| Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur. | Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur.
Campos-Ordoñez T, González-Granero S, Eudave-Patiño M, Buriticá J, Herranz-Pérez V, García-Verdugo JM, Gonzalez-Perez O. | 05/22/2023 |
| Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis. | Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis.
Jeffries MA, Obr AE, Urbanek K, Fyffe-Maricich SL, Wood TL., Free PMC Article | 10/9/2021 |
| Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. | Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments.
Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. | 06/19/2021 |
| 2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway | 2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway.
Li Y, Zhao Y, Wang Y., Free PMC Article | 12/21/2019 |
| We hypothesize that PDE1 inhibition improves working memory performance by increasing prefrontal synaptic transmission and/or postsynaptic D1 receptor signaling, by modulating prefrontal downstream second messenger levels. These data, therefore, support the use of PDE1 inhibitors as a potential approach for the treatment of cognitive dysfunction. | Targeting the dopamine D(1) receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.
Pekcec A, Schülert N, Stierstorfer B, Deiana S, Dorner-Ciossek C, Rosenbrock H., Free PMC Article | 11/2/2019 |
| CNP and RtcA fine-tune XBP1 output during ER stress | The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.
Unlu I, Lu Y, Wang X., Free PMC Article | 04/13/2019 |
| The results of this study suggested that with an appropriate reporter system Cnp activity can be used to define a proliferative subpopulation of NG2 cells committed to generate oligodendrocytes. | Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.
Tognatta R, Sun W, Goebbels S, Nave KA, Nishiyama A, Schoch S, Dimou L, Dietrich D., Free PMC Article | 01/13/2018 |
| CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP). | Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M., Free PMC Article | 11/25/2017 |
| Data show atomic-resolution details of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) catalytic domain active site. | Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, Kursula P., Free PMC Article | 10/22/2016 |
| These data provide detailed novel insight into the complex effects of natriuretic peptides and their receptors on electrical conduction in the heart. | Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart.
Azer J, Hua R, Krishnaswamy PS, Rose RA., Free PMC Article | 11/8/2014 |
| kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway | Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.
Jackson EK, Gillespie DG, Mi Z, Cheng D, Bansal R, Janesko-Feldman K, Kochanek PM., Free PMC Article | 09/27/2014 |
| The data of this study reveal that CNPase is a critically important enzyme in the 2',3'-cAMP-adenosine pathway and participates in the production of adenosine, a protective neuromodulator. | Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway.
Verrier JD, Jackson TC, Gillespie DG, Janesko-Feldman K, Bansal R, Goebbels S, Nave KA, Kochanek PM, Jackson EK., Free PMC Article | 03/29/2014 |
| Low levels of Cnp1 seen in major depressive disorder (MDD) may cause unsustainable and maladaptive molecular compensations. contributing to the disease pathophysiology. | Resilient emotionality and molecular compensation in mice lacking the oligodendrocyte-specific gene Cnp1.
Edgar NM, Touma C, Palme R, Sibille E., Free PMC Article | 04/6/2013 |
| The results indicate a role for the N-terminal domain of CNPase in mediating multiple molecular interactions and provide a starting point for detailed structure-function studies on CNPase and its N-terminal domain. | The N-terminal domain of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin.
Myllykoski M, Itoh K, Kangas SM, Heape AM, Kang SU, Lubec G, Kursula I, Kursula P. | 12/22/2012 |
| analysis of myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase active-site ligand binding and molecular conformation | Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.
Myllykoski M, Raasakka A, Han H, Kursula P., Free PMC Article | 07/28/2012 |
| The downregulation of CNPase expression in the brain may be a possible consequence of Mecp2 gene mutation | Downregulation of CNPase in a MeCP2 deficient mouse model of Rett syndrome.
Wu W, Gu W, Xu X, Shang S, Zhao Z. | 07/21/2012 |
| while OECs do not normally form myelin on olfactory nerve axons, their expression of CNPase is commensurate with their potential to form myelin when transplanted into injured peripheral nerve | CNPase expression in olfactory ensheathing cells.
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD., Free PMC Article | 04/21/2012 |
| The results of this study showed that CNP::EGFP mice were significantly more susceptible to CPZ-induced demyelination, as evaluated by MBP immunostaining, oligodendroglial progenitor cell recruitment and astroglial, microglial and nestin response. | Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination.
Millet V, Marder M, Pasquini LA. | 03/31/2012 |
| Regulation of the Cnp gene, along with the relative amount of expressed Cnp enzyme, suggests that the immortalized cell lines containing them are representative of immature oligodendrocytes. | Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines.
Pereira GB, Dobretsova A, Hamdan H, Wight PA., Free PMC Article | 03/31/2012 |
| We show that CNP is necessary for the formation of a normal inner tongue process of oligodendrocytes that myelinate small diameter axons. We also show that axonal degeneration in Cnp1 null mice is present very early in postnatal life. | Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.
Edgar JM, McLaughlin M, Werner HB, McCulloch MC, Barrie JA, Brown A, Faichney AB, Snaidero N, Nave KA, Griffiths IR. | 01/21/2010 |
| Cyclic nucleotide phosphodiesterase 1 (PDE1)is involved in the regulation of duodenal HCO(3)(-) secretion and the response to pde(2) is associated with both PDE1 and PDE3, while the response to nitric oxide is mainly modulated by PDE1. | Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse duodenum in vitro.
Hayashi M, Kita K, Ohashi Y, Aihara E, Takeuchi K. | 01/21/2010 |
| CNP is an important component of the cytoskeletal machinery that directs process outgrowth in Oligodendrocytes. | Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein.
Lee J, Gravel M, Zhang R, Thibault P, Braun PE., Free PMC Article | 01/21/2010 |
| We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice. | CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS.
Rasband MN, Tayler J, Kaga Y, Yang Y, Lappe-Siefke C, Nave KA, Bansal R. | 01/21/2010 |
| Cnp1, which encodes 2',3'-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly | Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
Lappe-Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun PE, Griffiths IR, Nave KA. | 01/21/2010 |