| A crucial role of adenosine deaminase in regulating gluconeogenesis in mice. | A crucial role of adenosine deaminase in regulating gluconeogenesis in mice.
Ding Z, Ge W, Xu X, Xu X, Sun Q, Xu X, Zhang J., Free PMC Article | 07/25/2024 |
| Inhibition of eADA blocked endothelial activation suggesting a crucial role of this enzyme in the control of vascular inflammation. This supports the concept of eADA targeted vascular protection therapy | Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation.
Kutryb-Zajac B, Mierzejewska P, Sucajtys-Szulc E, Bulinska A, Zabielska MA, Jablonska P, Serocki M, Koszalka P, Milczarek R, Jasztal A, Bartoszewski R, Chlopicki S, Slominska EM, Smolenski RT. | 06/20/2020 |
| Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice | Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice.
Dhanju R, Min W, Ackerley C, Cimpean L, Palaniyar N, Roifman CM, Grunebaum E. | 08/23/2014 |
| Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice | Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice.
Ray I, Sharma R. | 09/22/2012 |
| Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine. | Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.
Sauer AV, Brigida I, Carriglio N, Hernandez RJ, Scaramuzza S, Clavenna D, Sanvito F, Poliani PL, Gagliani N, Carlucci F, Tabucchi A, Roncarolo MG, Traggiai E, Villa A, Aiuti A., Free PMC Article | 04/7/2012 |
| ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation. | High levels of adenosine deaminase on dendritic cells promote autoreactive T cell activation and diabetes in nonobese diabetic mice.
Ghaemi Oskouie F, Shameli A, Yang A, Desrosiers MD, Mucsi AD, Blackburn MR, Yang Y, Santamaria P, Shi Y. | 10/8/2011 |
| The catalytic mechanism of Mus musculus adenosine deaminase (ADA) has been studied by quantum mechanics and two-layered ONIOM calculations | A theoretical study on the catalytic mechanism of Mus musculus adenosine deaminase.
Wu XH, Zou GL, Quan JM, Wu YD. | 10/23/2010 |
| Adenosine deaminase is necessary but not sufficient to confer puromycin aminonucleoside sensitivity to podocytes. | Over-expression of adenosine deaminase in mouse podocytes does not reverse puromycin aminonucleoside resistance.
Brideau G, Doucet A., Free PMC Article | 10/23/2010 |
| ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. | ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Sauer AV, Mrak E, Hernandez RJ, Zacchi E, Cavani F, Casiraghi M, Grunebaum E, Roifman CM, Cervi MC, Ambrosi A, Carlucci F, Roncarolo MG, Villa A, Rubinacci A, Aiuti A. | 01/21/2010 |
| ADA/A2B adenosine receptor double-knockout mice exhibited enhanced pulmonary inflammation and airway destruction | Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor.
Zhou Y, Mohsenin A, Morschl E, Young HW, Molina JG, Ma W, Sun CX, Martinez-Valdez H, Blackburn MR., Free PMC Article | 01/21/2010 |
| Progesterone may have an antiseizure effect with the additional finding that decreased levels of adenosine deaminase that would have resulted in increased adenosine levels that exerts anticonvulsant effect via GABA-A receptors. | Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.
Pençe S, Erkutlu I, Kurtul N, Alptekin M, Tan U. | 01/21/2010 |
| These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation. | Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice.
Mohsenin A, Mi T, Xia Y, Kellems RE, Chen JF, Blackburn MR. | 01/21/2010 |
| Transactivation by a duodenum-specific enhancer requires functional GATA4 binding sites | High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.
Dusing MR, Florence EA, Wiginton DA. | 01/21/2010 |
| ADA-deficient B cells exhibit a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, and suggest a role for ADA in the survival of cells during antigen-dependent responses. | Impaired germinal center maturation in adenosine deaminase deficiency.
Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE. | 01/21/2010 |
| This study provides a basis for investigating the folding kinetics of murine ADA and folding mechanisms of (beta/alpha)8-barrel proteins using 19F NMR sepctroscopy. | Urea-dependent unfolding of murine adenosine deaminase: sequential destabilization as measured by 19F NMR.
Shu Q, Frieden C. | 01/21/2010 |
| RUNX1 transcription factor plays a significant role in regulating Ada gene expression in the trophoblast cell lineage. | Regulation of murine Ada gene expression in the placenta by transcription factor RUNX1.
Schaubach BM, Wen HY, Kellems RE. | 01/21/2010 |
| adenosine deaminase deficient results in deoxy-ATP accumulation and leads to reduced thymic T cell production | Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation.
Van De Wiele CJ, Vaughn JG, Blackburn MR, Ledent CA, Jacobson M, Jiang H, Thompson LF., Free PMC Article | 01/21/2010 |