| Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor alpha2A. | Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α(2A).
Ten Hove AS, Mallesh S, Zafeiropoulou K, de Kleer JWM, van Hamersveld PHP, Welting O, Hakvoort TBM, Wehner S, Seppen J, de Jonge WJ., Free PMC Article | 11/1/2023 |
| The alpha2-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism. | The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
Sandrini L, Amadio P, Ieraci A, Malara A, Werba JP, Soprano PM, Balduini A, Zarà M, Bonomi A, Veglia F, Colombo GI, Popoli M, Lee FS, Tremoli E, Barbieri SS. | 05/21/2022 |
| Heteromerization between alpha2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders. | Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Casadó-Anguera V, Moreno E, Sánchez-Soto M, Cai NS, Bonaventura J, Homar-Ruano P, Rubinstein M, Cortés A, Canela EI, Ferré S, Casadó V., Free PMC Article | 02/12/2022 |
| Role of alpha2-Adrenoceptor Subtypes in Suppression of L-Type Ca(2+) Current in Mouse Cardiac Myocytes. | Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca(2+) Current in Mouse Cardiac Myocytes.
Evdokimovskii EV, Jeon R, Park S, Pimenov OY, Alekseev AE., Free PMC Article | 05/15/2021 |
| alpha2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome. | α2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome.
Cong Z, Li D, Lv X, Yang C, Zhang Q, Wu C, Wang Z, Zhu X. | 12/26/2020 |
| The in vivo specificity of synaptic Gbeta and Ggamma subunits to the alpha2a adrenergic receptor at CNS synapses. | The in vivo specificity of synaptic Gβ and Gγ subunits to the α(2a) adrenergic receptor at CNS synapses.
Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm HE., Free PMC Article | 08/29/2020 |
| Study shows that dorsal BNST alpha2A-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors. | Dorsal BNST α(2A)-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG., Free PMC Article | 10/12/2019 |
| Lack of alpha2A-ARs protects from diet-induced obesity and type 2 diabetes (T2D). Blockade of alpha2A-ARs may be exploited to reduce visceral fat and to improve insulin secretion. | Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors.
Ruohonen ST, Valve L, Tuomainen K, Ailanen L, Röyttä M, Manz G, Baur N, Joos TO, Savontaus E, Scheinin M. | 09/28/2019 |
| We show that these neurons are dispensable for regulating food intake, but are required for coordinating hepatic glucose production and for the fasting-induced fall in leptin levels, independent of changes in fat mass. We also identify a role for sympathetic nervous system regulation of the inhibitory adrenergic receptor (ADRA2A) in regulating leptin production. | POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels.
Caron A, Dungan Lemko HM, Castorena CM, Fujikawa T, Lee S, Lord CC, Ahmed N, Lee CE, Holland WL, Liu C, Elmquist JK., Free PMC Article | 07/6/2019 |
| Study showed that alpha2A adrenergic receptors are highly expressed in the cell bodies and axons of mesoprefrontal dopaminergic neurons provides a morphological basis to the vast functional evidence that somatodendritic and nerve-terminal alpha2A adrenergic receptors control dopaminergic activity and dopamine release in the prefrontal cortex. | α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons.
Castelli MP, Spiga S, Perra A, Madeddu C, Mulas G, Ennas MG, Gessa GL. | 09/9/2017 |
| Results suggested that nicotine produces anxiogenic-like behaviors which may be mediated through a basolateral amygdala alpha2-adrenoceptor mechanism | Modulatory effects of the basolateral amygdala α2-adrenoceptors on nicotine-induced anxiogenic-like behaviours of rats in the elevated plus maze.
Bashiri H, Rezayof A, Sahebgharani M, Tavangar SM, Zarrindast MR. | 06/24/2017 |
| The current study demonstrated that a physiological concentration of adrenaline attenuates insulin release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling. | Endogenous α2A-Adrenoceptor-Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling.
Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M. | 06/10/2017 |
| Results suggest that slow ventral root potential suppression by dexmedetomidine and xylazine is mainly mediated by alpha2A-AR. | Contribution of α2A-adrenoceptor subtype to effect of dexmedetomidine and xylazine on spinal synaptic transmission of mice.
