| The data show that CD3epsilon chain couples to Cbl via simultaneous binding of both proteins to Numb, thus mediating TCR degradation | CD3ε recruits Numb to promote TCR degradation.
Martin-Blanco N, Jiménez Teja D, Bretones G, Borroto A, Caraballo M, Screpanti I, León J, Alarcón B, Canelles M. | 12/17/2016 |
| IL-17-producing CD3(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation. | CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.
Paget C, Chow MT, Gherardin NA, Beavis PA, Uldrich AP, Duret H, Hassane M, Souza-Fonseca-Guimaraes F, Mogilenko DA, Staumont-Sallé D, Escalante NK, Hill GR, Neeson P, Ritchie DS, Dombrowicz D, Mallevaey T, Trottein F, Belz GT, Godfrey DI, Smyth MJ. | 12/19/2015 |
| these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling. | LAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ.
Kawai Y, Ouchida R, Yamasaki S, Dragone L, Tsubata T, Wang JY. | 02/21/2015 |
| these results indicate that membrane association of the CD3epsilon signaling domain is required for optimal thymocyte development and peripheral T cell function. | Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.
Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA., Free PMC Article | 08/23/2014 |
| These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 in Dow2-induced anergic T cells. The novel CD3-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression | Novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation.
Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J. | 07/26/2014 |
| that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. | Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.
Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B. | 04/19/2014 |
| Structure of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled structural comparisons of antibody-liganded and unliganded forms of CD3epsilon revealing that antibody binding does not induce any substantial rearrangements within CD3epsilon. | T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.
Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ., Free PMC Article | 11/24/2012 |
| CFTR dysfunction in T cells can lead directly to aberrant immune responses in CD3+ lymphocytes | Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses.
Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR., Free PMC Article | 08/27/2011 |
| analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice | Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
Ohigashi I, Yamasaki Y, Hirashima T, Takahama Y., Free PMC Article | 07/9/2011 |
| Polymorphisms of the CD3varepsilon ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 antibody binding. | Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation.
Boding L, Nielsen MW, Bonefeld CM, von Essen MR, Nielsen BL, Lauritsen JP, Hansen AK, Nielsen MM, Kongsbak M, Rubin M, Vennegaard MT, Odum N, Geisler C. | 09/20/2010 |
| the stalks of the CD3 proteins may be critical in transmitting part of the activation signal directly through the membrane. | A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.
Wang Y, Becker D, Vass T, White J, Marrack P, Kappler JW., Free PMC Article | 04/12/2010 |
| Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon. | N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains.
Bello R, Feito MJ, Ojeda G, Portolés P, Rojo JM. | 02/8/2010 |
| We demonstrate that the intra-cytoplasmic (IC) domain of CD3epsilon plays a critical role in regulating TCR expression on DP thymocytes. | Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon.
Brodeur JF, Li S, Damlaj O, Dave VP. | 02/1/2010 |
| CD3gammaepsilon dimers predominated over CD3deltaepsilon dimers at the early stage of T cell development. | Dynamics of CD3gammaepsilon and CD3deltaepsilon dimer expression during murine T cell development.
Laird RM, Hayes SM. | 01/21/2010 |
| importance of the conformational change in CD3epsilon for the activation of T cells | Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.
Martínez-Martín N, Risueño RM, Morreale A, Zaldívar I, Fernández-Arenas E, Herranz F, Ortiz AR, Alarcón B. | 01/21/2010 |
| functional role for the CD3 epsilon lipid-binding domain in T cell biology | The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.
Deford-Watts LM, Tassin TC, Becker AM, Medeiros JJ, Albanesi JP, Love PE, Wülfing C, van Oers NS., Free PMC Article | 01/21/2010 |
| have identified distinct roles for individual motifs of CD3epsilon in the preTCR-mediated differentiation and proliferation | Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation.
Brodeur JF, Li S, da Silva Martins M, Larose L, Dave VP. | 01/21/2010 |
| CD3epsilon proline-rich sequence amplifies weak TCR signals by promoting synapse formation and CD3epsilon phosphorylation | The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.
Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P., Free PMC Article | 01/21/2010 |
| CD3epsilon-mediated signal transduction pathway is essential for this transformation process | p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A., Free PMC Article | 01/21/2010 |
| mouse CD3 epsilon chains N-terminal charged residues have roles in generating isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions | Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.
Bello R, Feito MJ, Ojeda G, Portolés P, Rojo JM. | 01/21/2010 |
| inability of Nck to bind to the CD3epsilon proline-rich sequence in thymocytes after TCR ligation | The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function.
Szymczak AL, Workman CJ, Gil D, Dilioglou S, Vignali KM, Palmer E, Vignali DA. | 01/21/2010 |
| That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma. | Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation.
Montufar-Solis D, Garza T, Klein JR., Free PMC Article | 01/21/2010 |
| insulin-specific Tregs producing IL-10, TGF-beta, and IL-4 are enhanced by suppression of CD3epsilon in a mouse model of autoimmune diabetes | Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.
Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M., Free PMC Article | 01/21/2010 |
| FcgammaRIIB, a low-affinity immunoglobulin G Fc receptor, and CD3 are involved in cerebellar functions. | CD3 and immunoglobulin G Fc receptor regulate cerebellar functions.
Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S., Free PMC Article | 01/21/2010 |
| activation of tumor reactive CD4+ cells with anti-CD3/anti-CD28 monoclonal antibodies | Therapeutic effects of tumor reactive CD4+ cells generated from tumor-primed lymph nodes using anti-CD3/anti-CD28 monoclonal antibodies.
Li Q, Yu B, Grover AC, Zeng X, Chang AE. | 01/21/2010 |