| ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice. | ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.
Bathula CS, Chen J, Kumar R, Blackshear PJ, Saini Y, Patial S., Free PMC Article | 03/5/2022 |
| Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1. | Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Saveliev A, Bell SE, Turner M., Free PMC Article | 09/18/2021 |
| Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. | Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.
Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ., Free PMC Article | 10/3/2020 |
| Study shows that the ZFP36 family member, ZFP36L1, is specifically upregulated in osteoarthritis (OA) chondrocytes and OA cartilage of humans and mice. ZFP36L1 regulates the mRNAs encoding two members of the HSP70 family that appear to exert protective effects on OA pathogenesis by inhibiting chondrocyte apoptosis. | RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.
Son YO, Kim HE, Choi WS, Chun CH, Chun JS., Free PMC Article | 02/23/2019 |
| ZFP36L1 protein is expressed in satellite cells. ZFP36L1 and ZFP36L2 act redundantly in myogenesis. | The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.
Bye-A-Jee H, Pugazhendhi D, Woodhouse S, Brien P, Watson R, Turner M, Pell J., Free PMC Article | 02/16/2019 |
| the ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis. | RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.
Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ., Free PMC Article | 10/21/2017 |
| The Zfp36l1 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control. | The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.
Vogel KU, Bell LS, Galloway A, Ahlfors H, Turner M., Free PMC Article | 10/7/2017 |
| Our data indicated that ZFP36L1 could act as an enhancer of osteoblastic differentiation but a repressor of adipogenic differentiation, supporting the notion that decreased ZFP36L1 expression in bone marrow stem cells might contribute to aging-related bone loss. | Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells.
Tseng KY, Chen YH, Lin S., Free PMC Article | 09/30/2017 |
| ZFP36L1 is the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 and IRF8, which are known to enforce e follicular B cell phenotype. | Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M., Free PMC Article | 08/19/2017 |
| ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle. | RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M. | 05/14/2016 |
| Myeloid ZFP36 may fully compensate for loss of ZFP36L1. | Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection.
Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR., Free PMC Article | 06/20/2015 |
| ZFP36L1 interacts with and mediates degradation of anti-apoptotic BCL2 mRNA as its important target in malignant B-cells. | Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.
Zekavati A, Nasir A, Alcaraz A, Aldrovandi M, Marsh P, Norton JD, Murphy JJ., Free PMC Article | 03/7/2015 |
| Challenging the renal osmotic gradient by submitting mice to water deprivation, diuretic administration, or high-Na(+) diet increased renal Tis11b and decreased mineralocorticoid receptor expression, particularly in the cortex. | Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.
Viengchareun S, Lema I, Lamribet K, Keo V, Blanchard A, Cherradi N, Lombès M., Free PMC Article | 12/20/2014 |
| Findings suggest that ZFP36L1 negatively regulates plasmacytoid differentiation, at least in part, by targeting the expression of BLIMP1. | ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA.
Nasir A, Norton JD, Baou M, Zekavati A, Bijlmakers MJ, Thompson S, Murphy JJ., Free PMC Article | 06/22/2013 |
| Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity. | Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
Lin NY, Lin TY, Yang WH, Wang SC, Wang KT, Su YL, Jiang YW, Chang GD, Chang CJ., Free PMC Article | 10/20/2012 |
| I postulate that the embryonic arrest linked to the DeltaN-Zfp36l2 truncation might be related to its resistance to stimulus-induced down-regulation. | Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility.
Ramos SB., Free PMC Article | 06/23/2012 |
| ZFP36L1 has a critical role in lymphocyte development and may function as a tumor suppressor. | Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.
Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M., Free PMC Article | 08/30/2010 |
| Results suggest that TIS11b suppression of 3.5-kb mRNA is coupled to enhanced steroidogenic acute regulatory protein translation leading to increased cholesterol metabolism. | cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b.
Duan H, Cherradi N, Feige JJ, Jefcoate C., Free PMC Article | 01/21/2010 |
| Since specific inhibitors of p38 MAP kinase completely blocked Tis11B induction, we conclude that expression of the Tis11B gene is regulated at least in part by this signaling pathway which plays a central role in myogenesis. | Strong induction of the Tis11B gene in myogenic differentiation.
Busse M, Schwarzburger M, Berger F, Hacker C, Munz B. | 01/21/2010 |
| Results suggest that lack of Zfp36L1 expression during mid-gestation results in the abnormal stabilization of one or more mRNAs whose encoded proteins lead directly or indirectly to abnormal placentation and fetal death. | Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.
Stumpo DJ, Byrd NA, Phillips RS, Ghosh S, Maronpot RR, Castranio T, Meyers EN, Mishina Y, Blackshear PJ., Free PMC Article | 01/21/2010 |
| Knocking down TIS11b expression in primary adrenocortical cells with small interfering (si)RNAs clearly indicated that TIS11b participates in the control of both basal and, to a larger extent, ACTH-induced VEGF mRNA expression levels | Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.
Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, Lamarre J, Feige JJ. | 01/21/2010 |
| These data implicate Zfp36l1as a negative regulator of Vegf-a gene activity during development. | The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression.
Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, Burton GJ, Murphy JJ, Norton JD, Clark AR, Turner M. | 01/21/2010 |
| Data suggest an important role for butyrate response factor-1 in osteoblasts within the molecular network of parathyroid hormone-dependent bone remodeling. | Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.
Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R. | 01/21/2010 |