| Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclasedagger. | Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase†.
Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA., Free PMC Article | 01/26/2024 |
| We conclude that FGF rapidly inactivates GC-B by a reversible dephosphorylation mechanism, which may contribute to the signaling network by which activated FGFR3 causes dwarfism. | Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Robinson JW, Egbert JR, Davydova J, Schmidt H, Jaffe LA, Potter LR., Free PMC Article | 06/16/2018 |
| Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats. | Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
Lu J, Pan SS., Free PMC Article | 03/24/2018 |
| C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation. | C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, Özcelik C, Paterson DJ, Bader M, Herring N., Free PMC Article | 10/14/2017 |
| Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro. | Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.
Manivasagam S, Vellaichamy E. | 08/26/2017 |
| Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the luteinizing hormone-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. | Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Egbert JR, Shuhaibar LC, Edmund AB, Van Helden DA, Robinson JW, Uliasz TF, Baena V, Geerts A, Wunder F, Potter LR, Jaffe LA., Free PMC Article | 11/8/2014 |
| These data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes. | Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.
Thompson IR, Mirczuk SM, Smith L, Lessey AJ, Simbi B, Sunters A, Baxter GF, Lipscomb VJ, McGonnell IM, Wheeler-Jones CP, Mukherjee A, Roberson MS, McArdle CA, Fowkes RC., Free PMC Article | 10/4/2014 |
| Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion. | Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Sun F, Zhou K, Wang SJ, Liang PF, Zhu MZ, Qiu JH. | 10/4/2014 |
| Six phosphorylation sites were identified in rat GC-B (S513, T516, S518, S523, S526, and T529), and all six sites were also identified in human GC-B. | Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.
Yoder AR, Stone MD, Griffin TJ, Potter LR., Free PMC Article | 01/1/2011 |
| At postnatal day 1, the vast majority of GC-B (but not GC-A) molecules contain additionally an O-linked carbohydrate modification of about 1 kDa in mass and a further modification of similar size which is resistant to enzymatic removal. | The membrane receptors guanylyl cyclase-A and -B undergo distinctive changes in post-translational modification during brain development.
Müller D, Hildebrand M, Lübberstedt J, Kuhn M, Middendorff R. | 11/27/2010 |
| results demonstrate that NPRs are clearly expressed in the cells located in the ganglion cell layer including the three major subtypes of retinal ganglion cells and the expression is mainly on the membrane of somata | Natriuretic peptide receptors are expressed in rat retinal ganglion cells.
Xu GZ, Tian J, Zhong YM, Yang XL. | 10/23/2010 |
| Results show that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B. | Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.
Buttgereit J, Qadri F, Monti J, Langenickel TH, Dietz R, Braunewell KH, Bader M. | 08/2/2010 |
| The data suggest that in our left ventricular hypertrophy model, the NPR-A and NPR-C receptors were increased in association to the increased BNP level. | B-type natriuretic peptide receptors in hypertrophied adult rat cardiomyocytes.
Nader L, Lahoud L, Chouery E, Aftimos G, Bois P, Farès NA. | 06/14/2010 |
| Study revealed that GC-B predominates in the developing and GC-A in the adult brain, with regional differences each between cerebral cortex, cerebellum, and brain stem. | Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis.
Müller D, Hida B, Guidone G, Speth RC, Michurina TV, Enikolopov G, Middendorff R. | 01/25/2010 |
| Deregulation of NPR-2 function in astrocytes by ammonia may contribute to neurophysiological symptoms of hyperammonemia. | Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices.
Zielińska M, Fresko I, Konopacka A, Felipo V, Albrecht J. | 01/21/2010 |
| hyperosmotic and lysophosphatidic acid-dependent inhibition of NPRB is mediated by calcium-dependent phosphorylation | Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B.
Potthast R, Abbey-Hosch SE, Antos LK, Marchant JS, Kuhn M, Potter LR. | 01/21/2010 |
| CNP is capable of autoregulating the expression of its cognate receptor, type B natriuretic peptide receptor. | C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells.
Rahmutula D, Gardner DG. | 01/21/2010 |
| The data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR-A and NPR-C in the left ventricle. | Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
Christoffersen TE, Aplin M, Strom CC, Sheikh SP, Skott O, Busk PK, Haunso S, Nielsen LB. | 01/21/2010 |
| investigated the localization and function of the CNP receptor NPR-B (or GC-B) in the adult rat heart ventricle; found the expression of GC-B is predominantly in nonmyocytes. | Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.
Doyle DD, Upshaw-Earley J, Bell EL, Palfrey HC. | 01/21/2010 |