| Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer. | Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer.
Bessoles S, Chiron A, Sarrabayrouse G, De La Grange P, Abina AM, Hacein-Bey-Abina S. | 10/18/2024 |
| CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells. | CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells.
Isaacs JF, Degefu HN, Chen T, Kleist SA, Musial SC, Ford MA, Searles TG, Lin CC, Skorput AGJ, Shirai K, Turk MJ, Zanazzi GJ, Rosato PC., | 09/30/2024 |
| CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection. | CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection.
Araujo Furlan CL, Boccardo S, Rodriguez C, Mary VS, Gimenez CMS, Robson SC, Gruppi A, Montes CL, Acosta Rodríguez EV., Free PMC Article | 06/5/2024 |
| IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells. | IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells.
Chen Y, Zhu M, Hu J, He S, Li S, Liu B, Yang J., Free PMC Article | 05/9/2024 |
| Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation. | Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation.
Aoki T, Wong V, Yin T, Nakamura E, Endo Y, Hayashida K, Robson SC, Nandurkar H, Diamond B, Kim SJ, Murao A, Wang P, Becker LB, Shinozaki K., Free PMC Article | 04/2/2024 |
| NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow. | NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow.
Favre J, Roy C, Guihot AL, Drouin A, Laprise M, Gillis MA, Robson SC, Thorin E, Sévigny J, Henrion D, Kauffenstein G., Free PMC Article | 11/2/2023 |
| Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39. | Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.
Tiwari-Heckler S, Lee GR, Harbison J, Ledderose C, Csizmadia E, Melton D, Zhang Q, Junger W, Chen G, Hauser CJ, Otterbein LE, Longhi MS, Robson SC., Free PMC Article | 01/21/2023 |
| The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39. | The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Xia GQ, Cai JN, Wu X, Fang Q, Zhao N, Lv XW. | 04/16/2022 |
| Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation. | Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.
Smith CJ, Snyder CM., Free PMC Article | 12/25/2021 |
| CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease. | CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Shuai C, Xia GQ, Yuan F, Wang S, Lv XW. | 10/2/2021 |
| CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis. | CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis.
Zhu Y, Zhuang Z, Wu Q, Lin S, Zhao N, Zhang Q, Xie L, Yu S. | 09/18/2021 |
| NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female. | NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.
Babou Kammoe RB, Kauffenstein G, Pelletier J, Robaye B, Sévigny J., Free PMC Article | 07/24/2021 |
| CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/beta-Catenin Pathway in Osteoporosis. | CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/β-Catenin Pathway in Osteoporosis.
Wu W, Xiao Z, Chen Y, Deng Y, Zeng D, Liu Y, Huang F, Wang J, Liu Y, Bellanti JA, Rong L, Zheng SG., Free PMC Article | 06/5/2021 |
| Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection. | Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection.
Peng X, Yong Z, Xiaoyan W, Yuanshan C, Guangzhu W, Xuehuan L. | 05/8/2021 |
| Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP. | Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP.
Cui QQ, Hu ZL, Hu YL, Chen X, Wang J, Mao L, Lu XJ, Ni M, Chen JG, Wang F., Free PMC Article | 05/8/2021 |
| Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. | Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, Lambert S, Weyand CM, Goronzy JJ., Free PMC Article | 02/6/2021 |
| Endogenous antisense RNA curbs CD39 expression in Crohn's disease. | Endogenous antisense RNA curbs CD39 expression in Crohn's disease.
Harshe RP, Xie A, Vuerich M, Frank LA, Gromova B, Zhang H, Robles RJ, Mukherjee S, Csizmadia E, Kokkotou E, Cheifetz AS, Moss AC, Kota SK, Robson SC, Longhi MS., Free PMC Article | 12/5/2020 |
| Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation. | Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation.
Zhao R, Qiao J, Zhang X, Zhao Y, Meng X, Sun D, Peng X., Free PMC Article | 10/24/2020 |
| Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells. | Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells.
Alam MS, Cavanaugh C, Pereira M, Babu U, Williams K. | 10/10/2020 |
| These data indicate the protective role of CD39 in LPSinduced renal tubular epithelial cell damage through inhibiting NLRP3 inflammasome activation and that CD39 might be a potential therapeutic target in sepsisinduced AKI. | Overexpressed CD39 mitigates sepsis‑induced kidney epithelial cell injury via suppressing the activation of NLR family pyrin domain containing 3.
Yang M, Lu L, Kang Z, Ma T, Wang Y., Free PMC Article | 08/1/2020 |
| These data demonstrate that IL-1beta is a key accelerant of venous thrombo-inflammation, which can be suppressed by CD39. CD39 inhibits in vivo crosstalk between inflammation and coagulation pathways, and is a critical vascular checkpoint in venous thrombosis. | Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1β-driven venous thrombosis.
Yadav V, Chi L, Zhao R, Tourdot BE, Yalavarthi S, Jacobs BN, Banka A, Liao H, Koonse S, Anyanwu AC, Visovatti SH, Holinstat MA, Kahlenberg JM, Knight JS, Pinsky DJ, Kanthi Y., Free PMC Article | 05/23/2020 |
| Blockade of the extracellular ATP-P2Y2R signalling represents a potential therapeutic approach against alcoholic liver disease, and CD39 is a potential therapeutic target. | Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation.
Liu ZN, Jia WQ, Jiang T, Dai JW, Shuai C, Lv XW. | 04/25/2020 |
| macrophage expressed CD39 protects from biliary liver injury and fibrosis and support a potential therapeutic target for human hepatobiliary diseases | Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.
Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC., Free PMC Article | 04/11/2020 |
| CD39-null mice developed significantly larger venous thrombi under venous stasis, with more leukocyte recruitment compared with wild-type mice. Gene expression profiling of wild-type and Cd39-null mice revealed 76 differentially expressed inflammatory genes that were significantly upregulated in Cd39-deleted mice after venous thrombosis.These mice manifest an increase in circulating platelet-leukocyte heteroaggregates. | Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39.
Anyanwu AC, Kanthi Y, Fukase K, Liao H, Mimura T, Desch KC, Gruca M, Kaskar S, Sheikh-Aden H, Chi L, Zhao R, Yadav V, Wakefield TW, Hyman MC, Pinsky DJ., Free PMC Article | 01/18/2020 |
| IL-27Ra-deficient Tregs and STAT1-deficient Tregs were less efficient than WT Tregs in suppressing antitumor immunity in vivo. CD39 inhibition significantly abolished IL-27-induced suppressive activities of Tregs. Thus, IL-27 signaling in Tregs critically contributes to protumorigenic properties of Tregs via up-regulation of CD39. | IL-27 confers a protumorigenic activity of regulatory T cells via CD39.
Park YJ, Ryu H, Choi G, Kim BS, Hwang ES, Kim HS, Chung Y., Free PMC Article | 05/4/2019 |