| Tenascin C activates the toll-like receptor 4/NF-kappaB signaling pathway to promote the development of polycystic ovary syndrome. | Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome.
Wu H, Yang M, Yan C, Liu M, Wang H, Zhang W., Free PMC Article | 04/30/2024 |
| Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers. | Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
Kolanowski TJ, Wargocka-Matuszewska W, Zimna A, Cheda L, Zyprych-Walczak J, Rugowska A, Drabik M, Fiedorowicz M, Krajewski S, Steczek Ł, Kozanecki C, Rogulski Z, Rozwadowska N, Kurpisz M., Free PMC Article | 12/18/2021 |
| TNC gene silencing relieved neuronal apoptosis and neuroinflammation by activating the PI3K/Akt/ NF-kappaB signaling pathway in subarachnoid hemorrhage. | Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF-κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model.
Tong X, Zhang J, Shen M, Zhang J. | 02/15/2020 |
| This study aimed to investigate the role of TNC and CCN3 as prognostic factors for post hepatectomy liver failure (PHLF) in a rat model of partial hepatectomy and 50 patients following partial hepatectomy. | The Predictive Role of Tenascin-C and Cellular Communication Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat Model and 50 Patients Following Partial Hepatectomy.
Li H, Ge X, Pan K, Sui M, Cai H, Cui C, Li C, Lu S., Free PMC Article | 02/15/2020 |
| these results indicated that in an indirect coculture system, pelvic ligament fibroblasts with mechanical stretch stimulation may promote the synthesis of tenascinC and BMSC differentiation into pelvic ligament fibroblasts. | Tenascin-C expression and its associated pathway in BMSCs following co-culture with mechanically stretched ligament fibroblasts.
Zhao B, Hu M, Wu H, Ren C, Wang J, Cui S., Free PMC Article | 02/24/2018 |
| Epicardium-derived cells (EPDCs) from post-myocardial infarction hearts highly expressed tenascin-C, which induces pro-IL-1beta transcription in EPDCs and thus contributes to inflammasome activation. | CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction.
Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J. | 09/23/2017 |
| tenascin-C and phosphacan represent early indicators of neurodegeneration. | Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model.
Reinehr S, Reinhard J, Wiemann S, Stute G, Kuehn S, Woestmann J, Dick HB, Faissner A, Joachim SC., Free PMC Article | 07/1/2017 |
| In a liver fibrosis cellular model, tenascin-C promotes migration of hepatic stellate cells and production of type I collagen via TGF-beta1 and alpha9beta1 integrin pathway. | Tenascin-C promotes migration of hepatic stellate cells and production of type I collagen.
Ma JC, Huang X, Shen YW, Zheng C, Su QH, Xu JK, Zhao J. | 01/28/2017 |
| Co-localization of tenascin-C and fibronectin immunoreactivity was observed in many regions | Immunohistochemical localization of tenascin-C in rat periodontal ligament with reference to alveolar bone remodeling.
Sato R, Fukuoka H, Yokohama-Tamaki T, Kaku M, Shibata S. | 01/14/2017 |
| the D/P Cr ratio was correlated with effluent levels of TN-C (rho = 0.57, p < 0.001) and MMP-2 (rho = 0.73, p < 0.001). We suggest that TN-C in the effluents may be a diagnostic marker for peritoneal deterioration with EMT-like change | Effluent Tenascin-C Levels Reflect Peritoneal Deterioration in Peritoneal Dialysis: MAJOR IN PD Study.
Hirahara I, Kusano E, Imai T, Morishita Y, Inoue M, Akimoto T, Saito O, Muto S, Nagata D., Free PMC Article | 10/1/2016 |
| Results show that TNC upregulation is mediated in part by activation of TGF-beta signaling pathway, which support the idea that misregulation of this signaling pathway produces changes that may contribute to disease | Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model.
Mercado-Gómez O, Landgrave-Gómez J, Arriaga-Avila V, Nebreda-Corona A, Guevara-Guzmán R. | 08/8/2015 |
| Tenascin-C and type I collagen may participate in the morphogenesis of ovarian follicles, and in the formation and regression of corpora lutea. | Temporal expression of tenascin-C and type I collagen in response to gonadotropins in the immature rat ovary.
