| Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity. | Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity.
Li J, Han X, Sun M, Li W, Yang G, Chen H, Guo B, Li J, Li X, Wang H., Free PMC Article | 12/18/2023 |
| Caspase-9 driven murine model of selective cell apoptosis and efferocytosis. | Caspase-9 driven murine model of selective cell apoptosis and efferocytosis.
Batoon L, Koh AJ, Kannan R, McCauley LK, Roca H., Free PMC Article | 02/4/2023 |
| Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline. | Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline.
Colón Ortiz C, Neal AM, Avrutsky MI, Choi M, Smart J, Lawson J, Troy CM., Free PMC Article | 11/19/2022 |
| Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects. | Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects.
Bowen ME, Mulligan AS, Sorayya A, Attardi LD., Free PMC Article | 03/5/2022 |
| Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration. | Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
Ankawa R, Goldberger N, Yosefzon Y, Koren E, Yusupova M, Rosner D, Feldman A, Baror-Sebban S, Buganim Y, Simon DJ, Tessier-Lavigne M, Fuchs Y. | 10/23/2021 |
| BICAO-induced ischaemia caused depressive-like behaviours and caspase-8/-9-dependent brain regional neural cell apoptosis in mice. | BICAO-induced ischaemia caused depressive-like behaviours and caspase-8/-9-dependent brain regional neural cell apoptosis in mice.
Liu S, Han S, Dai Q, Li S, Li J., Free PMC Article | 02/2/2021 |
| Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development. | Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development.
Liu X, Castle V, Taketo T., Free PMC Article | 09/12/2020 |
| Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. | Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM., Free PMC Article | 08/29/2020 |
| Apoptosis induced by ESAT-6 was mainly via the intrinsic pathway with elevated protein levels of cleaved caspase-9 and -3. Furthermore, ESAT-6 also induced Bim activation during this process. | Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages.
Lin J, Chang Q, Dai X, Liu D, Jiang Y, Dai Y. | 07/20/2019 |
| Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy. | Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.
Guo R, Lin B, Pan JF, Liong EC, Xu AM, Youdim M, Fung ML, So KF, Tipoe GL., Free PMC Article | 05/19/2018 |
| inducible caspase-9 (iC9) safety switch can eliminate CD19.CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19.CAR-T expansion in case of CRS or complete deletion on demand granting normal B cell reconstitution. | Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells.
Diaconu I, Ballard B, Zhang M, Chen Y, West J, Dotti G, Savoldo B., Free PMC Article | 06/10/2017 |
| Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3/7, in a dose-dependent fashion. | Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells.
Uto T, Toyama M, Yoshinaga K, Baba M. | 03/25/2017 |
| Bcl-2-caspase-9 apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins. | Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice.
Xu W, Guo G, Li J, Ding Z, Sheng J, Li J, Tan W., Free PMC Article | 07/30/2016 |
| Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. | An epistatic effect of apaf-1 and caspase-9 on chlamydial infection.
Rahman MA, Shirai M, Aziz MA, Ushirokita R, Kubota S, Suzuki H, Azuma Y., Free PMC Article | 06/28/2016 |
| The study demonstrates sublethal caspase-activation has an important role in cardiomyocyte differentiation and may have significant implications for promoting cardiac regeneration after myocardial injury involving exogenous or endogenous cell sources. | Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells.
Bulatovic I, Ibarra C, Österholm C, Wang H, Beltrán-Rodríguez A, Varas-Godoy M, Månsson-Broberg A, Uhlén P, Simon A, Grinnemo KH., Free PMC Article | 05/7/2016 |
| Casp6 knockout in YAC128 mice does not abolish the presence of the mutant HTT protein-586 fragment but ameliorates depression, body weight gain, IGF-1 and BDNF levels in YAC128 mice. | Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
Wong BKY, Ehrnhoefer DE, Graham RK, Martin DDO, Ladha S, Uribe V, Stanek LM, Franciosi S, Qiu X, Deng Y, Kovalik V, Zhang W, Pouladi MA, Shihabuddin LS, Hayden MR. | 12/19/2015 |
| study demonstrates that MMP-3 leads to caspase-9 activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1 | Caspase-9 activation and Apaf-1 cleavage by MMP-3.
Kim EM, Shin EJ, Lee JA, Son HJ, Choi DH, Han JM, Hwang O. | 07/25/2015 |
| caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. | Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.
Nie C, Luo Y, Zhao X, Luo N, Tong A, Liu X, Yuan Z, Wang C, Wei Y., Free PMC Article | 06/20/2015 |
| Casp9, the initiator caspase of the intrinsic apoptotic cascade, has a role in murine fetal and adult hematopoiesis | Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA., Free PMC Article | 02/28/2015 |
| Effect of cortisol on caspases in the co-cultured C2C12 and 3 T3-L1 cells. | Effect of cortisol on caspases in the co-cultured C2C12 and 3 T3-L1 cells.
Muthuraman P. | 02/14/2015 |
| findings demonstrate that focal activation of caspase-9 and -3 at neuromuscular junctions is essentially responsible for subsynaptic DNA damage and apoptotic synaptic degeneration in slow-channel myasthenic syndrome | Selective inhibition of caspases in skeletal muscle reverses the apoptotic synaptic degeneration in slow-channel myasthenic syndrome.
Zhu H, Pytel P, Gomez CM. | 08/9/2014 |
| The activity of caspase-3, -8 and -9 was significantly increased in the isoflurane-treated cells compared with the untreated cells. | Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway.
Bai T, Dong DS, Pei L. | 03/29/2014 |
| After activation by caspase-9, caspase-3 inhibits ROS production and is required for efficient execution of apoptosis, while effector caspase-7 is required for apoptotic cell detachment. | Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH., Free PMC Article | 11/30/2013 |
| The mitochondrial apoptotic pathway mediated by caspase 9 is constitutively activated in oocytes. | Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression.
Ene AC, Park S, Edelmann W, Taketo T., Free PMC Article | 06/15/2013 |
| DP T cell apoptosis following experimental T. cruzi acute infection is dependent on glucocorticoid stimulation, promoting caspase-8 and -9 activation | Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice.
Farias-de-Oliveira DA, Villa-Verde DM, Nunes Panzenhagen PH, Silva dos Santos D, Berbert LR, Savino W, de Meis J. | 04/6/2013 |