Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Wei Y, Gao S, Li C, Huang X, Xie B, Geng J, Dai H, Wang C.

Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy.
Zhang Y, Zou R, Abudureyimu M, Liu Q, Ma J, Xu H, Yu W, Yang J, Jia J, Qian S, Wang H, Yang Y, Wang X, Fan X, Ren J., Free PMC Article

Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS.
Xu C, Zhang L, Xu S, Wang Z, Han Q, Lv Y, Wang X, Zhang X, Zhang Q, Zhang Y, He S, Yuan Q, Bian Y, Li C, Wang J, Xu F, Cao Y, Pang J, Chen Y.,

Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.
Gao R, Yang K, Le S, Chen H, Sun X, Dong Z, Gao P, Wang X, Shi J, Qu Y, Wei X, Hu K, Wang J, Jin L, Li Y, Ge J, Sun A.

Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.
Hsu LA, Yeh YH, Chang CJ, Chen WJ, Tsai HY, Chang GJ., Free PMC Article

LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.
Nie X, Fan J, Dai B, Wen Z, Li H, Chen C, Wang DW.

ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
Luo J, Lu Z, Zhong Z, Pi M, Xiong Y, Li L, Chen T, Chen Y, Wang CY, Liu Z, Ye Q.

Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde-potentiated pro-inflammatory responses and glycolysis in macrophages.
Ma H, Lou K, Shu Q, Song X, Xu H.

ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway.
Liu H, Hu Q, Ren K, Wu P, Wang Y, Lv C., Free PMC Article

Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis.
Chen Y, Sun J, Liu J, Wei Y, Wang X, Fang H, Du H, Huang J, Li Q, Ren G, Wang X, Li H., Free PMC Article

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.
Chang YC, Lee HL, Yang W, Hsieh ML, Liu CC, Lee TY, Huang JY, Nong JY, Li FA, Chuang HL, Ding ZZ, Su WL, Chueh LY, Tsai YT, Chen CH, Mochly-Rosen D, Chuang LM., Free PMC Article

ALDH2 activation attenuates oxygen-glucose deprivation/reoxygenation-induced cell apoptosis, pyroptosis, ferroptosis and autophagy.
Qu Y, Liu Y, Zhang H.

[Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier and balances mitochondrial dynamics in mice with acute lung injury].
Wang L, Tian M, Li R, Wu Y, Wang S, Lü H, Liu Z, Yu Y., Free PMC Article

A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice.
Lee AS, Sung YL, Pan SH, Sung KT, Su CH, Ding SL, Lu YJ, Hsieh CL, Chen YF, Liu CC, Chen WY, Chen XR, Chung FP, Wang SW, Chen CH, Mochly-Rosen D, Hung CL, Yeh HI, Lin SF., Free PMC Article

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.
Yao P, Zhang Z, Liu H, Jiang P, Li W, Du W., Free PMC Article

Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway.
Jin J, Chang RS, Xu S, Xia G, Wong JMJ, Fang Y, Jia P, Ding X., Free PMC Article

Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia-Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway.
Chen Y, Xiong Y, Luo J, Hu Q, Lan J, Zou Y, Ma Q, Yao H, Liu Z, Zhong Z, Ye Q., Free PMC Article

Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury.
Li J, Shi X, Chen Z, Xu J, Zhao R, Liu Y, Wen Y, Chen L., Free PMC Article

Loss of ALDH2 aggravates mitochondrial biogenesis disorder in cardiac myocytes induced by TAC.
Xia G, Xu J, Chen M, Jin J, Wang X, Ye Y.

[ALDH2 attenuates LPS-induced increase of brain microvascular endothelial cell permeability by promoting fusion and inhibiting fission of the mitochondria].
Wang S, Lü H, Wang L, Tian M, Gao J, Liu Z, Wang J, Yu Y., Free PMC Article

ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis.
Rungratanawanich W, Lin Y, Wang X, Kawamoto T, Chidambaram SB, Song BJ., Free PMC Article

Aldehyde dehydrogenase 2-associated changes in pharmacokinetics, locomotor function and peripheral glutamic acid and gamma-aminobutyric acid levels during acute alcohol intoxication in male mice.
Li S, Zheng Y, Xiao L, Lan S, Xiang J, Liao L, Lin Y, Ye Y.

ALDH(2) knockout protects against aortic dissection.
Luo C, Zhou B, Cui Y, Liu Z, Wang S., Free PMC Article

Aldehyde dehydrogenase 2 augments adiponectin signaling in coronary angiogenesis in HFpEF associated with diabetes.
Roy B, Pan G, Giri S, Thandavarayan RA, Palaniyandi SS.

Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model.
Cao Z, Qin H, Huang Y, Zhao Y, Chen Z, Hu J, Gao Q., Free PMC Article