Bagavandoss P. | 05/23/2015 |
| LED irradiation modulates positively the expression of tenascin and particularly fibronectin. | Infrared LED light therapy influences the expression of fibronectin and tenascin in skin wounds of malnourished rats--a preliminary study.
de Sousa AP, Gurgel CA, Ramos EA, Trindade RF, de Faro Valverde L, Carneiro TS, Cangussú MC, Pinheiro AL, Dos Santos JN. | 05/23/2015 |
| Data show that expression of tenascin-C (TNC), matrix metalloproteinase-9 (MMP-9), transforming growth factorbeta1 (TGF-beta1), connective tissue growth factor (CTGF) and alpha smooth muscle cell actin (alphaSMA) peaked at 2 weeks post-immunization. | Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis.
Matsumoto Y, Niimi N, Kohyama K. | 04/6/2013 |
| Seven alternatively spliced fibronectin type III domains of tenascin-Cexist in rat and the differential expression pattern of the additional domain AD1 during embryonic and postnatal rat brain development, is described. | Existence of tenascin-C isoforms in rat that contain the alternatively spliced AD1 domain are developmentally regulated during hippocampal development.
Garwood J, Theocharidis U, Calco V, Dobbertin A, Faissner A. | 09/1/2012 |
| TNC coated on substrate promotes platelet-derived growth factor-BB-induced proliferation and migration of rat vascular smooth muscle cell line. | Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.
Ishigaki T, Imanaka-Yoshida K, Shimojo N, Matsushima S, Taki W, Yoshida T. | 10/15/2011 |
| These findings might contribute to gain mechanistic insights into the regulation of TN-C formation after myocardial infarction. | Cardiac extracellular matrix tenascin-C deposition during fibronectin degradation.
Ma S, Yang D, Li D, Tang B, Sun M, Yang Y. | 08/13/2011 |
| Complex injury-induced differential regulation of Tnc isoforms are identified that may well influence axonal regeneration and repair processes in the damaged central nervous system after traumatic injury. | Analysis of combinatorial variability reveals selective accumulation of the fibronectin type III domains B and D of tenascin-C in injured brain.
Dobbertin A, Czvitkovich S, Theocharidis U, Garwood J, Andrews MR, Properzi F, Lin R, Fawcett JW, Faissner A. | 10/23/2010 |
| In rats with aneurysmal subarachnoid hemorrhage, marked induction of TN-C immunoreactivity is shown throughout the vasospastic arterial wall, especially in the smooth muscle cell layers, in comparison with control rats. | Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans: a pilot study.
Suzuki H, Kanamaru K, Suzuki Y, Aimi Y, Matsubara N, Araki T, Takayasu M, Kinoshita N, Imanaka-Yoshida K, Yoshida T, Taki W. | 09/27/2010 |
| analysis of tenascin distribution in rat submandibular glands following irradiation | Expression and distribution of tenascin in rat submandibular glands following irradiation.
Bartel-Friedrich S, Lautenschläger C, Holzhausen HJ, Friedrich RE. | 07/19/2010 |
| Compared tenascin C and tenascin R in oligodendrocyte differentiation. Tnc and Tnr play antagonistic roles for differentiation and comparably inhibit morphologic maturation. conclude that independent molecular pathways regulate these processes. | Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.
Czopka T, Von Holst A, Schmidt G, Ffrench-Constant C, Faissner A. | 01/21/2010 |
| Pressure overloda-induced rigth ventricular failure is associated with re-expression of myocardial Tnc and elevated plasma Tnc levels. | Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A. | 01/21/2010 |
| Data suggests that cyclic stretching promotes the synthesis of collagen types I and III and tenascin-C by the rat bone mesenchymal stem cells. | Effect of uniaxial stretching on rat bone mesenchymal stem cell: orientation and expressions of collagen types I and III and tenascin-C.
Zhang L, Kahn CJ, Chen HQ, Tran N, Wang X. | 01/21/2010 |
| Tn-C isoforms are expressed in a regulated fashion in vascular system. Our findings suggest a new role of Tn-C isoforms in the remodeling of vascular wall. | Balloon catheterization induces arterial expression of new Tenascin-C isoform.
Wallner K, Shah PK, Sharifi BG. | 01/21/2010 |
| Level of thrombospondin paralleled that of MMP-2 in small arteries, whereas tenascin-C levels declined rapidly and stayed below control values. | Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Bouvet C, Gilbert LA, Girardot D, deBlois D, Moreau P. | 01/21/2010 |