| Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin beta1/FAK/ERK Signaling. | Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
Wu JI, Lin YP, Tseng CW, Chen HJ, Wang LH., Free PMC Article | 09/5/2020 |
| In a study of mice and human skin, data strongly supports the hypothesis that a reduction of CRABP-II expression accelerates and promotes skin aging, and suggests CRABP-II as a novel target to improve the efficacy of retinoid-mediated antiaging therapies. | Cellular retinoic acid binding protein-II expression and its potential role in skin aging.
Bielli A, Scioli MG, D'Amico F, Tarquini C, Agostinelli S, Costanza G, Doldo E, Campione E, Passeri D, Coniglione F, Orlandi A., Free PMC Article | 05/23/2020 |
| The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. | Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms.
Vreeland AC, Levi L, Zhang W, Berry DC, Noy N., Free PMC Article | 03/7/2015 |
| Results show that acetylation status of CRABPII directly influences embryonic stem cell differentiation in response to retinoic acid. | SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.
Tang S, Huang G, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A, McBurney MW, Fargo DC, Hu G, Baumgart-Vogt E, Zhao Y, Li X., Free PMC Article | 11/22/2014 |
| CRABP2 controls mRNA stabilization by HuR. | Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2.
Vreeland AC, Yu S, Levi L, de Barros Rossetto D, Noy N., Free PMC Article | 10/4/2014 |
| all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma | RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.
Gyöngyösi A, Szatmari I, Pap A, Dezso B, Pos Z, Széles L, Varga T, Nagy L., Free PMC Article | 04/26/2014 |
| CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells. | CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells.
Yuan J, Tang Z, Yang S, Li K., Free PMC Article | 07/20/2013 |
| observations emphasize the important role of CRABP-II in regulating the transcriptional activity of RA through RAR, and they demonstrate that repression of this gene is critical for allowing adipogenesis to proceed | Repression of cellular retinoic acid-binding protein II during adipocyte differentiation.
Berry DC, Soltanian H, Noy N., Free PMC Article | 06/28/2010 |
| TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II. | The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression.
Dieplinger B, Schiefermeier N, Juchum-Pasquazzo M, Gstir R, Huber LA, Klimaschewski L, Vietor I. | 01/21/2010 |
| Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol. | LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.
Lane MA, Xu J, Wilen EW, Sylvester R, Derguini F, Gudas LJ., Free PMC Article | 01/21/2010 |
| Localization revealed epithelial-mesenchymal interactions, differentiation differences within the retinoic acid biosynthesis and signaling pathway, and observations on nuclear versus cytoplasmic locations of Crabp2 and RA receptors (alpha, beta, gamma). | Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.
Everts HB, Sundberg JP, King LE Jr, Ong DE. | 01/21/2010 |