| Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. | Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
van Wijk K, Akabane T, Kimura T, Saitoh S, Okano S, Kelly VP, Takagi M, Kodama K, Takahashi K, Tanaka T, Nakajima M, Nakajima O. | 02/6/2021 |
| RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice. | RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.
Yasuda M, Gan L, Chen B, Kadirvel S, Yu C, Phillips JD, New MI, Liebow A, Fitzgerald K, Querbes W, Desnick RJ., Free PMC Article | 09/6/2014 |
| Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels. | ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.
Oliveri LM, Davio C, Batlle AM, Gerez EN. | 04/14/2012 |
| active site functional asymmetry extends to chimeric ALAS/AONS proteins, which while having a different oligomeric state, exhibit different rates of product release from the two ALAS and two AONS active sites due to the created intermolecular strain | Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase.
Turbeville TD, Zhang J, Adams WC, Hunter GA, Ferreira GC., Free PMC Article | 08/27/2011 |
| Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme | Egr-1 regulates the transcriptional repression of mouse δ-aminolevulinic acid synthase 1 by heme.
Gotoh S, Nakamura T, Kataoka T, Taketani S. | 02/26/2011 |
| Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis. | Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse.
Okano S, Zhou L, Kusaka T, Shibata K, Shimizu K, Gao X, Kikuchi Y, Togashi Y, Hosoya T, Takahashi S, Nakajima O, Yamamoto M. | 05/31/2010 |
| Ser-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA binding to enzyme conformational equilibria | Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase.
Lendrihas T, Hunter GA, Ferreira GC., Free PMC Article | 03/1/2010 |
| The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression. | B2 SINE retrotransposon causes polymorphic expression of mouse 5-aminolevulinic acid synthase 1 gene.
Chernova T, Higginson FM, Davies R, Smith AG. | 01/21/2010 |
| 5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan's hypothesis | Transient kinetic studies support refinements to the chemical and kinetic mechanisms of aminolevulinate synthase.
Hunter GA, Zhang J, Ferreira GC. | 01/21/2010 |
| identified a drug-responsive enhancer in the ALAS1 gene | Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene.
Fraser DJ, Zumsteg A, Meyer UA. | 01/21/2010 |
| Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP)-binding and catalysis. | Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis.
Turbeville TD, Zhang J, Hunter GA, Ferreira GC., Free PMC Article | 01/21/2010 |