Kobayashi T, Otsuguro K, Yamaguchi S, Ito S. | 05/21/2016 |
| The study suggests that a2-adrenoreceptors/catecholamine play pivotal role in psychological stress-induced colitis. | Catecholamine Mediates Psychological Stress-Induced Colitis Through a2-Adrenoreceptor.
Bai A, Chen J, Liao W, Lu N, Guo Y. | 04/9/2016 |
| This study showed that reduced expression of the alpha2A-adrenoceptor (Adra2a) which modulate antidepressant action in hippocampus. | Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
Husain BF, Nanavaty IN, Marathe SV, Rajendran R, Vaidya VA. | 02/20/2016 |
| Adra2a is expressed in the mesenchyme of the mouse stomach primordium at E11.5. Fzd5 and Trpv6 are expressed in the epithelial layer of the stomach primordium after E11.5. | Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.
Noguchi TK, Ishimine H, Nakajima Y, Watanabe-Susaki K, Shigeta N, Yamakawa N, Wang PC, Asashima M, Kurisaki A, Noguchi TK, Ishimine H, Nakajima Y, Watanabe-Susaki K, Shigeta N, Yamakawa N, Wang PC, Asashima M, Kurisaki A. | 10/27/2015 |
| Fzd5 and Trvp6 are expressed in the epithelial layer of the prospective pyroric and glandular stomach, respectively and Adra2a is expressed in the mesenchymal region of the stomach primordium at the beginning of morphogenesis. | Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.
Noguchi TK, Ishimine H, Nakajima Y, Watanabe-Susaki K, Shigeta N, Yamakawa N, Wang PC, Asashima M, Kurisaki A, Noguchi TK, Ishimine H, Nakajima Y, Watanabe-Susaki K, Shigeta N, Yamakawa N, Wang PC, Asashima M, Kurisaki A. | 07/4/2015 |
| The sympathetic hyperactivity present in alpha2A/alpha2C-ARKO mice alters vascular reactivity only in certain types of arteries | Double disruption of α2A- and α2C-adrenoceptors induces endothelial dysfunction in mouse small arteries: role of nitric oxide synthase uncoupling.
Couto GK, Davel AP, Brum PC, Rossoni LV. | 06/20/2015 |
| Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR) signaling disrupts transgenic amyloid precursor protein (APP) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain. | α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction.
Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q., Free PMC Article | 05/2/2015 |
| local modulation of alpha-adrenergic reeptor in the ventrolateral preoptic nucleus destabilizes, but does not fully antagonize, the anesthetic state, thus priming the brain for anesthetic emergence. | α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state.
McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB., Free PMC Article | 02/21/2015 |
| alpha2A/alpha2C-adrenoceptor deletion accelerates cutaneous wound healing in mice | Deletion of the α2A/α2C-adrenoceptors accelerates cutaneous wound healing in mice.
Romana-Souza B, Nascimento AP, Brum PC, Monte-Alto-Costa A., Free PMC Article | 11/22/2014 |
| Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha1- and alpha2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress. | Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
Alves FH, Crestani CC, Resstel LB, Corrêa FM., Free PMC Article | 09/20/2014 |
| Thus, our study reveals distinct actions of PBN afferents within the BNST and suggests that alpha(2A)-AR agonists may filter excitatory transmission in the BNST by inhibiting a component of the PBN input while enhancing the actions of other inputs. | α(2A)-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis.
Flavin SA, Matthews RT, Wang Q, Muly EC, Winder DG., Free PMC Article | 09/13/2014 |
| The time course of Adra2a- and dopamine D2R-mediated transmission reflects underlying differences in the extent of spillover and pooling of inhibitory postsynaptic potentials (IPSPs). | The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.
Courtney NA, Ford CP., Free PMC Article | 08/9/2014 |
| Activation of alpha2A-AR and muscarinic M3 receptors affects the initial [Ca(2+)] response to increase of glucose from 3 to 20mM in BETA-cells. | Activation of alpha adrenergic and muscarinic receptors modifies early glucose suppression of cytoplasmic Ca(2+) in pancreatic β-cells.
Hellman B, Dansk H, Grapengiesser E. | 05/10/2014 |