| Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis. | Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis.
Özcan Ö, Akyol Ö, Akyol A., Free PMC Article | 08/27/2024 |
| Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction. | Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction.
Zhong C, Que D, Yu W, Chen D, Wang Y, Zhang X, Rui B, Yang Y, Hong Q, Huang G, Yang L, Yan J, Yang P. | 05/24/2023 |
| Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity. | Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
Jargaud V, Bour S, Tercé F, Collet X, Valet P, Bouloumié A, Guillemot JC, Mauriège P, Jalkanen S, Stolen C, Salmi M, Smith DJ, Carpéné C. | 08/7/2021 |
| Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1. | Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1.
Kubota R, Reid MJ, Lieu KL, Orme M, Diamond C, Tulberg N, Henry SH., Free PMC Article | 07/10/2021 |
| The results establish a role for Copper homeostasis in adipocyte metabolism and identify SSAO as a regulator of energy utilization processes in adipocytes. | Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes.
Yang H, Ralle M, Wolfgang MJ, Dhawan N, Burkhead JL, Rodriguez S, Kaplan JH, Wong GW, Haughey N, Lutsenko S., Free PMC Article | 04/27/2019 |
| The blockade of VAP-1 could be a promising medical modality to combat the acute and chronic variants. | Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice.
Mukai S, Ogawa Y, Kawakami Y, Mashima Y, Tsubota K. | 02/16/2019 |
| Data indicate strong-to-moderate expression of vascular adhesion protein-1 (VAP-1) in the synovium of Borrelia burgdorferi-infected mice, while only weak expression of VAP-1 was detected in uninfected mice. | Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.
Siitonen R, Pietikäinen A, Liljenbäck H, Käkelä M, Söderström M, Jalkanen S, Hytönen J, Roivainen A., Free PMC Article | 07/14/2018 |
| VAP-1 was expressed on endothelial cells lining inflamed atherosclerotic lesions; normal vessel walls in aortas of C57BL/6N control mice were VAP-1-negative. | Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.
Silvola JM, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A., Free PMC Article | 04/28/2018 |
| VAP-1 plays a critical role in the pathophysiology of renal ischemia/reperfusion injury by enhancement of neutrophil infiltration generating a local hydrogen peroxide gradient. | Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M. | 04/7/2018 |
| This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response. | Amine oxidase activity regulates the development of pulmonary fibrosis.
Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M. | 09/16/2017 |
| data indicate that SSAO inactivation in vivo stabilizes the established plaques mainly via inducing the switch of SMCs from a contractile to a synthetic phenotype | Inactivation of Semicarbazide-Sensitive Amine Oxidase Stabilizes the Established Atherosclerotic Lesions via Inducing the Phenotypic Switch of Smooth Muscle Cells.
Peng Y, Wang J, Zhang M, Niu P, Yang M, Yang Y, Zhao Y., Free PMC Article | 08/13/2016 |
| Suggest inhibiting VAP-1/SSAO enzymatic function, by PXS-4728A, as a novel therapeutic approach in lung diseases that are characterized by neutrophilic pattern of inflammation. | Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.
Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W., Free PMC Article | 04/9/2016 |
| these results link the amine oxidase activity of VAP-1 with hepatic inflammation and fibrosis and suggest that targeting VAP-1 has therapeutic potential for NAFLD and other chronic fibrotic liver diseases. | Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH., Free PMC Article | 04/11/2015 |
| these results suggest a largely redundant function for AOC3/VAP-1 in allergic inflammatory responses of the airways. | Endothelial amine oxidase AOC3 transiently contributes to adaptive immune responses in the airways.
Dunkel J, Aguilar-Pimentel JA, Ollert M, Fuchs H, Gailus-Durner V, de Angelis MH, Jalkanen S, Salmi M, Veres TZ. | 03/7/2015 |
| The results of the study establish VCAM-1 and VAP-1 as mediators of myeloid cell recruitment in metastasis and identify VAP-1 as a potential target for therapeutic intervention to combat early metastasis. | VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice.
Ferjančič Š, Gil-Bernabé AM, Hill SA, Allen PD, Richardson P, Sparey T, Savory E, McGuffog J, Muschel RJ. | 06/22/2013 |
| The antihyperglycemic effect of benzylamine is abolished by AOC3 gene knockout in mice. | Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter.
Grès S, Bour S, Valet P, Carpéné C. | 04/27/2013 |
| Long-term activation of semicarbazide-sensitive amine oxidase by benzylamine lowers circulating levels of uric acid in diabetic conditions. | Long-term activation of semicarbazide-sensitive amine oxidase lowers circulating levels of uric acid in diabetic conditions.
Carpéné C, Desquesnes A, Gomez-Ruiz A, Iffiú-Soltész Z, Le Gonidec S, Mercader J. | 12/8/2012 |
| AOC3 expression is increased in perigonadal and subcutaneous adipose tissue of diabetic db-/- obese mice. | Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice.
Iffiú-Soltész Z, Mercader J, Daviaud D, Boucher J, Carpéné C. | 05/26/2012 |
| This review examines the biological functions of VAP-1, especially the role that this molecule might play in the establishment and progression of chronic liver disease. | Hepatic consequences of vascular adhesion protein-1 expression.
Weston CJ, Adams DH. | 05/26/2012 |
| The demonstrated AOC3 turnover of primary amines that are non-native to human tissue suggests possible roles for the adipocyte enzyme in subcutaneous bacterial infiltration and obesity. | Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies.
Shen SH, Wertz DL, Klinman JP., Free PMC Article | 05/19/2012 |
| VAP-1-mediated M2 macrophage infiltration underlies IL-1beta- but not VEGF-A-induced lymph- and angiogenesis | VAP-1-mediated M2 macrophage infiltration underlies IL-1β- but not VEGF-A-induced lymph- and angiogenesis.
Nakao S, Noda K, Zandi S, Sun D, Taher M, Schering A, Xie F, Mashima Y, Hafezi-Moghadam A., Free PMC Article | 07/16/2011 |
| VAP-1 inhibition provided antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage. | Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice.
Ma Q, Manaenko A, Khatibi NH, Chen W, Zhang JH, Tang J., Free PMC Article | 04/30/2011 |
| histamine moderately activated lipolysis in adipocytes in AOC3 knockout mice | Histamine oxidation in mouse adipose tissue is controlled by the AOC3 gene-encoded amine oxidase.
Iffiú-Soltész Z, Wanecq E, Prévot D, Grès S, Carpéné C. | 08/2/2010 |
| LOX binds to mature TGF-beta1 and enzymatically regulates its signaling in bone via amine oxidase activity, and thus may play an important role in bone maintenance and remodeling | Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.
Atsawasuwan P, Mochida Y, Katafuchi M, Kaku M, Fong KS, Csiszar K, Yamauchi M., Free PMC Article | 01/21/2010 |
| VAP-1 regulates the inflammatory response in ischemia-reperfusion injury and suggest that blockade of VAP-1 may have therapeutic value. | Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors.
Kiss J, Jalkanen S, Fülöp F, Savunen T, Salmi M. | 01/21/2010 |