| Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest. | Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest.
Velayutham N, Calderon MU, Alfieri CM, Padula SL, van Leeuwen FN, Scheijen B, Yutzey KE., Free PMC Article | 05/17/2023 |
| BTG1 mutation yields supercompetitive B cells primed for malignant transformation. | BTG1 mutation yields supercompetitive B cells primed for malignant transformation.
Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A., Free PMC Article | 02/22/2023 |
| Obesity-induced upregulation of microRNA-183-5p promotes hepatic triglyceride accumulation by targeting the B-cell translocation gene 1. | Obesity-induced upregulation of microRNA-183-5p promotes hepatic triglyceride accumulation by targeting the B-cell translocation gene 1.
Zhou X, Yuan Y, Teng F, Li K, Luo S, Zhang P, Liu D, Zhang H, Zhang J. | 03/6/2021 |
| that DGCR5 is a tumor-suppressive lncRNA that regulates PTEN and BTG1 expression through directly binding to miR-23b | Long noncoding RNA DGCR5 suppresses gastric cancer progression by acting as a competing endogenous RNA of PTEN and BTG1.
Xu Y, Zhang G, Zou C, Gong Z, Wang S, Liu J, Ma G, Liu X, Zhang W, Jiang P. | 05/16/2020 |
| BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. | mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.
Hwang SS, Lim J, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li HB, Flavell RA. | 04/11/2020 |
| Together these results identify BCL6 as a potential driver of ETV6-RUNX1-mediated leukemogenesis, which could involve loss of BTG1-dependent suppression of ETV6-RUNX1 function. | Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1.
Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Gerritsen M, van der Meer LT, Williams O, Hoogerbrugge PM, Scheijen B, van Leeuwen FN. | 11/10/2018 |
| Subventricular zone stem cells are endowed with a hidden supply of self-renewal capacity, coupled to cell cycle acceleration and emerging after ablation of the quiescence-maintaining Btg1 gene and following exercise. | Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice.
Mastrorilli V, Scopa C, Saraulli D, Costanzi M, Scardigli R, Rouault JP, Farioli-Vecchioli S, Tirone F. | 02/3/2018 |
| Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development. | Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development.
Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Havinga J, Rouault JP, Hoogerbrugge PM, van Leeuwen FN, Scheijen B., Free PMC Article | 01/27/2018 |
| BTG1 has a role in regulating hepatic lipid metabolism and in preventing ATF4 and SCD1 from inducing liver steatosis | BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism.
Xiao F, Deng J, Guo Y, Niu Y, Yuan F, Yu J, Chen S, Guo F. | 12/2/2017 |
| our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function. | Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN., Free PMC Article | 07/8/2017 |
| the findings provide evidence for a role of Btg1 regulating the initial differentiation of cartilage and tendons. | The tumor suppressor BTG1 is expressed in the developing digits and regulates skeletogenic differentiation of limb mesodermal progenitors in high density cultures.
Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM, Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM. | 03/18/2017 |
| BTG1 overexpression or knockdown improved or impaired insulin signaling respectively. | A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun.
Xiao F, Deng J, Yu J, Guo Y, Chen S, Guo F. | 06/11/2016 |
| Btg1 regulates the proliferation of cerebellar granule precursors selectively through cyclin D1. | Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1.
Ceccarelli M, Micheli L, D'Andrea G, De Bardi M, Scheijen B, Ciotti M, Leonardi L, Luvisetto S, Tirone F. | 05/28/2016 |
| these data show that both Btg1 and Btg2 are required for normal vertebral patterning of the axial skeleton, but each gene contributes differently in specifying the identity along the anterior-posterior axis of the skeleton. | Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.
Tijchon E, van Ingen Schenau D, van Opzeeland F, Tirone F, Hoogerbrugge PM, Van Leeuwen FN, Scheijen B., Free PMC Article | 04/30/2016 |
| Btg1 gain- and loss-of-function experiments were consistent with the pattern of expression of this gene in the developing digits. We detected a negative influence of BTG1 in the progress of cartilage maturation and a positive influence in the formation of fibrogenic tissue. | The tumor suppressor BTG1 is expressed in the developing digits and regulates skeletogenic differentiation of limb mesodermal progenitors in high density cultures.
Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM, Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM. | 12/16/2015 |
| Antiproliferative BTG1 may participate in the activation-induced cell death of microglia by lowering the threshold for apoptosis. | Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia.
Lee H, Cha S, Lee MS, Cho GJ, Choi WS, Suk K. | 01/21/2010 |