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    Nfasc neurofascin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116690, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The knock down of neurofascin in the basolateral amygdala prevented a priming-induced impairment on long-term potentiation maintenance in the dentate gyrus.

    Neurofascin Knock Down in the Basolateral Amygdala Mediates Resilience of Memory and Plasticity in the Dorsal Dentate Gyrus Under Stress.
    Saha R, Kriebel M, Volkmer H, Richter-Levin G, Albrecht A.

    02/9/2019
    Neurofascin knockdown rats also exhibited impaired learning under stress in the two-way shuttle avoidance task.

    Dentate Gyrus Local Circuit is Implicated in Learning Under Stress--a Role for Neurofascin.
    Zitman FMP, Lucas M, Trinks S, Grosse-Ophoff L, Kriebel M, Volkmer H, Richter-Levin G.

    11/19/2016
    Spreading of the antibody response to neurofascin occurred in demyelinating experimental autoimmune encephalomyelitis

    MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated.
    Flytzani S, Guerreiro-Cacais AO, N'diaye M, Lindner M, Linington C, Meinl E, Stridh P, Jagodic M, Olsson T., Free PMC Article

    03/26/2016
    miR-592 may play a role in neural progenitor cell differentiation and neuronal maturation through regulating Lrrc4c and Nfasc in rat.

    Novel cerebellum-enriched miR-592 may play a role in neural progenitor cell differentiation and neuronal maturation through regulating Lrrc4c and Nfasc in rat.
    Zhang J, Zhang J, Zhou Y, Wu YJ, Ma L, Wang RJ, Huang SQ, Gao RR, Liu LH, Shao ZH, Shi HJ, Cheng LM, Yu L.

    04/12/2014
    overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.

    The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment.
    Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H., Free PMC Article

    09/10/2011
    a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development

    Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
    Kirschbaum K, Kriebel M, Kranz EU, Pötz O, Volkmer H., Free PMC Article

    01/21/2010
    Results describe the differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during peripheral nervous system development

    Differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during PNS development.
    Basak S, Raju K, Babiarz J, Kane-Goldsmith N, Koticha D, Grumet M.

    01/21/2010
    Data show that neurofascin assembles a specialized extracellular matrix at the axon initial segment.

    Neurofascin assembles a specialized extracellular matrix at the axon initial segment.
    Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN., Free PMC Article

    01/21/2010
    antibodies to neurofascin selectively targeted nodes of Ranvier, resulting in deposition of complement, axonal injury, and disease exacerbation

    Neurofascin as a novel target for autoantibody-mediated axonal injury.
    Mathey EK, Derfuss T, Storch MK, Williams KR, Hales K, Woolley DR, Al-Hayani A, Davies SN, Rasband MN, Olsson T, Moldenhauer A, Velhin S, Hohlfeld R, Meinl E, Linington C., Free PMC Article

    01/21/2010
    axonal neurofascin plays a critical role in clustering of Na+ channels at nodes of Ranvier via interactions with receptors on Schwann cells.

    Neurofascin interactions play a critical role in clustering sodium channels, ankyrin G and beta IV spectrin at peripheral nodes of Ranvier.
    Koticha D, Maurel P, Zanazzi G, Kane-Goldsmith N, Basak S, Babiarz J, Salzer J, Grumet M.

    01/21/2010
    The results suggest that the association of Neurofascin 155 to microdomains in the oligodendrocyte membrane is required for its participation in intermolecular interactions, which are important for myelination and/or myelin integrity.

    Alteration of the extracellular matrix interferes with raft association of neurofascin in oligodendrocytes. Potential significance for multiple sclerosis?
    Maier O, van der Heide T, van Dam AM, Baron W, de Vries H, Hoekstra D.

    01/21/2010
    Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction.

    Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction.
    Charles P, Tait S, Faivre-Sarrailh C, Barbin G, Gunn-Moore F, Denisenko-Nehrbass N, Guennoc AM, Girault JA, Brophy PJ, Lubetzki C.

    01/21/2010
    Neurofscin is highly diffusible in young stage 3 neurons all along the axon but becomes restricted in its diffusion in the axonal initial segments coincident with the accumulation of ankyrin G there.

    Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule.
    Boiko T, Vakulenko M, Ewers H, Yap CC, Norden C, Winckler B., Free PMC Article

    01/21/2010
    A novel site of high-density sodium channel clustering in the inner plexiform layer of the retina is described, marked by neurofascin and ankyrin-G.

    Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina.
    Van Wart A, Boiko T, Trimmer JS, Matthews G.

    01/21/2010
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