| Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex. | Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Hall ET, Dillard ME, Stewart DP, Zhang Y, Wagner B, Levine RM, Pruett-Miller SM, Sykes A, Temirov J, Cheney RE, Mori M, Robinson CG, Ogden SK., Free PMC Article | 01/29/2022 |
| The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. | The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Echevarría-Andino ML, Allen BL., Free PMC Article | 02/2/2021 |
| Boc acts as a Shh-dependent endocytic platform gating Ptch1 internalization and Shh signaling in growth-cone turning and axon guidance. | Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance.
Ferent J, Giguère F, Jolicoeur C, Morin S, Michaud JF, Makihara S, Yam PT, Cayouette M, Charron F. | 03/28/2020 |
| Findings provide evidence for a dual requirement for Boc and Gas1 during early development of the palate, mediating cell cycle regulation during growth and subsequent fusion of the palatal shelves. | Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis.
Xavier GM, Seppala M, Papageorgiou SN, Fan CM, Cobourne MT., Free PMC Article | 02/17/2018 |
| BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth. | A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
Vuong TA, Leem YE, Kim BG, Cho H, Lee SJ, Bae GU, Kang JS. | 12/2/2017 |
| Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc | Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc.
Lee HJ, Jo SB, Romer AI, Lim HJ, Kim MJ, Koo SH, Krauss RS, Kang JS., Free PMC Article | 08/22/2015 |
| Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma. | The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.
Mille F, Tamayo-Orrego L, Lévesque M, Remke M, Korshunov A, Cardin J, Bouchard N, Izzi L, Kool M, Northcott PA, Taylor MD, Pfister SM, Charron F. | 01/10/2015 |
| The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent of the retina is required to sustain Zic2 expression, likely by regulating the levels of Shh signaling from the nearby cRGCs. Zic2. | Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.
Sánchez-Arrones L, Nieto-Lopez F, Sánchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P., Free PMC Article | 08/3/2013 |
| Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly. | Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.
Zhang W, Hong M, Bae GU, Kang JS, Krauss RS., Free PMC Article | 09/3/2011 |
| Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation. | Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.
Izzi L, Lévesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F., Free PMC Article | 08/20/2011 |
| Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ., Free PMC Article | 09/27/2010 |
| Boc expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice. | Differential screening identifies transcripts with depot-dependent expression in white adipose tissues.
Wu Y, Kim JY, Zhou S, Smas CM., Free PMC Article | 01/21/2010 |
| data suggest that Boc is essential as a receptor for Shh in commissural axon guidance | Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK. | 01/21/2010 |
| Expression of the boc gene during murine embryogenesis | Expression of the boc gene during murine embryogenesis.
Mulieri PJ, Kang JS, Sassoon DA, Krauss RS. | 01/21/2010 |
| Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. | The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. | 01/21/2010 |