| Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway. | Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway.
Che Y, Shimizu Y, Hayashi T, Suzuki J, Pu Z, Tsuzuki K, Narita S, Shibata R, Murohara T., Free PMC Article | 07/2/2024 |
| Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells. | Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.
Otobe Y, Jeong EM, Ito S, Shinohara Y, Kurabayashi N, Aiba A, Fukada Y, Kim JK, Yoshitane H., Free PMC Article | 06/12/2024 |
| Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice. | Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice.
Deng L, Jiang H, Lin J, Xu D, Qi A, Guo Q, Li PP, Wang X, Liu JS, Fu X, Li P. | 03/28/2024 |
| Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression. | Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression.
Xing C, Zhai B, Zhang Y, Fang Y, Zhang M, Zhang C, Wang W, Ding M, Huang X, Shen B, Wang R, Song L. | 02/12/2024 |
| Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice. | Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice.
Xie X, Xu H, Shu R, Sun L, Zhang M, Hu Q, Zhu K, Li Z, Wu F., Free PMC Article | 12/27/2023 |
| CPEB4-CLOCK crosstalk during temporal lobe epilepsy. | CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
de Diego-Garcia L, Brennan GP, Auer T, Menendez-Mendez A, Parras A, Martin-Gil A, Mitra M, Ollà I, Villalba-Benito L, Gil B, Alves M, Lau K, Delanty N, Beausang A, Cryan J, Brett FM, Farrell MA, O'Brien DF, Mendez R, Carracedo-Rodríguez G, Henshall DC, Lucas JJ, Engel T. | 10/12/2023 |
| miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations. | miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations.
Vyas H, Vohra A, Upadhyay K, Thounaojam M, Jadeja R, Dalvi N, Bartoli M, Devkar R., Free PMC Article | 08/16/2023 |
| The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice. | The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Wang F, Guo L, Wu Z, Zhang T, Dong D, Wu B. | 11/12/2022 |
| Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. | Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.
Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P., Free PMC Article | 06/11/2022 |
| Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress. | Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, Dhingra R, Khatua TN, Thliveris JA, Martino TA, Kirshenbaum LA., Free PMC Article | 03/26/2022 |
| Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids. | Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Umemura Y, Koike N, Tsuchiya Y, Watanabe H, Kondoh G, Kageyama R, Yagita K., Free PMC Article | 03/5/2022 |
| Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice. | Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice.
Lang V, Ferencik S, Ananthasubramaniam B, Kramer A, Maier B., Free PMC Article | 01/22/2022 |
| Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells. | Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.
Soejima Y, Iwata N, Nakano Y, Yamamoto K, Suyama A, Nada T, Otsuka F., Free PMC Article | 01/8/2022 |
| Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice. | Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice.
Sharma R, Puckett H, Kemerling M, Parikh M, Sahota P, Thakkar M., Free PMC Article | 11/6/2021 |
| Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells. | Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.
Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S., Free PMC Article | 10/30/2021 |
| The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm. | The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm.
Gul S, Aydin C, Ozcan O, Gurkan B, Surme S, Baris I, Kavakli IH., Free PMC Article | 03/20/2021 |
| Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux. | Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux.
Zhong J, Wang B, Wu B, Shang J, Jiang N, Cui A, Chen Y, Xu X, Lu H. | 02/27/2021 |
| Nonalcoholic fatty liver disease in CLOCK mutant mice. | Nonalcoholic fatty liver disease in CLOCK mutant mice.
Pan X, Queiroz J, Hussain MM., Free PMC Article | 02/6/2021 |
| Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease. | Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease.
Reitz CJ, Alibhai FJ, de Lima-Seolin BG, Nemec-Bakk A, Khaper N, Martino TA. | 12/12/2020 |
| Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes. | Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes.
Yang S, Liu Y, Guo Y, Liu R, Qi F, Li X, Yu H, Cheng S, Wang Z. | 10/24/2020 |
| The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock(19/19) Mice With Implications for Circadian Medicine. | The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock(∆19/∆19) Mice With Implications for Circadian Medicine.
Duong ATH, Reitz CJ, Louth EL, Creighton SD, Rasouli M, Zwaiman A, Kroetsch JT, Bolz SS, Winters BD, Bailey CDC, Martino TA., Free PMC Article | 10/3/2020 |
| Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFkappaB. | Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.
Yuan G, Xu L, Cai T, Hua B, Sun N, Yan Z, Lu C, Qian R. | 09/5/2020 |
| Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBalpha/beta pathway. | Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.
Ji G, Lv K, Chen H, Wang Y, Zhang Y, Li Y, Qu L. | 09/5/2020 |
| In conclusion, the CLOCK/BMAL1 complex controls cell cycle progression at the level of G2/M transition through regulation of Cyclin B1 expression. | The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1.
Farshadi E, Yan J, Leclere P, Goldbeter A, Chaves I, van der Horst GTJ., Free PMC Article | 02/22/2020 |
| Clock is a DENR target in mouse circadian timekeeping | Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.
Castelo-Szekely V, De Matos M, Tusup M, Pascolo S, Ule J, Gatfield D., Free PMC Article | 12/7/2019 |