| Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. | Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
Mao Y, Shi D, Li G, Jiang P. | 03/5/2022 |
| Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis. | Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.
van der Meer JHM, de Boer RJ, Meijer BJ, Smit WL, Vermeulen JLM, Meisner S, van Roest M, Koelink PJ, Dekker E, Hakvoort TBM, Koster J, Hawinkels LJAC, Heijmans J, Struijs EA, Boermeester MA, van den Brink GR, Muncan V., Free PMC Article | 02/5/2022 |
| findings uncover a new function of p53 in the regulation of Akt signaling and reveal how p53, ASS1, and Akt are interrelated to each other. | Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53.
Miyamoto T, Lo PHY, Saichi N, Ueda K, Hirata M, Tanikawa C, Matsuda K., Free PMC Article | 10/13/2018 |
| ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1, leading to the circadian regulation of ASS1 and ureagenesis. | CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.
Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. | 10/21/2017 |
| In diabetic mice, ablation of Ass resulted in diminished endothelium-derived nitric oxide-mediated vascular relaxation responses. | Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice.
Chennupati R, Meens MJ, Marion V, Janssen BJ, Lamers WH, De Mey JG, Köhler SE., Free PMC Article | 12/26/2015 |
| cAMP-induced Ass1 expression is important in controlling the magnitude of decidualization through regulating L-Arg level. | Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization.
Huang Z, Wang TS, Zhao YC, Zuo RJ, Deng WB, Chi YJ, Yang ZM. | 12/20/2014 |
| may contribute to liver injury by enhancing nitrosative stress | Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase.
Lu Y, Ward SC, Nieto N., Free PMC Article | 11/22/2014 |
| We demonstrate that the transgenic mouse system reported here has the merit of sensitivity and direct visualization advantage, and is ideal for annotating temporal and spatial expression profiles and the regulation mode of the ASS gene. | A transgenic approach to study argininosuccinate synthetase gene expression.
Shiue SC, Huang MZ, Su TS., Free PMC Article | 09/13/2014 |
| Thus, extracellular arginine fuels rapid NO production in activated macrophages, and citrulline recycling via Ass1 and Asl is a fail-safe system that sustains optimum NO production. | Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.
Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, Decker T, Miyairi I, Vogel SN, Salgame P, Rock CO, Murray PJ., Free PMC Article | 02/2/2013 |
| Partial argininosuccinate synthase ablation protects only in acute ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario where oxidative stress and impaired fatty acid beta-oxidation are key events. | Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice.
Leung TM, Lu Y, Yan W, Morón-Concepción JA, Ward SC, Ge X, Conde de la Rosa L, Nieto N., Free PMC Article | 06/23/2012 |
| Loss of Ass1 is associated with citrullinemia type I and other hyperammonemic syndromes. | Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
Perez CJ, Jaubert J, Guénet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F., Free PMC Article | 03/12/2011 |
| Argininosuccinate synthetase has a role in preventing autotoxicity from nitric oxide overproduction | Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.
Hao G, Xie L, Gross SS. | 01/21/2010 |