| Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10. | Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10.
Goodall KJ, Nguyen A, Andrews DM, Sullivan LC., Free PMC Article | 11/27/2021 |
| Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells. | Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells.
Kojo S, Ohno-Oishi M, Wada H, Nieke S, Seo W, Muroi S, Taniuchi I., Free PMC Article | 03/13/2021 |
| Lck-CD8 interaction is required for initial CD8 recruitment. | Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR., Free PMC Article | 10/17/2015 |
| Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex. | A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W. | 06/20/2015 |
| CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a. | cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC., Free PMC Article | 03/29/2014 |
| We propose that ADP-ribosylation of CD8-beta can regulate the coreceptor function of CD8 in the presence of elevated levels of extracellular NAD(+) . | CD8-β ADP-ribosylation affects CD8(+) T-cell function.
Lischke T, Schumacher V, Wesolowski J, Hurwitz R, Haag F, Koch-Nolte F, Mittrücker HW. | 09/14/2013 |
| Data indicate that CD8low cells survive long term in vivo. | Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.
Olver S, Apte SH, Baz A, Kelso A, Kienzle N., Free PMC Article | 07/6/2013 |
| The crystal structure of CD8alphabeta in complex with H-2Dd antigen indicates that CD8beta is crucial in orienting the CD8alphabeta heterodimer. | Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.
Wang R, Natarajan K, Margulies DH., Free PMC Article | 01/21/2010 |
| Results identify novel functions for both CD8 and LAT during CD8-mediated apoptosis that are independent of TCR signal transduction and suggest a mechanism for signal transduction leading to apoptosis upon CD8 crosslinking. | A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Clarke RL, Thiemann S, Refaeli Y, Werlen G, Potter TA., Free PMC Article | 01/21/2010 |
| The stalk region of CD8beta influences the ability of CD8 to bind class I major histocompatibility complexes and is therefore critical for the correct functioning of CD8alphabeta heterodimers. | An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.
Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, Kioussis D, Zamoyska R. | 01/21/2010 |
| The crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab at 2.7 A resolution, was elucidated. | The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.
Shore DA, Issafras H, Landais E, Teyton L, Wilson IA., Free PMC Article | 01/21/2010 |
| sialylation in a discrete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental switch that affects ligand binding | Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.
Moody AM, North SJ, Reinhold B, Van Dyken SJ, Rogers ME, Panico M, Dell A, Morris HR, Marth JD, Reinherz EL. | 01/21/2010 |
| Data demonstrate that major histocompatibility complex-I-signaled thymocytes appear as CD4+8lo cells because of transient down-regulation of CD8 gene expression, not because of changes in CD8 surface protein expression or distribution. | Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.
Bosselut R, Guinter TI, Sharrow SO, Singer A., Free PMC Article | 01/21/2010 |
| The stalk region of CD8 beta is capable of fine-tuning the coreceptor function of CD8 proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region. | Stalk region of beta-chain enhances the coreceptor function of CD8.
Wong JS, Wang X, Witte T, Nie L, Carvou N, Kern P, Chang HC. | 01/21/2010 |
| results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression | Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic I, Koesters C, Unger B, Sekimata M, Hertweck A, Maschek R, Wilson CB, Ellmeier W., Free PMC Article | 01/21/2010 |