| Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing. | Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing.
Veler H, Lun CM, Waheed AA, Freed EO., Free PMC Article | 10/28/2024 |
| Guanylate binding protein 5 is an immune-related biomarker of oral squamous cell carcinoma: A retrospective prognostic study with bioinformatic analysis. | Guanylate binding protein 5 is an immune-related biomarker of oral squamous cell carcinoma: A retrospective prognostic study with bioinformatic analysis.
Hasegawa M, Amano Y, Kihara A, Matsubara D, Fukushima N, Takahashi H, Chikamatsu K, Nishino H, Mori Y, Yoshida N, Niki T., Free PMC Article | 07/26/2024 |
| Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice. | Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice.
Luu LDW, Pandey A, Paramsothy S, Ngo C, Castaño-Rodríguez N, Liu C, Kamm MA, Borody TJ, Man SM, Kaakoush NO., Free PMC Article | 03/29/2024 |
| Guanylate binding protein 5 triggers NF-kappaB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma. | Guanylate binding protein 5 triggers NF-κB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma.
Chiu HW, Lin CH, Lee HH, Lu HW, Lin YK, Lin YF, Lee HL. | 02/4/2024 |
| Guanylate-binding protein 5-mediated cell-autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study. | Guanylate-binding protein 5-mediated cell-autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study.
Huang M, Zhan C, Yang B, Lu Y, Yang X, Hou J. | 01/12/2024 |
| Whole blood GBP5 protein levels in patients with and without active tuberculosis. | Whole blood GBP5 protein levels in patients with and without active tuberculosis.
Yao X, Liu W, Li X, Deng C, Li T, Zhong Z, Chen S, Ge Z, Zhang X, Zhang S, Wang Y, Liu Y, Zheng C, Ge S, Xia N., Free PMC Article | 04/9/2022 |
| GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis. | GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
Ding K, Li X, Ren X, Ding N, Tao L, Dong X, Chen Z. | 01/15/2022 |
| Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H., Free PMC Article | 11/27/2021 |
| GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway. | GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Yu X, Jin J, Zheng Y, Zhu H, Xu H, Ma J, Lan Q, Zhuang Z, Chen CC, Li M., Free PMC Article | 09/18/2021 |
| Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis. | Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis.
Haque M, Singh AK, Ouseph MM, Ahmed S., Free PMC Article | 08/14/2021 |
| GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus. | GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus.
Li Z, Qu X, Liu X, Huan C, Wang H, Zhao Z, Yang X, Hua S, Zhang W., Free PMC Article | 01/2/2021 |
| Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. | Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. | 07/4/2020 |
| the two top differentially expressed genes in our sample, IRF1 and GBP5, both have primary inflammation and immune functions, and were significantly negatively correlated with total scores on our self-report of anhedonia across all 48 subjects with cocaine-use disorder | Anhedonia in cocaine use disorder is associated with inflammatory gene expression.
Fries GR, Khan S, Stamatovich S, Dyukova E, Walss-Bass C, Lane SD, Schmitz JM, Wardle MC., Free PMC Article | 04/27/2019 |
| we identified that the LG domains of hGBP-1 and hGBP-5 build an interaction site within the hetero dimer. Our in vitro study provides mechanistic insights into the homomeric and heteromeric interactions of hGBP-1 and hGBP-5 and present useful strategies to characterise the hGBP network further. | Homo and hetero dimerisation of the human guanylate-binding proteins hGBP-1 and hGBP-5 characterised by affinities and kinetics.
Kutsch M, Ince S, Herrmann C. | 04/6/2019 |
| GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. | Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases.
Francisco NM, Fang YM, Ding L, Feng S, Yang Y, Wu M, Jacobs M, Ryffel B, Huang X. | 06/30/2018 |
| these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors | Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection.
Feng J, Cao Z, Wang L, Wan Y, Peng N, Wang Q, Chen X, Zhou Y, Zhu Y., Free PMC Article | 06/9/2018 |
| Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. | The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only.
Ince S, Kutsch M, Shydlovskyi S, Herrmann C. | 09/30/2017 |
| Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. | Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.
Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F. | 12/24/2016 |
| GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. | A real-time PCR signature to discriminate between tuberculosis and other pulmonary diseases.
Laux da Costa L, Delcroix M, Dalla Costa ER, Prestes IV, Milano M, Francis SS, Unis G, Silva DR, Riley LW, Rossetti ML., Free PMC Article | 03/26/2016 |
| guanylate binding protein 5 (GBP5) stimulates inflammasome assembly; GBP5 promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents; GBP5 serves as a unique rheostat for NLRP3 inflammasome activation | GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.
Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. | 11/24/2012 |
| The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. | Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.
Britzen-Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S, Naschberger E, Herrmann C, Stürzl M., Free PMC Article | 06/30/2011 |
| analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant | Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant.
Wehner M, Herrmann C. | 05/10/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. | Unique features of different members of the human guanylate-binding protein family.
Tripal P, Bauer M, Naschberger E, Mörtinger T, Hohenadl C, Cornali E, Thurau M, Stürzl M. | 04/3/2009 |
| 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. | Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection.
Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, Kimura H. | 01/21/2010 |