| Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. | Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.
Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B., Free PMC Article | 09/22/2023 |
| Heterozygosity of murine Crkl does not recapitulate behavioral dimensions of human 22q11.2 hemizygosity. | Heterozygosity of murine Crkl does not recapitulate behavioral dimensions of human 22q11.2 hemizygosity.
Yamauchi T, Kang G, Hiroi N., Free PMC Article | 02/19/2022 |
| Cell shape-based chemical screening reveals an epigenetic network mediated by focal adhesions. | Cell shape-based chemical screening reveals an epigenetic network mediated by focal adhesions.
Kanazawa T, Michida H, Uchino Y, Ishihara A, Zhang S, Tabata S, Suzuki Y, Imamoto A, Okada M. | 10/16/2021 |
| MiR-145 regulates steroidogenesis in mouse primary granulosa cells through targeting Crkl. | MiR-145 regulates steroidogenesis in mouse primary granulosa cells through targeting Crkl.
Wang S, Tang W, Ma L, Yang J, Huang K, Du X, Luo A, Shen W, Ding T, Ye S, Zhou S, Yang S, Wang S. | 08/14/2021 |
| Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis. | Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis.
Imamoto A, Ki S, Li L, Iwamoto K, Maruthamuthu V, Devany J, Lu O, Kanazawa T, Zhang S, Yamada T, Hirayama A, Fukuda S, Suzuki Y, Okada M., Free PMC Article | 03/13/2021 |
| Requirement for Crk and CrkL during postnatal lens development. | Requirement for Crk and CrkL during postnatal lens development.
Park T, Curran T. | 02/27/2021 |
| Here, we show that the Crk family of adaptor proteins, Crk and Crkl, are required for mouse lens morphogenesis but not differentiation upon Fibroblast Growth Factor stimulation. | Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X., Free PMC Article | 08/10/2019 |
| results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. | Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).
Park T, Koptyra M, Curran T., Free PMC Article | 06/3/2017 |
| both Crk and CrkL are required for the acquisition of cellular transformation by v-fos, whereas Crk plays a more prominent role than CrkL in v-ras-induced transformation. | Crk and CrkL are required for cell transformation by v-fos and v-ras.
Koptyra M, Park TJ, Curran T. | 05/28/2016 |
| The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro. | Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Hallock PT, Chin S, Blais S, Neubert TA, Glass DJ., Free PMC Article | 05/21/2016 |
| CRKL plays an important role in hepatocarcinoma cell proliferation, invasion and migration as well hepatocarcinoma malignancy and metastasis. | CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells.
Shi J, Meng L, Sun MZ, Guo C, Sun X, Lin Q, Liu S. | 02/13/2016 |
| CRKL is shown to act as a potential suppressor and to provide new insight for both the malignant behaviors of hepatocarcinoma cells and lymphatic metastasis mechanism of hepatocarcinoma. | CRKL overexpression suppresses in vitro proliferation, invasion and migration of murine hepatocarcinoma Hca-P cells.
Lin Q, Sun MZ, Guo C, Shi J, Chen X, Liu S. | 10/24/2015 |
| Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling. | CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling.
Satoh T, Torii S, Nakayama K, Nishida E. | 07/4/2015 |
| Differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal graft-versus-host disease in mice. | CRK proteins selectively regulate T cell migration into inflamed tissues.
Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK., Free PMC Article | 05/16/2015 |
| Crk1/2 and CrkL are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture. | Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB., Free PMC Article | 02/14/2015 |
| Results suggest that Crk and CrkL have critical roles in cell structure and motility by maintaining cytoskeletal integrity. | Essential roles of Crk and CrkL in fibroblast structure and motility.
Park TJ, Curran T. | 12/27/2014 |
| The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer. | CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.
Padmanabhan RA, Nirmala L, Murali M, Laloraya M., Free PMC Article | 01/7/2012 |
| Reelin-induced Dab1 tyrosine phosphorylation may generate a multifaceted signaling scaffold containing a rich array of Crk/CrkL-SH3 binding effectors | Identification of CrkL-SH3 binding proteins from embryonic murine brain: implications for Reelin signaling during brain development.
Cheerathodi M, Ballif BA., Free PMC Article | 12/17/2011 |
| Data show a critical role for Crk and Crk-L downstream from Dok-7 in presynaptic and postsynaptic differentiation. | Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ., Free PMC Article | 02/12/2011 |
| a BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice | A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
Johnson KJ, Griswold IJ, O'Hare T, Corbin AS, Loriaux M, Deininger MW, Druker BJ., Free PMC Article | 03/15/2010 |
| Crk and CrkL play essential overlapping functions in the Reelin signaling pathway. | Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Park TJ, Curran T., Free PMC Article | 01/21/2010 |
| The Crk family proteins are important downstream components of the reelin signaling pathway in the regulation of postnatal hippocampal dendritogenesis. | Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis.
Matsuki T, Pramatarova A, Howell BW., Free PMC Article | 01/21/2010 |
| These results suggest a role for CrkL in the Reelin signaling pathway to control neuronal migration. | Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL.
Yip YP, Kronstadt-O'Brien P, Capriotti C, Cooper JA, Yip JW. | 01/21/2010 |
| CrkL plays a specific role in integrin-induced migration as a downstream mediator of Src. | Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases.
Li L, Guris DL, Okura M, Imamoto A., Free PMC Article | 01/21/2010 |
| CrkL is not absolutely required for T cell development or function. | T cell development and function in CrkL-deficient mice.
Peterson AC, Marks RE, Fields PE, Imamoto A, Gajewski TF. | 01/21/2010 |