| Differential Downregulation of beta1-Adrenergic Receptor Signaling in the Heart. | Differential Downregulation of β(1)-Adrenergic Receptor Signaling in the Heart.
Xu B, Bahriz S, Salemme VR, Wang Y, Zhu C, Zhao M, Xiang YK., Free PMC Article | 06/28/2024 |
| Protective effects of Galphai3 deficiency in a murine heart-failure model of beta1-adrenoceptor overexpression. | Protective effects of Gα(i3) deficiency in a murine heart-failure model of β(1)-adrenoceptor overexpression.
Schröper T, Mehrkens D, Leiss V, Tellkamp F, Engelhardt S, Herzig S, Birnbaumer L, Nürnberg B, Matthes J., Free PMC Article | 03/15/2024 |
| Epac1 participates in beta1-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes. | Epac1 participates in β(1)-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes.
Li Y, Tian Y, Shi S, Hou X, Hao H, Ma M, Ning N, Yuan Y, Wang X, Liu H, Wang L. | 08/19/2023 |
| Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice. | Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice.
Wang J, Venugopal J, Silaghi P, Su EJ, Guo C, Lawrence DA, Eitzman DT., Free PMC Article | 05/30/2023 |
| Pharmacological activation of the C5a receptor leads to stimulation of the beta-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease. | Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Fella E, Papacharalambous R, Kynigopoulos D, Ioannou M, Derua R, Christodoulou C, Stylianou M, Karaiskos C, Kagiava A, Petroula G, Pierides C, Kyriakou M, Koumas L, Costeas P, Panayiotou E., Free PMC Article | 10/1/2022 |
| N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes. | N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes.
Lu KY, Primus Dass KT, Lin SZ, Tseng YH, Liu SP, Harn HJ. | 01/8/2022 |
| Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute beta-Adrenergic Receptor Stimulation In Vivo. | Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute β-Adrenergic Receptor Stimulation In Vivo.
Güran A, Ji Y, Fang P, Pan KT, Urlaub H, Avkiran M, Lenz C., Free PMC Article | 12/18/2021 |
| Intracellular beta1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. | Intracellular β(1)-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility.
Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK., Free PMC Article | 07/31/2021 |
| Data indicate that G protein-coupled estrogen receptor 1 (GPER) functions as an intrinsic component of adrenergic receptor beta 1 (beta1AR) signaling to moderate myocardial Ca(2+) dynamics and contraction. | Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1.
Whitcomb V, Wauson E, Christian D, Clayton S, Giles J, Tran QK., Free PMC Article | 08/1/2020 |
| the findings of the present study indicate that stimulation of a1 - and b1/2 -ARs markedly reduced serum TG steady-state levels as a result of alterations in TG synthesis, uptake, transport, hydrolysis, metabolism and clearance, an effect induced by PPARa independent mechanisms | Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.
Konstandi M, Kypreos KE, Matsubara T, Xepapadaki E, Shah YM, Krausz K, Andriopoulou CE, Kofinas A, Gonzalez FJ., Free PMC Article | 06/13/2020 |
| Mice carrying the beta1AR A187V mutation demonstrated short sleep behavior. This receptor is highly expressed in the dorsal pons and that these ADRB1(+) neurons are active during rapid eye movement (REM) sleep and wakefulness. | A Rare Mutation of β(1)-Adrenergic Receptor Affects Sleep/Wake Behaviors.
Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptáček LJ, Fu YH., Free PMC Article | 03/28/2020 |
| Beta1-adrenergic receptor autoantibody induces cardiac remodeling by activating t-lymphocytes. | Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling.
Du Y, Li X, Yu H, Yan L, Lau WB, Zhang S, Qin Y, Wang W, Ma X, Liu H, Fu M. | 02/22/2020 |
| beta1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress. | β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.
Gupta D, Chuang JC, Mani BK, Shankar K, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Zigman JM., Free PMC Article | 12/14/2019 |
| USP20 regulates beta1AR signaling in vitro and in vivo Additionally, beta1AR-induced USP20 phosphorylation may serve as a feed-forward mechanism to stabilize beta1AR expression and signaling during pathological insults to the myocardium. | The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β(1)-adrenergic receptor expression and signaling.
Yu SM, Jean-Charles PY, Abraham DM, Kaur S, Gareri C, Mao L, Rockman HA, Shenoy SK., Free PMC Article | 05/4/2019 |
| Cardiac specific expression of the mutated Cav1.2PKA_P2(-/-) gene reduces Cav1.2 alpha1c protein concentration, calcium current (ICa), and the beta-adrenergic stimulation of L-type ICa in cardiomyocytes. | Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel.
Poomvanicha M, Matthes J, Domes K, Patrucco E, Angermeier E, Laugwitz KL, Schneider T, Hofmann F. | 05/19/2018 |
| Proliferation in cardiac fibroblasts induced by beta1-adrenoceptor autoantibody results in endomyocardial fibrosis. | Proliferation in cardiac fibroblasts induced by β1-adrenoceptor autoantibody and the underlying mechanisms.
Lv T, Du Y, Cao N, Zhang S, Gong Y, Bai Y, Wang W, Liu H., Free PMC Article | 05/19/2018 |
| the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins. | G protein, phosphorylated-GATA4 and VEGF expression in the hearts of transgenic mice overexpressing β1- and β2-adrenergic receptors.
Tae HJ, Petrashevskaya N, Kim IH, Park JH, Lee JC, Won MH, Kim YH, Ahn JH, Park J, Choi SY, Jeon YH., Free PMC Article | 03/10/2018 |
| ghrelin has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR | β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.
Mani BK, Osborne-Lawrence S, Vijayaraghavan P, Hepler C, Zigman JM., Free PMC Article | 09/30/2017 |
| knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. | β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints.
Gao X, Zhao Y, Su Y, Liu K, Yu X, Cui C, Yang Z, Shi H, Jing X, Zhu B., Free PMC Article | 07/8/2017 |
| Computer simulations model the responses to moderate stimulation/inhibition of the beta1-adrenergic signaling system and its components in mouse ventricular myocytes. | Simulation of the effects of moderate stimulation/inhibition of the β1-adrenergic signaling system and its components in mouse ventricular myocytes.
Grinshpon M, Bondarenko VE. | 06/3/2017 |
| Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. | BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.
Feldman AM, Gordon J, Wang J, Song J, Zhang XQ, Myers VD, Tilley DG, Gao E, Hoffman NE, Tomar D, Madesh M, Rabinowitz J, Koch WJ, Su F, Khalili K, Cheung JY., Free PMC Article | 12/17/2016 |
| Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy. | Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.
Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J., Free PMC Article | 09/17/2016 |
| Knockout of the C5aR1 attenuated the effect of beta1-AR in the heart, suggesting an association between the beta1-AR and C5aR1, although further investigation is required to determine if this is a direct or causal association | A Potential Link between the C5a Receptor 1 and the β1-Adrenoreceptor in the Mouse Heart.
Khor KH, Moore TA, Shiels IA, Greer RM, Arumugam TV, Mills PC., Free PMC Article | 07/16/2016 |
| The beta1-AR may play an important role in the development of atrial fibrillation. | Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.
Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y., Free PMC Article | 05/7/2016 |
| Partial gap junction uncoupling increased propensity and amplitude of Ca(2+) alternans, and made them more sensitive to reversal by beta-AR activation, as in isolated myocytes. | Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.
Hammer KP, Ljubojevic S, Ripplinger CM, Pieske BM, Bers DM., Free PMC Article | 04/9/2016 |