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    Casp4 caspase 4, apoptosis-related cysteine peptidase [ Mus musculus (house mouse) ]

    Gene ID: 12363, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.

    Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.
    Wan Y, Li J, Pu J, Yang J, Pei C, Qi Y., Free PMC Article

    10/7/2024
    TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.

    TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.
    Bai D, Zhou C, Du J, Zhao J, Gu C, Wang Y, Zhang L, Lu N, Zhao Y., Free PMC Article

    10/2/2024
    Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation.

    Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation.
    Veselá B, Bzdúšková J, Ramešová A, Švandová E, Grässel S, Matalová E.

    09/3/2024
    Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection.

    Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection.
    Liang N, Li Y, Yuan C, Zhong X, Yang Y, Liang F, Zhao K, Yuan F, Shi J, Wang E, Zhong Y, Tian G, Lu B, Tang Y., Free PMC Article

    08/26/2024
    Casp11 Deficiency Alters Subgingival Microbiota and Attenuates Periodontitis.

    Casp11 Deficiency Alters Subgingival Microbiota and Attenuates Periodontitis.
    Fu SL, Qian YY, Dai AN, Li HY, Jin XH, He WT, Kang S, Ding PH.

    05/24/2024
    Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.

    Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
    Román-Domínguez L, Salazar-León J, Meza-Sosa KF, Pérez-Martínez L, Pedraza-Alva G., Free PMC Article

    05/1/2024
    Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.

    Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.
    Liang W, Wei R, Zhu X, Li J, Lin A, Chen J, Wu W, Jie Q., Free PMC Article

    03/18/2024
    Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.

    Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
    Cai R, Gong X, Li X, Jiang Y, Deng S, Tang J, Ge H, Wu C, Tang H, Wang G, Xie L, Chen X, Hu X, Feng J., Free PMC Article

    03/13/2024
    DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease.

    DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
    Daily KP, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan MH, Carafice C, Krause K, McNamara A, Hamilton K, Houle S, Gupta S, Gupta GA, Madhu S, Fitzgerald J, Saadey AA, Laster B, Yan P, Webb A, Zhang X, Pietrzak M, Kokiko-Cochran ON, Ghoneim HE, Amer AO., Free PMC Article

    02/21/2024
    Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.

    Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.
    Akuma DC, Wodzanowski KA, Schwartz Wertman R, Exconde PM, Vázquez Marrero VR, Odunze CE, Grubaugh D, Shin S, Taabazuing C, Brodsky IE., Free PMC Article

    02/6/2024
    LincRNA-EPS inhibits caspase-11 and NLRP3 inflammasomes in gingival fibroblasts to alleviate periodontal inflammation.

    LincRNA-EPS inhibits caspase-11 and NLRP3 inflammasomes in gingival fibroblasts to alleviate periodontal inflammation.
    Hu A, Xiao F, Wu W, Xu H, Su J., Free PMC Article

    01/9/2024
    Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice.

    Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice.
    Karasawa T, Komada T, Baatarjav C, Aizawa E, Mizushina Y, Fujimura K, Gunji Y, Komori S, Aizawa H, Jing Tao CB, Matsumura T, Takahashi M.

    11/28/2023
    High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.

    High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.
    Thomas SM, Olive AJ., Free PMC Article

    09/7/2023
    Ghrelin protects against ischemia/reperfusion-induced hepatic injury via inhibiting Caspase-11-mediated noncanonical pyroptosis.

    Ghrelin protects against ischemia/reperfusion-induced hepatic injury via inhibiting Caspase-11-mediated noncanonical pyroptosis.
    Tong L, Liu R, Yang Y, Zhao J, Ye S, Wang X, Qin Y.

    08/14/2023
    Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1beta-converting enzyme.

    Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
    Chan AH, Burgener SS, Vezyrgiannis K, Wang X, Acklam J, Von Pein JB, Pizzuto M, Labzin LI, Boucher D, Schroder K., Free PMC Article

    08/11/2023
    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.

    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.
    Ma Y, Zhao R, Guo H, Tong Q, Langdon WY, Liu W, Zhang J, Zhang J., Free PMC Article

    08/3/2023
    CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.

    CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
    Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, Lopes LS, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS.

    06/16/2023
    Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

    Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.
    Drummer C 4th, Saaoud F, Jhala NC, Cueto R, Sun Y, Xu K, Shao Y, Lu Y, Shen H, Yang L, Zhou Y, Yu J, Wu S, Snyder NW, Hu W, Zhuo J', Zhong Y, Jiang X, Wang H, Yang X., Free PMC Article

    02/15/2023
    Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.

    Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.
    Cheng Y, Manabe I, Hayakawa S, Endo Y, Oishi Y., Free PMC Article

    02/15/2023
    Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.

    Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
    Fernández-Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar FR, Lagnado AB, Smer-Barreto V, Muir M, Brunton VG, Passos JF, Acosta JC., Free PMC Article

    06/18/2022
    Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.

    Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
    Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO., Free PMC Article

    05/28/2022
    Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.

    Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
    Yuan C, Wu M, Xiao Q, Zhao W, Li H, Zhong Y, Zhao M, Li C, Li Y, Yang X., Free PMC Article

    03/26/2022
    Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease.

    Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease.
    Yin F, Zheng PQ, Zhao LQ, Wang YZ, Miao NJ, Zhou ZL, Cheng Q, Chen PP, Xie HY, Li JY, Ni JY, Zhou L, Zhang W, Wang XX, Liu J, Lu LM., Free PMC Article

    03/19/2022
    Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury.

    Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury.
    Sun W, Lu H, Dong S, Li R, Chu Y, Wang N, Zhao Y, Zhang Y, Wang L, Sun L, Lu D., Free PMC Article

    02/26/2022
    Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense.

    Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense.
    Kumari P, Russo AJ, Wright SS, Muthupalani S, Rathinam VA., Free PMC Article

    02/19/2022
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