| Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB. | Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Rahbani JF, Bunk J, Lagarde D, Samborska B, Roesler A, Xiao H, Shaw A, Kaiser Z, Braun JL, Geromella MS, Fajardo VA, Koza RA, Kazak L. | 03/11/2024 |
| Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. | Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q, Lu Z, Xu D. | 05/17/2023 |
| Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B. | Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
Nagpal L, Kornberg MD, Albacarys LK, Snyder SH., Free PMC Article | 06/26/2021 |
| Creatine kinase B controls futile creatine cycling in thermogenic fat. | Creatine kinase B controls futile creatine cycling in thermogenic fat.
Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L., Free PMC Article | 03/20/2021 |
| Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse. | Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
Dimitrijevic A, Qin Z, Aswad DW., Free PMC Article | 10/17/2015 |
| CKB plays a key role in myotube formation by limiting myoblast fusion during myogenesis. | Creatine kinase B is necessary to limit myoblast fusion during myogenesis.
Simionescu-Bankston A, Pichavant C, Canner JP, Apponi LH, Wang Y, Steeds C, Olthoff JT, Belanto JJ, Ervasti JM, Pavlath GK., Free PMC Article | 08/8/2015 |
| BCK phosphorylation at Ser6 did not affect its enzymatic activity, but led to the appearance of the phosphorylated enzyme at the endoplasmic reticulum (ER) | Regulation of brain-type creatine kinase by AMP-activated protein kinase: interaction, phosphorylation and ER localization.
Ramírez Ríos S, Lamarche F, Cottet-Rousselle C, Klaus A, Tuerk R, Thali R, Auchli Y, Brunisholz R, Neumann D, Barret L, Tokarska-Schlattner M, Schlattner U. | 09/13/2014 |
| Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation | Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation.
Van der Zee CEEM. | 07/5/2014 |
| negative regulation of CKB by mHTT is a key event in the pathogenesis of HD and contributes to the neuronal dysfunction associated with HD. | Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease.
Lin YS, Cheng TH, Chang CP, Chen HM, Chern Y. | 07/6/2013 |
| reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment | Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, Yeh WY, Wu DR, Lin YJ, Poon PW, Cheng ML, Wang CH, Chern Y., Free PMC Article | 06/25/2011 |
| Here, we report on the coupling of CK activity to body temperature rhythm and adaptive thermoregulation | Mice lacking brain-type creatine kinase activity show defective thermoregulation.
Streijger F, Pluk H, Oerlemans F, Beckers G, Bianco AC, Ribeiro MO, Wieringa B, Van der Zee CE., Free PMC Article | 01/21/2010 |
| cytoskeletal dynamics during cell motility is coupled to on-site availability of ATP generated by CKB | Local ATP generation by brain-type creatine kinase (CK-B) facilitates cell motility.
Kuiper JW, van Horssen R, Oerlemans F, Peters W, van Dommelen MM, te Lindert MM, ten Hagen TL, Janssen E, Fransen JA, Wieringa B., Free PMC Article | 01/21/2010 |
| Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption. | Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Chang EJ, Ha J, Oerlemans F, Lee YJ, Lee SW, Ryu J, Kim HJ, Lee Y, Kim HM, Choi JY, Kim JY, Shin CS, Pak YK, Tanaka S, Wieringa B, Lee ZH, Kim HH. | 01/21/2010 |
| CK-B was expressed selective to astrocytes among glial populations, and was exclusive to inhibitory neurons among neuronal populations. | Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.
Tachikawa M, Fukaya M, Terasaki T, Ohtsuki S, Watanabe M. | 01/21/2010 |
| Brain type and mitochondrial ubiquitous CK double knockout mice have a reduced body weight, and demonstrate a severely impaired spatial learning in both a dry and a wet maze, lower nestbuilding activity and diminished acoustic startle reflex responses. | Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit.
Streijger F, Oerlemans F, Ellenbroek BA, Jost CR, Wieringa B, Van der Zee CE. | 01/21/2010 |
| In rat cerebrum and cerebellum, as in rat heart, at all ages the several cCK isoenzymes do participate in a gender-specific manner, in favor of females, in diverse functions of the different cell compartments of glial and neuronal cells. | Sexual dimorphism in rat cerebrum and cerebellum: different patterns of catalytically active creatine kinase isoenzymes during postnatal development and aging.
Ramírez O, Jiménez E. | 01/21/2010 |
| The comparison of protein patterns obtained with neural and non-neural derivatives of EC cell lines indicates changes are specific for the neural pathway, including the accumulation of the brain isozyme of creatine phosphokinase. | Two specific markers for neural differentiation of embryonal carcinoma cells.
Eddé B, Jakob H, Darmon M., Free PMC Article | 01/21/2010 |