| Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis. | Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis.
Tian C, Paskus JD, Fingleton E, Roche KW, Herring BE., Free PMC Article | 11/27/2021 |
| Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity. | Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.
Oku S, Feng H, Connor S, Toledo A, Zhang P, Zhang Y, Thoumine O, Zhang C, Craig AM., Free PMC Article | 02/13/2021 |
| Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation. | Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.
Xia QQ, Xu J, Liao TL, Yu J, Shi L, Xia J, Luo JH, Xu J., Free PMC Article | 06/29/2019 |
| To characterize the possible contribution of NLGN1 to inflammatory pain, the present study analyzed the changes of NLGN1 expression after intraplantar injection of complete Freund's adjuvant (CFA). Our data revealed an activity-dependent recruitment of NLGN1 into synapses, which was essential for NMDAR hyperfunction and pain hypersensitivity. | Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain.
Zhao JY, Duan XL, Yang L, Liu JP, He YT, Guo Z, Hu XD, Suo ZW. | 03/30/2019 |
| downregulation of spinal neuroligin1 expression may ameliorate postoperative pain through inhibiting neuroligin1/PSD-95 interaction and synaptic targeting of GluA1 subunit. | Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Guo R, Li H, Li X, Xue Z, Sun Y, Ma D, Guan Y, Li J, Tian M, Wang Y., Free PMC Article | 10/27/2018 |
| Following endoplasmic reticulum exit, the AMPA-type glutamate receptor GluA1 and neuroligin 1 undergo spatially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes (REs) located in dendrites and spines before reaching the plasma membrane. | Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines.
Bowen AB, Bourke AM, Hiester BG, Hanus C, Kennedy MJ., Free PMC Article | 05/26/2018 |
| We concluded that NLGN1 gene and protein expression is higher in the motor frontal cortex, hippocampus and in the prefrontal cortex in the forced swimming animal model of depression in WKy rats | Hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression.
Feng P, Akladious AA, Hu Y. | 11/18/2017 |
| Neuroligin-1 and neurexin II were both expressed in the Enteric Nervous System (ENS) and have temporal correlation with the development of ENS, during which neuronal intestinal malformations (NIM) may occur due to their disruptions and consequent abnormal ENS development. | Abundance and Significance of Neuroligin-1 and Neurexin II in the Enteric Nervous System of Embryonic Rats.
Wang D, Pan J, Song G, Gao N, Zheng Y, Zhang Q, Li A., Free PMC Article | 02/18/2017 |
| the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. | Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability.
Fang M, Wei JL, Tang B, Liu J, Chen L, Tang ZH, Luo J, Chen GJ, Wang XF. | 10/22/2016 |
| The soluble extracellular fragment of neuroligin-1 protects synapses in neurons damaged by ABETA oligomers. | The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses.
Dinamarca MC, Di Luca M, Godoy JA, Inestrosa NC. | 12/19/2015 |
| Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain. | Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Reissner C, Stahn J, Breuer D, Klose M, Pohlentz G, Mormann M, Missler M., Free PMC Article | 12/20/2014 |
| NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels | Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin.
Samarelli AV, Riccitelli E, Bizzozero L, Silveira TN, Seano G, Pergolizzi M, Vitagliano G, Cascone I, Carpentier G, Bottos A, Primo L, Bussolino F, Arese M., Free PMC Article | 10/4/2014 |
| Neuroligin 1 promotes excitatory synapses in hippocampal pyramidal neurons. | Specific trans-synaptic interaction with inhibitory interneuronal neurexin underlies differential ability of neuroligins to induce functional inhibitory synapses.
Futai K, Doty CD, Baek B, Ryu J, Sheng M., Free PMC Article | 04/27/2013 |
| Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin. | Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin.
Tanaka H, Miyazaki N, Matoba K, Nogi T, Iwasaki K, Takagi J. | 03/9/2013 |
| Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. | Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
Budreck EC, Kwon OB, Jung JH, Baudouin S, Thommen A, Kim HS, Fukazawa Y, Harada H, Tabuchi K, Shigemoto R, Scheiffele P, Kim JH., Free PMC Article | 03/9/2013 |
| This study demomnistrated that the presence of NLGN1 containing the alternatively spliced B site insertion is a requirement for the expression of LTP in young CA1 pyramidal cells at a time when initial synaptic connections are being made in abundance. | A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP.
Shipman SL, Nicoll RA., Free PMC Article | 01/5/2013 |
| Data from studies using cross-linking reagents suggest that neuroligins in neurons cultured from embryonic hippocampus, striatum, or cerebellum form constitutive dimers, including homodimers and, most notably, neuroligin 1/3 heteromers. | Homodimerization and isoform-specific heterodimerization of neuroligins.
Poulopoulos A, Soykan T, Tuffy LP, Hammer M, Varoqueaux F, Brose N. | 11/3/2012 |
| NL1 protein was obtained from the supernatant of the recombinant virus-infected High Five insect cells. It was shown that purified rat NL1 promoted and enhanced the growth rate of axons. | Functional expression of rat neuroligin-1 extracellular fragment by a bi-cistronic baculovirus expression vector.
Chen WS, Villaflores OB, Lu CF, Wu HI, Chen YJ, Teng CY, Chang YC, Chang SL, Wu TY. | 03/3/2012 |
| Data show that knockdown of neuroligin family (Nlgn1, Nlgn2, and Nlgn3)necessary for functional study of cytoplasmic tail. | Functional dependence of neuroligin on a new non-PDZ intracellular domain.
Shipman SL, Schnell E, Hirai T, Chen BS, Roche KW, Nicoll RA., Free PMC Article | 08/20/2011 |
| cadherins and neuroligins can act in concert to regulate synapse formation | N-cadherin and neuroligins cooperate to regulate synapse formation in hippocampal cultures.
Aiga M, Levinson JN, Bamji SX., Free PMC Article | 02/5/2011 |
| A surrogate postsynaptic cell expressing full-length neuroligin-1 triggers slow presynaptic differentiation in a contacting axon. | Alternative splicing of neuroligin regulates the rate of presynaptic differentiation.
Lee H, Dean C, Isacoff E., Free PMC Article | 09/20/2010 |
| the clustering of synaptic vesicles triggered by neuroligin-1 overexpression required the presence of N-cadherin in neurons | Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation.
Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, Dresbach T, Gottmann K., Free PMC Article | 07/19/2010 |
| Findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors. | Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors.
Jung SY, Kim J, Kwon OB, Jung JH, An K, Jeong AY, Lee CJ, Choi YB, Bailey CH, Kandel ER, Kim JH., Free PMC Article | 05/31/2010 |
| the excitatory, postsynaptic neuronal cell-adhesion receptor, neuroligin-1, was found to be significantly increased in both the prefrontal and parietal cortical areas of aged cognitively impaired rats. | Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status.
Majdi M, Ribeiro-da-Silva A, Cuello AC. | 01/21/2010 |
| Data show beta-cell expression of the neuroligin 1, and show that neuroligin expression affects insulin secretion in INS-1 beta-cells and rat islet cells. | Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.
Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD., Free PMC Article | 01/21/2010 |