| Loss of Lymphatic IKKalpha Disrupts Lung Immune Homeostasis, Drives BALT Formation, and Protects against Influenza. | Loss of Lymphatic IKKα Disrupts Lung Immune Homeostasis, Drives BALT Formation, and Protects against Influenza.
Cully MD, Nolte JE, Patel A, Vaughan AE, May MJ., Free PMC Article | 07/22/2024 |
| IKK1 aggravates ischemia-reperfusion kidney injury by promoting the differentiation of effector T cells. | IKK1 aggravates ischemia-reperfusion kidney injury by promoting the differentiation of effector T cells.
Song N, Xu Y, Paust HJ, Panzer U, de Las Noriega MM, Guo L, Renné T, Huang J, Meng X, Zhao M, Thaiss F., Free PMC Article | 04/21/2023 |
| Conditional loss of IKKalpha in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat. | Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat.
Davis JL, Pokhrel NK, Cox L, Rohatgi N, Faccio R, Veis DJ., Free PMC Article | 05/7/2022 |
| Deficiency of IKKalpha in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury. | Deficiency of IKKα in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury.
Zhang F, Fan L, Zhang H, Huang WJ, Sun D, Pan BB, Wan X, Cao CC., Free PMC Article | 03/12/2022 |
| IKKalpha mediates UVB-induced cell apoptosis by regulating p53 pathway activation. | IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation.
Wang H, Zhang M, Xu X, Hou S, Liu Z, Chen X, Zhang C, Xu H, Wu L, Liu K, Song L. | 11/22/2021 |
| Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation. | Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.
Fischer KC, Daunt CP, Tremblay CS, Dias S, Vince JE, Jabbour AM., Free PMC Article | 09/18/2021 |
| Inducible knockout of CHUK/IKKalpha in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. | Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
Culley KL, Lessard SG, Green JD, Quinn J, Chang J, Khilnani T, Wondimu EB, Dragomir CL, Marcu KB, Goldring MB, Otero M., Free PMC Article | 10/31/2020 |
| The data show that IKKa and IKKb regulate unique genes in pulmonary endothelial cells, resulting in differential effects on lung angiogenesis. | Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.
Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM., Free PMC Article | 11/2/2019 |
| our data reveals that IKKa is a novel mediator protecting against the development of myocardial I/R injury via negative regulation of macrophage polarization to M1 phenotype. | Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages.
Cao Y, Xu Y, Auchoybur ML, Chen W, He S, Qin W, Su C, Huang F, Qiu Z, Li L, Chen X. | 10/26/2019 |
| Data suggest a direct link between microtubule-associated protein 1-light chain 3 (LC3)-associated phagocytosis (LAP) formation and IKK alpha (IKKalpha) recruitment downstream of -like receptor 9 (TLR9) activation that is necessary to facilitate type I IFN production. | The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.
Hayashi K, Taura M, Iwasaki A., Free PMC Article | 09/21/2019 |
| Data show that IkappaB kinase (IKK) controlled thymocyte survival by repressing cell-death-inducing activity of the serine/threonine kinase RIPK1 (RIPK1). | Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.
Webb LV, Barbarulo A, Huysentruyt J, Vanden Berghe T, Takahashi N, Ley S, Vandenabeele P, Seddon B., Free PMC Article | 08/17/2019 |
| IKKalpha knockout disrupts cell differentiation and migration of marginal zone and follicular B cells. | IKKα deficiency disrupts the development of marginal zone and follicular B cells.
Balkhi MY, Willette-Brown J, Wittmann G, Hu Y., Free PMC Article | 05/18/2019 |
| Deficiency of IKKalpha prevents adenoma formation, with adenomas lacking IKKalpha showing reduced proliferation. In contrast, IKKalpha status did not affect normal intestinal function. The same divergent phenotype was found in the organoid-spheroid model. | IKKα is required in the intestinal epithelial cells for tumour stemness.
Colomer C, Margalef P, Gonzalez J, Vert A, Bigas A, Espinosa L., Free PMC Article | 04/20/2019 |
| evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. | The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.
Thomas Y, Scott DC, Kristariyanto YA, Rinehart J, Clark K, Cohen P, Kurz T., Free PMC Article | 12/29/2018 |
| Pathological activation of hepatic IKK alpha likely blocks hepatocyte replication, contributing to liver disease progression. | Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L., Free PMC Article | 11/24/2018 |
| functions as a suppressor of lung adenocarcinoma; deletion up-regulates NOX2 and down-regulates NRF2, leading to ROS accumulation and blockade of cell senescence induction | IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.
Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y., Free PMC Article | 07/21/2018 |
| By modulating the translation of IkappaBalpha via the Mnk2-eIF4E pathway, Brd4 provides an additional layer of control for NF-kappaB-dependent inflammatory gene expression and inflammatory response. | Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.
Bao Y, Wu X, Chen J, Hu X, Zeng F, Cheng J, Jin H, Lin X, Chen LF., Free PMC Article | 05/19/2018 |
| UVB-irradiated or aged mice skin revealed that mTORC2 activity was significantly upregulated which in turn increased Akt activation and Akt-dependent IkappaB kinase alpha (IKKalpha) phosphorylation, and The increased mTORC2 signaling pathway during skin aging were associated to NF-kappaB activation. | The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging.
Choi YJ, Moon KM, Chung KW, Jeong JW, Park D, Kim DH, Yu BP, Chung HY., Free PMC Article | 02/3/2018 |
| Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6. | Regional regulation of Filiform tongue papillae development by Ikkα/Irf6.
Kawasaki M, Kawasaki K, Oommen S, Blackburn J, Watanabe M, Nagai T, Kitamura A, Maeda T, Liu B, Schmidt-Ullrich R, Akiyama T, Inoue J, Hammond NL, Sharpe PT, Ohazama A. | 01/6/2018 |
| results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. | The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. | 11/25/2017 |
| IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation. | Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.
He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z., Free PMC Article | 10/14/2017 |
| IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation. | IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR., Free PMC Article | 08/19/2017 |
| Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta) can be uncoupled by quinoxaline urea analog 13-197. | A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ.
Maroni D, Rana S, Mukhopadhyay C, Natarajan A, Naramura M., Free PMC Article | 10/1/2016 |
| Hematopoietic IKKalpha deficiency in mouse suppresses Akt signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis. | Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Babaev VR, Ding L, Zhang Y, May JM, Lin PC, Fazio S, Linton MF., Free PMC Article | 08/13/2016 |
| Anatomy of a negative feedback loop: the case of IkappaBalpha. | Anatomy of a negative feedback loop: the case of IκBα.
Fagerlund R, Behar M, Fortmann KT, Lin YE, Vargas JD, Hoffmann A., Free PMC Article | 05/14/2016 |