| [Role of cholinergic anti-inflammatory pathway in Ghrelin regulation of peptide transporter 1 expression in small intestinal epithelium of septic rats]. | [Role of cholinergic anti-inflammatory pathway in Ghrelin regulation of peptide transporter 1 expression in small intestinal epithelium of septic rats].
Shao Z, Hong J, Chen M, Zheng Y, Lin Z, Yang X, Sun R, Liu J. | 01/21/2023 |
| Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule. | Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule.
Alghamdi OA, King N, Andronicos NM, Jones GL, Chami B, Witting PK, Moens PDJ. | 07/2/2022 |
| Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats. | Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats.
Yin H, Shao H, Liu J, Qin Y, Deng W., Free PMC Article | 03/12/2022 |
| Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation. | Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation.
Liang LM, Zhou JJ, Xu F, Liu PH, Qin L, Liu L, Liu XD., Free PMC Article | 07/10/2021 |
| Inhibition of upper small intestinal peptide transporter 1 (PepT1), the primary oligopeptide transporter in the small intestine, reverses the preabsorptive ability of upper small intestinal casein infusion to increase glucose tolerance and suppress glucose production. | Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing.
Dranse HJ, Waise TMZ, Hamr SC, Bauer PV, Abraham MA, Rasmussen BA, Lam TKT., Free PMC Article | 12/22/2018 |
| PepT1 expression was confirmed by immunofluorescence on monolayers and brush border of rat jejunal tissue. | Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models.
Gleeson JP, Brayden DJ, Ryan SM. | 02/24/2018 |
| The expressions of PepT1 mRNA and protein were higher in ghrelin-treated group rats. | Ghrelin upregulates PepT1 activity in the small intestine epithelium of rats with sepsis.
Liu J, Shi B, Shi K, Ma G, Zhang H, Lou X, Liu H, Wan S, Liang D. | 02/18/2017 |
| Slc15a1 is involved in the transport of synthetic F5-peptide into seminiferous epithelium. | Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes.
Su L, Zhang Y, Cheng YC, Lee WM, Ye K, Hu D., Free PMC Article | 09/24/2016 |
| Data suggest that PepT1 transports the vasoactive dipeptide Trp-His (but not His-Trp which undergoes rapid proteolysis) across the rat intestinal membrane; this mechanism may account for anti-atherosclerotic action of Trp-His as a dietary supplement. | Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses.
Tanaka M, Hong SM, Akiyama S, Hu QQ, Matsui T. | 05/21/2016 |
| Nod2-Rip2-NFkappaB signaling involved in the small intestinal inflammatory injury caused by muramyl dipeptide which is transported through PepT1. | Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats.
Ma G, Shi B, Liu J, Zhang H, YinTao Z, Lou X, Liang D, Hou Y, Wan S, Yang W. | 02/6/2016 |
| Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1. | Evaluation of a thiodipeptide, L-phenylalanyl-Ψ[CS-N]-L-alanine, as a novel probe for peptide transporter 1.
Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, Ogihara T. | 10/31/2015 |
| GIP via GIPR activates two signaling pathways, the cAMP pathway through Epac and the PI3K pathway through Akt, to increase the trafficking of PepT1 proteins to the apical membrane. | Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.
Coon SD, Rajendran VM, Schwartz JH, Singh SK., Free PMC Article | 03/7/2015 |
| In the present study, we showed that dietary inorganic phosphorus levels are important factors in the regulation of intestinal PepT1 expression and peptide absorption. | Dietary inorganic phosphorus regulates the intestinal peptide transporter PepT1.
Furutani J, Segawa H, Aranami F, Kuwahara S, Sugano M, Bannai K, Yamato H, Ito M, Miyamoto K. | 09/14/2013 |
| These studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice. | The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.
Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio-Aliaga I, Loh G, Chamaillard M, Haller D, Daniel H. | 09/14/2013 |
| These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells. | Functional expression of SLC15 peptide transporters in rat thyroid follicular cells.
Romano A, Barca A, Kottra G, Daniel H, Storelli C, Verri T. | 07/12/2010 |
| Results suggest that oseltamivir is a substrate of PEPT1 and that PEPT1 is involved in its intestinal absorption. | Oseltamivir (tamiflu) is a substrate of peptide transporter 1.
Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I. | 01/21/2010 |
| Gene expression and transport function of PEPT1 vary diurnally in duodenum and jejunum in temporal association with nocturnal feeding of rats. | Diurnal expression and function of peptide transporter 1 (PEPT1).
Qandeel HG, Duenes JA, Zheng Y, Sarr MG., Free PMC Article | 01/21/2010 |
| DBP has the ability to bind the DBP binding site located in the distal promoter region of the PEPT1 gene & induce the transcriptional activity. These findings indicate that DBP plays pivotal roles in the circadiran oscillation of PEPT1. | Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1).
Saito H, Terada T, Shimakura J, Katsura T, Inui K. | 01/21/2010 |
| Microvilli surface area is preserved through fasting, and apical PepT1 expression increases during both metabolic fasting phases. | Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding.
Habold C, Reichardt F, Foltzer-Jourdainne C, Lignot JH. | 01/21/2010 |
| Acetaldehyde due to consumption of ethanol significantly modulates PEPT1 function and thereby affects drug bioavailability. | Evaluation of the effect of ethanol's toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies.
Fisher SJ, Lee IJ, Swaan PW, Eddington ND. | 01/21/2010 |
| Colitis did not alter PepT-1 substrate bioavailability despite certain modifications in PepT-1 expression profile. | Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis.
Radeva G, Buyse M, Hindlet P, Beaufils B, Walker F, Bado A, Farinotti R. | 01/21/2010 |
| PPARalpha plays critical roles in fasting-induced intestinal PEPT1 expression | Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
Shimakura J, Terada T, Saito H, Katsura T, Inui K. | 01/21/2010 |
| Food intake, rather than the light cycle, greatly affects the diurnal rhythm of SGLT1 and PEPT1 expressions. | The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats.
Pan X, Terada T, Okuda M, Inui K. | 01/21/2010 |
| Up-regulation of PepT1 may adaptively improve absorption of di- and tripeptides, independent of changes in the mucosal surface area | Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury.
Hang CH, Shi JX, Sun BW, Li JS. | 01/21/2010 |
| Products of protein digestion increase spontaneous activity of cholecystokinin-sensitive duodenal vagal afferents via mechanism involving oligopeptide transporter PepT1. | Activation of vagal afferents in the rat duodenum by protein digests requires PepT1.
Darcel NP, Liou AP, Tomé D, Raybould HE. | 01/21/2010 |