| Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice. | Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice.
Michelucci A, Pietrangelo L, Rastelli G, Protasi F, Dirksen RT, Boncompagni S., Free PMC Article | 10/22/2022 |
| Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle. | Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
Jeong SY, Oh MR, Choi JH, Woo JS, Lee EH., Free PMC Article | 12/25/2021 |
| Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. | Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation.
Hanna AD, Lee CS, Babcock L, Wang H, Recio J, Hamilton SL., Free PMC Article | 07/24/2021 |
| Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development. | Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development.
Ambrogini P, Lattanzi D, Di Palma M, Ciacci C, Savelli D, Galati C, Gioacchini AM, Pietrangelo L, Vallorani L, Protasi F, Cuppini R., Free PMC Article | 02/27/2021 |
| Authors hypothesize that the protective effect of aerobic training is essentially mediated by a reduction in oxidative stress during exposure of CASQ1-null mice to adverse environmental conditions. | Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress.
Guarnier FA, Michelucci A, Serano M, Pietrangelo L, Pecorai C, Boncompagni S, Protasi F., Free PMC Article | 10/20/2018 |
| These results suggest that common molecular mechanisms underlie malignant hyperthermia (MH) crises and exertional HS in mice.- | Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
Michelucci A, Paolini C, Boncompagni S, Canato M, Reggiani C, Protasi F., Free PMC Article | 10/14/2017 |
| Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles. | Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles.
Mosca B, Eckhardt J, Bergamelli L, Treves S, Bongianino R, De Negri M, Priori SG, Protasi F, Zorzato F., Free PMC Article | 12/17/2016 |
| Transient knockdown of annexin A6 and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001). | Differential skeletal muscle proteome of high- and low-active mice.
Ferguson DP, Dangott LJ, Schmitt EE, Vellers HL, Lightfoot JT., Free PMC Article | 05/16/2015 |
| Ca(2+) transients evoked by tetanic stimulation are the result of massive Ca(2+) influx due to enhanced Ca(v)1.1 channel activity, which restores muscle strength in JP45/CASQ1 double knockout mice. | Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.
Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F., Free PMC Article | 06/22/2013 |
| Protein levels of CSQ1, SERCA1, and SERCA2 are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs. | Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle.
Kinnunen S, Mänttäri S. | 09/8/2012 |
| results support the view that in skeletal muscles, CASQ1 plays a key role in both Ca(2+) homeostasis and terminal cisternae structure | Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null mice.
Tomasi M, Canato M, Paolini C, Dainese M, Reggiani C, Volpe P, Protasi F, Nori A. | 03/31/2012 |
| The results presented in this paper unmask a differential effect of CASQ1&2 ablation in fast versus slow fibers | Differential effect of calsequestrin ablation on structure and function of fast and slow skeletal muscle fibers.
Paolini C, Quarta M, D'Onofrio L, Reggiani C, Protasi F., Free PMC Article | 01/14/2012 |
| Calsequestrin not only stores Ca(2+), but also varies its affinity in ways that progressively increase the ability of the store to deliver Ca(2+) as it becomes depleted, a novel feedback mechanism of potentially valuable functional implications. | Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle.
Royer L, Sztretye M, Manno C, Pouvreau S, Zhou J, Knollmann BC, Protasi F, Allen PD, Ríos E., Free PMC Article | 01/1/2011 |
| effect of nockdown of CSQ1 in adult mouse skeletal muscle on Store-operated Ca(2+) entry | Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression.
Zhao X, Min CK, Ko JK, Parness J, Kim DH, Weisleder N, Ma J., Free PMC Article | 01/1/2011 |
| ablation of CASQ1 results in malignant hyperthermia- and exertional/environmental heat stroke-like lethal episodes | Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke.
Protasi F, Paolini C, Dainese M., Free PMC Article | 01/21/2010 |
| Data report that calsequestrin-1-null mice exhibit increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death, and show that CASQ1 deficiency alters proper control of ryanodine receptor function. | Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice.
Dainese M, Quarta M, Lyfenko AD, Paolini C, Canato M, Reggiani C, Dirksen RT, Protasi F., Free PMC Article | 01/21/2010 |
| In dystrophin-deficient mdx mice the calsequestrin is overpression in laryngeal muscles. | Sarcoplasmic-endoplasmic-reticulum Ca2+-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficient mdx mice.
Ferretti R, Marques MJ, Pertille A, Santo Neto H. | 01/21/2010 |
| CSQ1 is essential for the normal development of the sarcoplasmic reticulum (SR) and its calcium release units and for the storage and release of appropriate amounts of SR Ca(2+). | Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1.
Paolini C, Quarta M, Nori A, Boncompagni S, Canato M, Volpe P, Allen PD, Reggiani C, Protasi F., Free PMC Article | 01/21/2010 |
| knocking down CSQ2, but not CSQ1, leads to reduced Ca2+ storage and release in C2C12 myotubes | Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes.
Wang Y, Xu L, Duan H, Pasek DA, Eu JP, Meissner G. | 01/21/2010 |