| Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling. | Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling.
Yang D, Pei G, Dong S, Zhang W, Deng H, Zhao X, Li P, Lin X. | 03/10/2023 |
| Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. | Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.
Wang B, Jiang B, Li GW, Dong F, Luo Z, Cai B, Wei M, Huang J, Wang K, Feng X, Tong F, Wang S, Wang Q, Han Q, Li C, Zhang X, Yang L, Bao L., Free PMC Article | 02/15/2023 |
| USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10. | USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10.
Fu Y, Wang P, Zhao J, Tan Y, Sheng J, He S, Du X, Huang Y, Yang Y, Li J, Cai Y, Liu Y, Hu S., Free PMC Article | 03/26/2022 |
| Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation. | Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation.
Kurgyis Z, Vornholz L, Pechloff K, Kemény LV, Wartewig T, Muschaweckh A, Joshi A, Kranen K, Hartjes L, Möckel S, Steiger K, Hameister E, Volz T, Mellett M, French LE, Biedermann T, Korn T, Ruland J. | 03/12/2022 |
| Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10. | Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10.
Campanello L, Traver MK, Shroff H, Schaefer BC, Losert W., Free PMC Article | 09/11/2021 |
| Bcl10 is associated with actin dynamics at the T cell immune synapse. | Bcl10 is associated with actin dynamics at the T cell immune synapse.
Wagh K, Wheatley BA, Traver MK, Hussain I, Schaefer BC, Upadhyaya A., Free PMC Article | 03/13/2021 |
| B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury. | B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury.
Markó L, Park JK, Henke N, Rong S, Balogh A, Klamer S, Bartolomaeus H, Wilck N, Ruland J, Forslund SK, Luft FC, Dechend R, Müller DN. | 10/24/2020 |
| results demonstrate that partial disruption of the CBM complex and induction of IFNgamma secretion in the preferentially self-reactive Treg cell pool does not cause systemic autoimmunity but is sufficient to prime the tumour environment for successful immune checkpoint therapy | Targeting the CBM complex causes T(reg) cells to prime tumours for immune checkpoint therapy.
Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR., Free PMC Article | 09/21/2019 |
| CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-kappaB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can bypass the CBM requirement for this differentiation step. | Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, Hartjes L, Krebs S, Krappmann D, Kriegsmann M, Weichert W, Rad R, Kurts C, Ruland J., Free PMC Article | 06/22/2019 |
| IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. | Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.
Karim ZA, Hensch NR, Qasim H, Alshbool FZ, Khasawneh FT., Free PMC Article | 09/22/2018 |
| high fat diet (HFD) and zinc deficiency synergistically induce obesity-related cardiac hypertrophy (ORCH), by increasing oxidative stress-mediated activation of BCL10/CARD9/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress-activated BCL10 expression and p38 MAPK activation. | Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10/CARD9/p38 MAPK pathway.
Wang S, Gu J, Xu Z, Zhang Z, Bai T, Xu J, Cai J, Barnes G, Liu QJ, Freedman JH, Wang Y, Liu Q, Zheng Y, Cai L., Free PMC Article | 02/24/2018 |
| Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity. | Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
Torres JM, Martinez-Barricarte R, García-Gómez S, Mazariegos MS, Itan Y, Boisson B, Rholvarez R, Jiménez-Reinoso A, del Pino L, Rodríguez-Pena R, Ferreira A, Hernández-Jiménez E, Toledano V, Cubillos-Zapata C, Díaz-Almirón M, López-Collazo E, Unzueta-Roch JL, Sánchez-Ramón S, Regueiro JR, López-Granados E, Casanova JL, Pérez de Diego R., Free PMC Article | 07/25/2015 |
| cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. | T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
Hamilton KS, Phong B, Corey C, Cheng J, Gorentla B, Zhong X, Shiva S, Kane LP., Free PMC Article | 02/14/2015 |
| Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex. | C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.
Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Luo T, Jia XM, Lin X., Free PMC Article | 02/14/2015 |
| Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling. | Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.
Markó L, Henke N, Park JK, Spallek B, Qadri F, Balogh A, Apel IJ, Oravecz-Wilson KI, Choi M, Przybyl L, Binger KJ, Haase N, Wilck N, Heuser A, Fokuhl V, Ruland J, Lucas PC, McAllister-Lucas LM, Luft FC, Dechend R, Müller DN., Free PMC Article | 01/17/2015 |
| TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement. | T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.
Paul S, Traver MK, Kashyap AK, Washington MA, Latoche JR, Schaefer BC., Free PMC Article | 01/3/2015 |
| Bcl10 is an essential regulator for A20 gene expression. | Bcl10 is an essential regulator for A20 gene expression.
Xu W, Xue L, Sun Y, Henry A, Battle JM, Micault M, Morris SW. | 07/19/2014 |
| Data indicate that caspase recruitment domain-containing protein 11 (CARD11) is involved in the pathogenesis of collagen-induced arthritis (CIA) by formation of the CARD11/Bcl10 complex and enhancement of the Th17 cell response. | CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response.
Wang H, Zhao J, Zhang H, Huang Y, Wang S, Tu Q, Yang N., Free PMC Article | 06/21/2014 |
| Findings demonstrate a Bcl10 requirement for maximum development of carrageenan-induced inflammation and lack of complete suppression by IL-10 of carrageenan-induced inflammation. | Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Bhattacharyya S, Xue L, Devkota S, Chang E, Morris S, Tobacman JK., Free PMC Article | 12/7/2013 |
| Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance. | Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance.
Van Beek M, Oravecz-Wilson KI, Delekta PC, Gu S, Li X, Jin X, Apel IJ, Konkle KS, Feng Y, Teitelbaum DH, Ruland J, McAllister-Lucas LM, Lucas PC., Free PMC Article | 04/20/2013 |
| identify Bcl10 as an early coordinator of NF-kappaB-mediated immune response with endosomal trafficking and signaling to F-actin remodeling | The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.
Marion S, Mazzolini J, Herit F, Bourdoncle P, Kambou-Pene N, Hailfinger S, Sachse M, Ruland J, Benmerah A, Echard A, Thome M, Niedergang F. | 02/2/2013 |
| Bcl10 controls BAFF-induced canonical NF-kB activation directly and noncanonical NF-kB activation indirectly determining the survival of anergic B cells. | Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Yu M, Chen Y, He Y, Podd A, Fu G, Wright JA, Kleiman E, Khan WN, Wen R, Wang D., Free PMC Article | 01/26/2013 |
| These studies provide molecular insight into the assembly of CARMA1 and BCL10. | Structural insights into the assembly of CARMA1 and BCL10.
Li S, Yang X, Shao J, Shen Y., Free PMC Article | 01/12/2013 |
| TCR engagement triggers the degradation of Bcl10 in primary effector T cells but not in naive T cells. It promoted K63 polyubiquitination of Bcl10, causing Bcl10 association with the autophagy adaptor p62. | Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
Paul S, Kashyap AK, Jia W, He YW, Schaefer BC., Free PMC Article | 09/15/2012 |
| Our data demonstrate a novel effect of overexpressed BCL10 in the pathogenesis of high-grade MALT lymphoma by increasing expression of API2 and it then forming a protein complex with BCL10/caspase-8 leading to caspase-8 activity suppression. | Inhibition of caspase-8 activity caused by overexpression of BCL10 contributes to the pathogenesis of high-grade MALT lymphoma.
Chen Y, Yang Y, Sun M, Yan Z, Wu L, Cui X, Zhang G, Morris SW, Zhang Q. | 05/19/2012 |