| Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection. | Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.
Han L, Zhang F, Liu Y, Yu J, Zhang Q, Ye X, Song H, Zheng C, Han B., Free PMC Article | 06/11/2022 |
| Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia | Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.
Naizhen X, Kido T, Yokoyama S, Linnoila RI, Kimura S., Free PMC Article | 06/13/2020 |
| It has been shown that Scgb3a2 chaperones LPS to the cytosol through the cell surface receptor syndecan-1; this leads to pyroptotic lung cancer cell death driven by caspase-11. | A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death.
Yokoyama S, Cai Y, Murata M, Tomita T, Yoneda M, Xu L, Pilon AL, Cachau RE, Kimura S., Free PMC Article | 03/16/2019 |
| These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. | Secretoglobin Superfamily Protein SCGB3A2 Alleviates House Dust Mite-Induced Allergic Airway Inflammation in Mice.
Yoneda M, Xu L, Kajiyama H, Kawabe S, Paiz J, Ward JM, Kimura S., Free PMC Article | 02/25/2017 |
| The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. | Secretoglobin 3A2 Exhibits Anti-Fibrotic Activity in Bleomycin-Induced Pulmonary Fibrosis Model Mice.
Cai Y, Kimura S., Free PMC Article | 07/2/2016 |
| SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. | Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
Cai Y, Yoneda M, Tomita T, Kurotani R, Okamoto M, Kido T, Abe H, Mitzner W, Guha A, Kimura S., Free PMC Article | 03/19/2016 |
| The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. | Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.
Kido T, Yoneda M, Cai Y, Matsubara T, Ward JM, Kimura S., Free PMC Article | 06/27/2015 |
| SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. | Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
Miyano Y, Tahara S, Sakata I, Sakai T, Abe H, Kimura S, Kurotani R., Free PMC Article | 11/22/2014 |
| Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation | Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.
Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S., Free PMC Article | 08/6/2011 |
| Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. | Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.
Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI, Kimura S., Free PMC Article | 04/2/2011 |
| SCGB3A2 gene may contribute to Graves' disease susceptibility. | Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease.
Song HD, Liang J, Shi JY, Zhao SX, Liu Z, Zhao JJ, Peng YD, Gao GQ, Tao J, Pan CM, Shao L, Cheng F, Wang Y, Yuan GY, Xu C, Han B, Huang W, Chu X, Chen Y, Sheng Y, Li RY, Su Q, Gao L, Jia WP, Jin L, Chen MD, Chen SJ, Chen Z, Chen JL. | 01/21/2010 |
| The expression of SCGB3A1 and SCGB3A2 are bidirectionally regulated by oncostatin M (OSM) when examined in a mouse transformed Clara cell line. | Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.
Tomita T, Yamada A, Miyakoshi M, Kido T, Sheikh F, Srisodsai A, Miyajima A, Donnelly RP, Kimura S., Free PMC Article | 01/21/2010 |
| C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development | CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.
Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S., Free PMC Article | 01/21/2010 |
| To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. | Role of secretoglobin 3A2 in lung development.
Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S., Free PMC Article | 01/21/2010 |
| results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway | Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.
Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S. | 01/21/2010 |
| Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands | Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.
Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K. | 01/21/2010 |
| UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. | Association of uteroglobulin-related protein 1 with bronchial asthma.
Heinzmann A, Dietrich H, Deichmann KA. | 01/21/2010 |
| UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. | Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9.
Chiba Y, Kusakabe T, Kimura S. | 01/21/2010 |