| Proximity-Based Labeling Identifies MHC Class II and CD37 as B Cell Receptor-Proximal Proteins with Immunological Functions. | Proximity-Based Labeling Identifies MHC Class II and CD37 as B Cell Receptor-Proximal Proteins with Immunological Functions.
Hoeger S, Drake LA, Drake JR., Free PMC Article | 04/22/2024 |
| tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration. | C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB. | 10/19/2019 |
| CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway. | Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice.
Rops ALWMM, Jansen E, van der Schaaf A, Pieterse E, Rother N, Hofstra J, Dijkman HBPM, van de Logt AE, Wetzels J, van der Vlag J, van Spriel AB. | 12/22/2018 |
| this study identifies CD37 as a tumor suppressor that directly protects against B cell lymphomagenesis | Tetraspanin CD37 protects against the development of B cell lymphoma.
de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S, van Houdt IS, Gijbels MJ, van de Loo FA, Bennink MB, Hebeda KM, Groenen PJ, van Krieken JH, Figdor CG, van Spriel AB., Free PMC Article | 07/16/2016 |
| The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. | The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
Beckwith KA, Frissora FW, Stefanovski MR, Towns WH, Cheney C, Mo X, Deckert J, Croce CM, Flynn JM, Andritsos LA, Jones JA, Maddocks KJ, Lozanski G, Byrd JC, Muthusamy N., Free PMC Article | 09/13/2014 |
| The cellular defect that underlies poor cellular immune induction in CD37-defcient mice is impaired dendritic cell migration. | Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
Gartlan KH, Wee JL, Demaria MC, Nastovska R, Chang TM, Jones EL, Apostolopoulos V, Pietersz GA, Hickey MJ, van Spriel AB, Wright MD. | 06/22/2013 |
| CD37 was required for the mobility and clustering of alpha(4)beta(1) integrins in the plasma membrane, thus regulating the membrane distribution of alpha(4)beta(1) integrin necessary for activation of the Akt survival pathway | The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.
van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD. | 05/4/2013 |
| CD37 protects against glomerular IgA deposition and renal pathology | The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology.
Rops AL, Figdor CG, van der Schaaf A, Tamboer WP, Bakker MA, Berden JH, Dijkman HB, Steenbergen EJ, van der Vlag J, van Spriel AB., Free PMC Article | 01/1/2011 |
| tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response. | The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG., Free PMC Article | 01/21/2010 |
| CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation | Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC.
Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, Wright MD. | 01/21/2010 |
| The influence of CD37 in the early events of T cell receptor signaling demonstrates a regulatory role for CD37 in T cell proliferation. | A regulatory role for CD37 in T cell proliferation.
van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, Knobeloch KP, Plebanski M, Wright MD. | 01/21/2010 |