T, Tanaka Y, Hirokawa N. | 02/19/2022 |
| Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease. | Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
Brustovetsky T, Khanna R, Brustovetsky N., Free PMC Article | 12/18/2021 |
| CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons. | CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Brustovetsky T, Khanna R, Brustovetsky N., Free PMC Article | 12/4/2021 |
| Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. | Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.
Yamazaki Y, Nagai J, Akinaga S, Koga Y, Hasegawa M, Takahashi M, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T. | 08/7/2021 |
| PKCgamma-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. | PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells.
Winkler SC, Shimobayashi E, Kapfhammer JP., Free PMC Article | 07/3/2021 |
| CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. | CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.
Ziak J, Weissova R, Jeřábková K, Janikova M, Maimon R, Petrasek T, Pukajova B, Kleisnerova M, Wang M, Brill MS, Kasparek P, Zhou X, Alvarez-Bolado G, Sedlacek R, Misgeld T, Stuchlik A, Perlson E, Balastik M., Free PMC Article | 05/8/2021 |
| Regulation of Adipogenesis and Lipid Deposits by Collapsin Response Mediator Protein 2. | Regulation of Adipogenesis and Lipid Deposits by Collapsin Response Mediator Protein 2.
Chang YH, Tsai JN, Chang SW, Hsu WT, Yang CP, Hsiao CW, Shiau MY., Free PMC Article | 01/16/2021 |
| CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury. | CRMP2 improves memory deficits by enhancing the maturation of neuronal dendritic spines after traumatic brain injury.
Sun YY, Zhu L, Sun ZL, Feng DF. | 01/2/2021 |
| Tau-tubulin kinase 1 and amyloid-beta peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. | Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Ikezu S, Ingraham Dixie KL, Koro L, Watanabe T, Kaibuchi K, Ikezu T., Free PMC Article | 12/26/2020 |
| Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury. | Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury.
Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T., Free PMC Article | 10/24/2020 |
| CRMP2 is required for the 5-HT4R-mediated growth of the axons and dendrites in embryonic hippocampal neurons. | Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice.
Agrawal L, Vimal SK, Shiga T. | 07/25/2020 |
| indicated that the genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury | Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.
Kinoshita Y, Kondo S, Takahashi K, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T. | 07/25/2020 |
| By generating and characterizing a Crmp2(S517A) knock-in mouse model, this study demonstrates that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function. | Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice.
Muha V, Williamson R, Hills R, McNeilly AD, McWilliams TG, Alonso J, Schimpl M, Leney AC, Heck AJR, Sutherland C, Read KD, McCrimmon RJ, Brooks SP, van Aalten DMF., Free PMC Article | 07/4/2020 |
| These results show that modification of CRMP2 expression and phosphorylation can influence the course of experimental autoimmune encephalomyelitis | Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
Moutal A, Kalinin S, Kowal K, Marangoni N, Dupree J, Lin SX, Lis K, Lisi L, Hensley K, Khanna R, Feinstein DL., Free PMC Article | 05/16/2020 |
| our results suggest that proper control of TGF-beta/Smads/CRMP2 signaling pathways is critical for the precise execution of neuronal morphogenesis, whose impairment eventually results in neurodevelopmental disorders | Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K., Free PMC Article | 10/26/2019 |
| that the phosphorylation of CRMP2 at Ser522 is involved in the signaling pathways that may be related to neuropsychiatric and neurodegenerative diseases and pain | Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice.
Nakamura H, Takahashi-Jitsuki A, Makihara H, Asano T, Kimura Y, Nakabayashi J, Yamashita N, Kawamoto Y, Nakamura F, Ohshima T, Hirano H, Tanaka F, Goshima Y. | 10/5/2019 |
| To evaluate the role of CRMP2 phosphorylation in amyotrophic lateral sclerosis pathogenesis, we utilized CRMP2 S522A knock-in (CRMP2(ki/ki)) mice, in which the serine residue 522 was homozygously replaced with alanine and thereby making CRMP2 no longer phosphorylatable by CDK5 or GSK3B | Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T. | 04/6/2019 |
| suppression of CRMP2 phosphorylation may be a novel therapeutic target for Parkinson's disease. | Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.
Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T. | 03/9/2019 |
| Results show that collapsin response mediator protein 2 is required for platelet derived growth factor-directed cell migration in vitro. | Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration.
Sarhan AR, Szyroka J, Begum S, Tomlinson MG, Hotchin NA, Heath JK, Cunningham DL., Free PMC Article | 01/12/2019 |
| postulate that this state forces CRMP2 toward a monomer, exposing the SUMO site and consequently, resulting in constitutive regulation of NaV1.7. | A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.
Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R., Free PMC Article | 11/24/2018 |