| Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis. | Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis.
Suzuki K, Iwata D, Namba K, Hase K, Hiraoka M, Murata M, Kitaichi N, Foxton R, Ishida S., Free PMC Article | 12/1/2023 |
| Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. | Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment.
Lee E, O'Keefe S, Leong A, Park HR, Varadarajan J, Chowdhury S, Hiner S, Kim S, Shiva A, Friedman RA, Remotti H, Fojo T, Yang HW, Thurston G, Kim M., Free PMC Article | 10/25/2023 |
| Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency. | Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency.
Chatterjee A, Eshwaran R, Huang H, Zhao D, Schmidt M, Wieland T, Feng Y., Free PMC Article | 02/20/2021 |
| Testisin inhibits metastatic ovarian tumor burden and ascites production. Testisin activity antagonizes ANG2 and ANGPTL4 synthesis and secretion. | PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4.
Conway GD, Buzza MS, Martin EW, Duru N, Johnson TA, Peroutka RJ, Pawar NR, Antalis TM., Free PMC Article | 06/27/2020 |
| High ANG2 expression is associated with Acute respiratory distress syndrome. | Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis.
Chen L, Li W, Qi D, Lu L, Zhang Z, Wang D. | 10/20/2018 |
| dual inhibition of VEGFR/Ang-2 prolongs survival in preclinical GBM models by reducing tumor burden, improving normalization, and altering TAMs | Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK., Free PMC Article | 09/3/2016 |
| Ang2 and TNF are essential and synergistic drivers of remodeling of blood vessels and lymphatics during the initial stage of inflammation after infection. Inhibition of Ang2 and TNF together results in widespread suppression of the inflammatory response. | Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.
Le CT, Laidlaw G, Morehouse CA, Naiman B, Brohawn P, Mustelin T, Connor JR, McDonald DM., Free PMC Article | 06/4/2016 |
| These findings implicate YAP as a critical regulator in angiogenesis and provide new insights into the mechanism coordinating junctional stability and angiogenic activation of endothelial cells. | Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2.
Choi HJ, Zhang H, Park H, Choi KS, Lee HW, Agrawal V, Kim YM, Kwon YG. | 05/7/2016 |
| Sonic hedgehog secreted by neurons regulates ang-1 and ang-2 expression in neighboring fibroblasts. | Sonic hedgehog secreted by neurons regulates angiopoietin expression in neighboring fibroblasts.
Kim WJ, Lee SW, Kim KW. | 01/3/2015 |
| Ang-2-VEGF-A CrossMab treatment led to a strong inhibition of angiogenesis and an enhanced vessel maturation phenotype | Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.
Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, Herting F, Yu S, The HH, Martarello L, Gassner C, Stubenrauch KG, Munro K, Augustin HG, Thomas M. | 08/30/2014 |
| Ang2 is secreted from endothelial cells via exosomes and that this process is inhibited by the PI3K/Akt1/endothelial nitric oxide synthase (eNOS) signaling pathway. | Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.
Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M., Free PMC Article | 03/22/2014 |
| The crystal structures of two more murine Ang paralogues, mAng-2 and mAng-3 reveal homology with the human homologues. | Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.
Iyer S, Holloway DE, Acharya KR., Free PMC Article | 03/2/2013 |
| Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group. | Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
Wang JL, Lin YW, Chen HM, Kong X, Xiong H, Shen N, Hong J, Fang JY., Free PMC Article | 02/18/2012 |
| ANG2-TIE2 axis mediates cell-to-cell interactions between TIE2-expressing macrophages (TEMs)and endothelial cells that are important for tumor angiogenesis and can be targeted to induce effective antitumor responses. | Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, De Palma M. | 06/18/2011 |
| FoxC2 and Ang2 are novel targets of Prox1 in mouse embryonic-stem-cell-derived endothelial cells. | Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K. | 03/1/2010 |
| In endothelial cells, endothelial NOS activation per se inhibited LDL oxidation and Ang-2 stimulated NO release in a Tie2-dependent manner to decrease LDL oxidation. | Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.
Ahmed A, Fujisawa T, Niu XL, Ahmad S, Al-Ani B, Chudasama K, Abbas A, Potluri R, Bhandari V, Findley CM, Lam GK, Huang J, Hewett PW, Cudmore M, Kontos CD., Free PMC Article | 01/21/2010 |
| Demonstrate that disturbed ang-2/Tie-2 signaling contributes to the hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis. | Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis.
Tuo QH, Zeng H, Stinnett A, Yu H, Aschner JL, Liao DF, Chen JX. | 01/21/2010 |
| deregulated Ang2 expression during gliomagenesis hinders successful angiogenesis | Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth.
Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF, Bekele BN, Zhou X, Alonso MA, Aldape KD, Fuller GN, Gomez-Manzano C., Free PMC Article | 01/21/2010 |
| focal VEGF and angiopoietin-2 hyperstimulation in the mouse brain increases MMP-9 activity and decreases ZO-1 protein | Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain.
Zhu Y, Lee C, Shen F, Du R, Young WL, Yang GY. | 01/21/2010 |
| Ang-2 may target chemotactic responses to bFGF and VEGF in vivo | Angiogenic synergy of bFGF and VEGF is antagonized by Angiopoietin-2 in a modified in vivo Matrigel assay.
Ley CD, Olsen MW, Lund EL, Kristjansen PE. | 01/21/2010 |
| Improved methods are presented for substantially increased production of mAngrp in a bacterial expression system and for refolding and purification of the protein from inclusion bodies. | High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins.
Holloway DE, Hares MC, Shapiro R, Subramanian V, Acharya KR. | 11/25/2001 |