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    Cdh2 cadherin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12558, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    N-cadherin and beta1 integrin coordinately regulate growth plate cartilage architecture.

    N-cadherin and β1 integrin coordinately regulate growth plate cartilage architecture.
    Greer SE, Haller SJ, Lee D, Dudley AT., Free PMC Article

    04/18/2024
    YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression.

    YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression.
    Xiao Y, Zhou L, Andl T, Zhang Y., Free PMC Article

    03/18/2024
    N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of beta-catenin translocation.

    N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of β-catenin translocation.
    Xiang W, Li L, Hong F, Zeng Y, Zhang J, Xie J, Shen G, Wang J, Fang Z, Qi W, Yang X, Gao G, Zhou T.

    03/28/2023
    Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.

    Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
    Nagaoka T, Katsuno T, Fujimura K, Tsuchida K, Kishi M., Free PMC Article

    03/10/2023
    Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin.

    Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin.
    Yuan D, Guo T, Qian H, Jin C, Ge H, Zhao Y, Zhu D, Lin M, Wang H, Yu H.

    01/14/2023
    ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity.

    ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity.
    Cai Z, Zhang Y, Yang L, Ma C, Fei Y, Ding J, Song W, Tong WM, Niu Y, Li H., Free PMC Article

    12/3/2022
    MicroRNA-200c/429 mediated regulation of Zeb1 augments N-Cadherin in mouse cardiac mesenchymal cells.

    MicroRNA-200c/429 mediated regulation of Zeb1 augments N-Cadherin in mouse cardiac mesenchymal cells.
    Nath AV, Ajit S, Sekar AJ, P R AK, Muthusamy S.

    04/9/2022
    Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model.

    Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model.
    Verón GL, Veiga MF, Cameo M, Marín-Briggiler CI, Vazquez-Levin MH., Free PMC Article

    03/5/2022
    Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.

    Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
    Nair TS, Kakaraparthi BN, Yang L, Lu L, Thomas TB, Morris AC, Kommareddi P, Kanicki A, Carey TE.

    03/5/2022
    N-cadherin localization in taste buds of mouse circumvallate papillae.

    N-cadherin localization in taste buds of mouse circumvallate papillae.
    Ikuta R, Myoenzono K, Wasano J, Hamaguchi-Hamada K, Hamada S, Kurumata-Shigeto M.

    01/29/2022
    CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.

    CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.
    Halperin D, Stavsky A, Kadir R, Drabkin M, Wormser O, Yogev Y, Dolgin V, Proskorovski-Ohayon R, Perez Y, Nudelman H, Stoler O, Rotblat B, Lifschytz T, Lotan A, Meiri G, Gitler D, Birk OS., Free PMC Article

    12/4/2021
    N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.

    N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
    Osuka S, Zhu D, Zhang Z, Li C, Stackhouse CT, Sampetrean O, Olson JJ, Gillespie GY, Saya H, Willey CD, Van Meir EG., Free PMC Article

    10/2/2021
    Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks.

    Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks.
    Asada-Utsugi M, Uemura K, Kubota M, Noda Y, Tashiro Y, Uemura TM, Yamakado H, Urushitani M, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A., Free PMC Article

    09/4/2021
    mGluR5 regulates REST/NRSF signaling through N-cadherin/beta-catenin complex in Huntington's disease.

    mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease.
    de Souza JM, Abd-Elrahman KS, Ribeiro FM, Ferguson SSG., Free PMC Article

    07/10/2021
    N-cadherin (Cdh2) Maintains Migration and Postmitotic Survival of Cortical Interneuron Precursors in a Cell-Type-Specific Manner.

    N-cadherin (Cdh2) Maintains Migration and Postmitotic Survival of Cortical Interneuron Precursors in a Cell-Type-Specific Manner.
    László ZI, Bercsényi K, Mayer M, Lefkovics K, Szabó G, Katona I, Lele Z., Free PMC Article

    06/12/2021
    Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.

    Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.
    Jiang D, Christ S, Correa-Gallegos D, Ramesh P, Kalgudde Gopal S, Wannemacher J, Mayr CH, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller HB, Rinkevich Y., Free PMC Article

    12/12/2020
    N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through a beta-Catenin-Dependent Manner.

    N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through a β-Catenin-Dependent Manner.
    Yan W, Lin C, Guo Y, Chen Y, Du Y, Lau WB, Xia Y, Zhang F, Su R, Gao E, Wang Y, Li C, Liu R, Ma XL, Tao L.

    11/21/2020
    Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development.

    Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development.
    Na Y, Calvo-Jiménez E, Kon E, Cao H, Jossin Y, Cooper JA., Free PMC Article

    08/22/2020
    N-Cadherin Is Critical for the Survival of Germ Cells, the Formation of Steroidogenic Cells, and the Architecture of Developing Mouse Gonads.

    N-Cadherin Is Critical for the Survival of Germ Cells, the Formation of Steroidogenic Cells, and the Architecture of Developing Mouse Gonads.
    Piprek RP, Kolasa M, Podkowa D, Kloc M, Kubiak JZ., Free PMC Article

    08/13/2020
    N-cadherin helps to propagate a stable neural identity throughout the emerging neuroepithelium, and that dysregulation of this process contributes to asynchronous differentiation in culture

    N-cadherin stabilises neural identity by dampening anti-neural signals.
    Punovuori K, Migueles RP, Malaguti M, Blin G, Macleod KG, Carragher NO, Pieters T, van Roy F, Stemmler MP, Lowell S., Free PMC Article

    07/4/2020
    Down-regulation of activity or protein level of CDK5 did not alter the total amount of NCAD proteins but lowered its surface expression in cells.

    Cdk5 regulates N-cadherin-dependent neuronal migration during cortical development.
    Lee DK, Lee H, Yoon J, Hong S, Lee Y, Kim KT, Kim JW, Song MR.

    06/20/2020
    IFN gamma reduced the expression of N-cadherin in fibroblasts, which is essential for fibroblast motility and adhesion ability. The deficiency of IFN gamma R signaling in fibroblasts increases liver metastasis of LLC tumor in vivo.

    IFNγ inhibits fibroblast-leading tumor cell invasion through downregulating N-cadherin.
    Liu X, Zhu L, Wang R, Lou X, Yao X, Ni C, Qin Z.

    04/11/2020
    Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.

    Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.
    Miao L, Li J, Li J, Lu Y, Shieh D, Mazurkiewicz JE, Barroso M, Schwarz JJ, Xin HB, Singer HA, Vincent PA, Zhong W, Radice GL, Wan LQ, Fan ZC, Huang G, Wu M., Free PMC Article

    03/28/2020
    These findings reveal novel functions for FGFRs in cortical projection neuron migration, suggest a physiological role for FGFR and N-Cadherin interaction in vivo and identify Reelin as an extracellular upstream regulator and Erk1/2 as downstream effectors of FGFRs during neuron migration.

    N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.
    Kon E, Calvo-Jiménez E, Cossard A, Na Y, Cooper JA, Jossin Y., Free PMC Article

    02/22/2020
    The N-cadherin interactome in primary cardiomyocytes has been characterized using quantitative proximity proteomics.

    The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics.
    Li Y, Merkel CD, Zeng X, Heier JA, Cantrell PS, Sun M, Stolz DB, Watkins SC, Yates NA, Kwiatkowski AV., Free PMC Article

    02/15/2020
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