| Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. | Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
Piñeiro-Sabarís R, MacGrogan D, de la Pompa JL., Free PMC Article | 10/31/2024 |
| ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa. | ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa.
Dietz A, Senf K, Neuhaus EM. | 04/24/2024 |
| Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring. | Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ., Free PMC Article | 02/27/2024 |
| CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting beta-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells. | CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.
Meng P, Liu C, Li J, Fang P, Yang B, Sun W, Zhang Y., Free PMC Article | 01/10/2024 |
| Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/beta-catenin pathway. | Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/β-catenin pathway.
Xiao K, Liu C, Wang H, Hou F, Shi Y, Qian ZR, Zhang H, Deng DYB, Xie L. | 08/19/2023 |
| An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development. | An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
Gonzalez-Meljem JM, Ivins S, Andoniadou CL, Le Tissier P, Scambler P, Martinez-Barbera JP., Free PMC Article | 02/22/2023 |
| Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting beta-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis. | Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
Yang J, Miao RR, Li YN, Pan T, Wu SH, Qu XJ, Cui SX., Free PMC Article | 01/28/2023 |
| Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma. | Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.
Chen F, Yang L, Peng X, Mao M, Liu X, Song J, Hu J. | 10/22/2022 |
| CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells. | CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
Ahn S, Saha A, Clark R, Kolonin MG, DiGiovanni J. | 10/15/2022 |
| Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. | Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.
Gencer S, Döring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Müller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EPC., Free PMC Article | 06/18/2022 |
| CXCR7 ameliorates myocardial infarction as a beta-arrestin-biased receptor. | CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor.
Ishizuka M, Harada M, Nomura S, Ko T, Ikeda Y, Guo J, Bujo S, Yanagisawa-Murakami H, Satoh M, Yamada S, Kumagai H, Motozawa Y, Hara H, Fujiwara T, Sato T, Takeda N, Takeda N, Otsu K, Morita H, Toko H, Komuro I., Free PMC Article | 11/13/2021 |
| Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice. | Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice.
Sigmund EC, Baur L, Schineis P, Arasa J, Collado-Diaz V, Vranova M, Stahl RAK, Thelen M, Halin C., Free PMC Article | 09/18/2021 |
| Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy. | Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy.
Ghadge SK, Messner M, Seiringer H, Maurer T, Staggl S, Zeller T, Müller C, Börnigen D, Weninger WJ, Geyer SH, Sopper S, Krogsdam A, Pölzl G, Bauer A, Zaruba MM., Free PMC Article | 06/26/2021 |
| Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interface. | Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interface.
Quinn KE, Matson BC, Caron KM., Free PMC Article | 06/5/2021 |
| Marginal Zone Formation Requires ACKR3 Expression on B Cells. | Marginal Zone Formation Requires ACKR3 Expression on B Cells.
Radice E, Ameti R, Melgrati S, Foglierini M, Antonello P, Stahl RAK, Thelen S, Jarrossay D, Thelen M. | 05/8/2021 |
| Activation of CXCR7 alleviates cardiac insufficiency after myocardial infarction by promoting angiogenesis and reducing apoptosis. | Activation of CXCR7 alleviates cardiac insufficiency after myocardial infarction by promoting angiogenesis and reducing apoptosis.
Zhang S, Yue J, Ge Z, Xie Y, Zhang M, Jiang L. | 02/13/2021 |
| CXCR7 suppression modulates macrophage phenotype and function to ameliorate post-myocardial infarction injury. | CXCR7 suppression modulates macrophage phenotype and function to ameliorate post-myocardial infarction injury.
Zhang J, Zhang Y, Xin S, Wu M, Zhang Y, Sun L. | 12/5/2020 |
| CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-beta1/Smad2/3 signaling. | CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-β1/Smad2/3 signaling.
Kim N, Ryu H, Kim S, Joo M, Jeon HJ, Lee MW, Song IC, Kim MN, Kim JM, Lee HJ., Free PMC Article | 11/21/2020 |
| The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. | The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P., Free PMC Article | 10/24/2020 |
| CXCR7: A key neuroprotective molecule against alarmin HMGB1 mediated CNS pathophysiology and subsequent memory impairment. | CXCR7: A key neuroprotective molecule against alarmin HMGB1 mediated CNS pathophysiology and subsequent memory impairment.
Das S, Mishra KP, Chanda S, Ganju L, Singh SB. | 09/19/2020 |
| CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells. | CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.
Xu T, Yu X, Deng J, Ou S, Liu X, Wang T, Liu Y, Yang J, Tan C, Yuan J, Chen Y., Free PMC Article | 08/29/2020 |
| Findings suggested that a single Cxcl12 or Cxcr7 allele might not be sufficient to maintain the hippocampal niche functionality throughout life, and that heterozygosity might represent a susceptibility factor for memory dysfunction progression. | Knockdown of the CXCL12/CXCR7 chemokine pathway results in learning deficits and neural progenitor maturation impairment in mice.
Trousse F, Jemli A, Silhol M, Garrido E, Crouzier L, Naert G, Maurice T, Rossel M. | 07/25/2020 |
| analysis showed that interaction of SDF-1 or ITAC with CXC receptors is necessary for the regulation of crucial developmental regulators expression and that CXCR7 is involved in the control of ESC pluripotency and differentiation into mesodermal lineages. | The role of CXC receptors signaling in early stages of mouse embryonic stem cell differentiation.
Kowalski K, Brzoska E, Ciemerych MA. | 06/6/2020 |
| Absence and excess of CXCL12 cause similar interneuron motility defects. Phosphorylation regulates ACKR3-mediated scavenging independently of beta-arrestins. | ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin.
Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. | 04/11/2020 |
| ACKR3, through its regulation of CXCL12 levels, is an important regulator of axon guidance in the oculomotor system; complete loss causes oculomotor synkinesis in mice. | Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans.
Whitman MC, Miyake N, Nguyen EH, Bell JL, Matos Ruiz PM, Chan WM, Di Gioia SA, Mukherjee N, Barry BJ, Bosley TM, Khan AO, Engle EC., Free PMC Article | 03/14/2020 |