| Mitochondrial dysfunction reactivates alpha-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. | Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Jett KA, Baker ZN, Hossain A, Boulet A, Cobine PA, Ghosh S, Ng P, Yilmaz O, Barreto K, DeCoteau J, Mochoruk K, Ioannou GN, Savard C, Yuan S, Abdalla OH, Lowden C, Kim BE, Cheng HM, Battersby BJ, Gohil VM, Leary SC., Free PMC Article | 01/11/2023 |
| Blocking estrogen-induced AMH expression is crucial for normal follicle formation. | Blocking estrogen-induced AMH expression is crucial for normal follicle formation.
Tanimoto R, Sekii K, Morohaku K, Li J, Pépin D, Obata Y., Free PMC Article | 09/18/2021 |
| endogenous AFP expression in the perinatal liver is reduced in the absence of beta-catenin, suggesting that beta-catenin regulates AFP during liver development. | Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice.
Clinkenbeard EL, Butler JE, Spear BT., Free PMC Article | 01/26/2013 |
| Findings indicate that AFP expressed under experimental cryptorchid conditions plays a role as a regulatory factor in spermatogenesis and in hepatic generation. | Unexpected role of α-fetoprotein in spermatogenesis.
Yazama F, Tai A., Free PMC Article | 10/29/2011 |
| AFP mRNA and VEGF-C mRNA in peripheral blood were significantly correlated with recurrence and metastasis of hepatocellular carcinoma. | [The effect of allogenic hematopoietic stem cell transplantation on tumor recurrence and metastasis of hepatocellular carcinoma after hepatectomy and the relationship with presence of AFP mRNA and VEGF-C mRNA in peripheral blood].
Deng ZG, Li B, Zu C. | 06/4/2011 |
| A DEHP treatment-induced phenotype was identified with lack of glycogen accumula-tion and intracytoplasmic localization of beta-catenin which was associated with increased AFP gene expression. | In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice.
Maranghi F, Lorenzetti S, Tassinari R, Moracci G, Tassinari V, Marcoccia D, Di Virgilio A, Eusepi A, Romeo A, Magrelli A, Salvatore M, Tosto F, Viganotti M, Antoccia A, Di Masi A, Azzalin G, Tanzarella C, Macino G, Taruscio D, Mantovani A. | 09/27/2010 |
| The deficits observed in parental behavior of AFP knockout females could not be explained by any changes in olfactory function, novelty recognition or anxiety | The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.
Keller M, Pawluski JL, Brock O, Douhard Q, Bakker J., Free PMC Article | 07/5/2010 |
| Foxa1 acts as a pioneer transcription factor in de novo activation of Afp, by exploiting a lack of methylation at juxtaposed transposed elements | Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells.
Taube JH, Allton K, Duncan SA, Shen L, Barton MC., Free PMC Article | 06/28/2010 |
| data indicate that this enhancer region is required for alpha-fetoprotein and albumin activation early in liver development and alpha-fetoprotein reactivation during liver regeneration | The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.
Jin L, Long L, Green MA, Spear BT., Free PMC Article | 01/21/2010 |
| The sex difference in the ability to show preovulatory LH surges depends on the prenatal actions of estrogens in the male hypothalamus, is lost in Afp(-/-) females. | Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges.
González-Martínez D, De Mees C, Douhard Q, Szpirer C, Bakker J., Free PMC Article | 01/21/2010 |
| mouse and human alpha-fetoprotein enhancers are strikingly different | Striking differences between the mouse and the human alpha-fetoprotein enhancers.
Long L, Davidson JN, Spear BT. | 01/21/2010 |
| AFP has a role in female fertility, but not in male fertility or survival, in mice | Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.
Gabant P, Forrester L, Nichols J, Van Reeth T, De Mees C, Pajack B, Watt A, Smitz J, Alexandre H, Szpirer C, Szpirer J., Free PMC Article | 01/21/2010 |
| The level of AFP mRNA in peripheral blood may indicate recurrence and/or metastasis after curative resection of hepatocellular carcinoma. | [Quantitation of alpha-fetoprotein messenger RNA in peripheral blood of nude mice and its relationship with tumor recurrence and metastasis after curative resection of hepatocellular carcinoma].
Wu X, Lin Z, Fan J, Lu J, Wang L, Tang Z. | 01/21/2010 |
| AFP affects cell proliferation by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras p21 genes | The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells.
Li MS, Li PF, Yang FY, He SP, Du GG, Li G. | 01/21/2010 |
| 30-kDa protein is a novel isoform of AUF1 family and is the main component of the DAP-II complex that binds to the DAS sequence | AUF1-like protein binds specifically to DAS cis-acting element that regulates mouse alpha-fetoprotein gene expression.
Jiao R, He QY, Chen H, Hua Z, Jiao Q, Chiu JF. | 01/21/2010 |
| The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 | The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA).
Huang MC, Li KK, Spear BT., Free PMC Article | 01/21/2010 |
| AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation | Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action.
De Mees C, Laes JF, Bakker J, Smitz J, Hennuy B, Van Vooren P, Gabant P, Szpirer J, Szpirer C., Free PMC Article | 01/21/2010 |
| A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor. | Regulation of alpha-fetoprotein expression by Nkx2.8.
Kajiyama Y, Tian J, Locker J., Free PMC Article | 01/21/2010 |