| Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals. | Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.
Ghosh S, Ahearn CP, Isabella CR, Marando VM, Dodge GJ, Bartlett H, McPherson RL, Dugan AE, Jain S, Neznanova L, Tettelin H, Putnik R, Grimes CL, Ruhl S, Kiessling LL, Imperiali B., Free PMC Article | 05/31/2023 |
| PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway. | PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway.
Youn SE, Jiang F, Won HY, Hong DE, Kang TH, Park YY, Koh SS., Free PMC Article | 10/22/2022 |
| Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor. | Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.
Yoo W, Choi H, Son YH, Lee J, Jo S, Jung D, Kim YJ, Koh SS, Yang YR, Kwon ES, Lee KP, Noh KH, Kim KW, Ko Y, Jun E, Kim SC, Kim S., Free PMC Article | 03/5/2022 |
| PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/beta-catenin pathway. | PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway.
Escudero-Paniagua B, Bartolomé RA, Rodríguez S, De Los Ríos V, Pintado L, Jaén M, Lafarga M, Fernández-Aceñero MJ, Casal JI. | 09/5/2020 |
| we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells | Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer.
Song J, Lee J, Kim J, Jo S, Kim YJ, Baek JE, Kwon ES, Lee KP, Yang S, Kwon KS, Kim DU, Kang TH, Park YY, Chang S, Cho HJ, Kim SC, Koh SS, Kim S., Free PMC Article | 01/13/2018 |
| Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. | DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer.
Song H, Song J, Kim YJ, Jeong HH, Min HJ, Koh SS. | 11/4/2017 |
| Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma | Pancreatic adenocarcinoma up-regulated factor has oncogenic functions in oral squamous cell carcinoma.
Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H. | 06/24/2017 |
| High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. | Silencing pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer cells to gemcitabine.
Gao CC, Xu XL, Li F, Gong BG, Liu S, Cui YQ, Sun HC, Xu PY, Zheng YM, Jiang H. | 02/18/2017 |
| PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 | Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4.
Kang TH, Kim YS, Kim S, Yang B, Lee JJ, Lee HJ, Lee J, Jung ID, Han HD, Lee SH, Koh SS, Wu TC, Park YM., Free PMC Article | 08/20/2016 |
| constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection | Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling.
Kaowinn S, Cho IR, Moon J, Jun SW, Kim CS, Kang HY, Kim M, Koh SS, Chung YH. | 06/27/2015 |
| PAUF rs12373A>C polymorphisms are associated with colorectal cancer. | Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.
Kim JG, Chae YS, Lee SJ, Kang BW, Park JY, Lee EJ, Jeon HS, Park JS, Choi GS. | 03/21/2015 |
| PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. | Silencing of pancreatic adenocarcinoma upregulated factor by RNA interference inhibits the malignant phenotypes of human colorectal cancer cells.
Liu PF, Wu YY, Hu Y, Wang L, He SB, Zhu YB, Zhu XG. | 01/18/2014 |
| new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases | Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability.
Kim SJ, Lee Y, Kim NY, Hwang Y, Hwang B, Min JK, Koh SS. | 10/19/2013 |
| activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. | SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.
Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH. | 09/22/2012 |
| PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. | PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase.
Lee YS, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS., Free PMC Article | 10/8/2011 |
| PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. | Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of β-catenin, leading to a rapid proliferation of pancreatic cells.
Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston RN, Chung YH., Free PMC Article | 07/23/2011 |
| Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. | Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface.
Ambatipudi KS, Hagen FK, Delahunty CM, Han X, Shafi R, Hryhorenko J, Gregoire S, Marquis RE, Melvin JE, Koo H, Yates JR 3rd., Free PMC Article | 05/28/2011 |
| the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. | Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold.
Kanagawa M, Satoh T, Ikeda A, Nakano Y, Yagi H, Kato K, Kojima-Aikawa K, Yamaguchi Y. | 02/26/2011 |
| PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. | Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation.
Park HD, Lee Y, Oh YK, Jung JG, Park YW, Myung K, Kim KH, Koh SS, Lim DS., Free PMC Article | 02/26/2011 |
| Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. | PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression.
Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB, Kim JM, Lim DS, Koh SS. | 02/8/2010 |
| pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated | Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma.
Kim SA, Lee Y, Jung DE, Park KH, Park JY, Gang J, Jeon SB, Park EC, Kim YG, Lee B, Liu Q, Zeng W, Yeramilli S, Lee S, Koh SS, Song SY., Free PMC Article | 01/21/2010 |
| Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. | Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family.
Mullins JJ, Mullins LJ, Dunbar DR, Brammar WJ, Gross KW, Morley SD. | 01/21/2010 |