| In Silico Analysis Identified Putative Pathogenic Missense nsSNPs in Human SLITRK1 Gene. | In Silico Analysis Identified Putative Pathogenic Missense nsSNPs in Human SLITRK1 Gene.
Ali MZ, Farid A, Ahmad S, Muzammal M, Mohaini MA, Alsalman AJ, Al Hawaj MA, Alhashem YN, Alsaleh AA, Almusalami EM, Maryam M, Khan MA., Free PMC Article | 04/30/2022 |
| Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer. | Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer.
Guo Y, Guo XL, Wang S, Chen X, Shi J, Wang J, Wang K, Klempner SJ, Wang W, Xiao M., Free PMC Article | 05/22/2021 |
| Our results indicate an important influence of the neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in obsessive-compulsive disorder susceptibility | Gene variations in PBX1, LMX1A and SLITRK1 are associated with obsessive-compulsive disorder and its clinical features.
Melo-Felippe FB, Fontenelle LF, Kohlrausch FB. | 04/6/2019 |
| Altogether, these results demonstrate that Slitrk family proteins regulate synapse formation. | Slitrk1 is localized to excitatory synapses and promotes their development.
Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF., Free PMC Article | 04/21/2018 |
| Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome. | Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
Inai A, Tochigi M, Kuwabara H, Nishimura F, Kato K, Eriguchi Y, Shimada T, Furukawa M, Kawamura Y, Sasaki T, Kakiuchi C, Kasai K, Kano Y. | 06/28/2016 |
| the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder | Characterization of SLITRK1 variation in obsessive-compulsive disorder.
Ozomaro U, Cai G, Kajiwara Y, Yoon S, Makarov V, Delorme R, Betancur C, Ruhrmann S, Falkai P, Grabe HJ, Maier W, Wagner M, Lennertz L, Moessner R, Murphy DL, Buxbaum JD, Züchner S, Grice DE., Free PMC Article | 04/26/2014 |
| The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example. | The genetic basis of Gilles de la Tourette Syndrome.
Paschou P. | 01/11/2014 |
| One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes | Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.
Yasmeen S, Melchior L, Bertelsen B, Skov L, Mol Debes N, Tümer Z. | 10/26/2013 |
| DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression. | Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy.
Marteyn A, Maury Y, Gauthier MM, Lecuyer C, Vernet R, Denis JA, Pietu G, Peschanski M, Martinat C. | 07/30/2011 |
| The study of this study support that SLITRK1 var321 is association to Tourette syndrome. | Additional support for the association of SLITRK1 var321 and Tourette syndrome.
O'Roak BJ, Morgan TM, Fishman DO, Saus E, Alonso P, Gratacòs M, Estivill X, Teltsh O, Kohn Y, Kidd KK, Cho J, Lifton RP, State MW., Free PMC Article | 08/16/2010 |
| These findings provide the first support for the original finding indicating SLITRK1 as a susceptibility gene for Gilles de la Tourette Syndrome | Association of SLITRK1 to Gilles de la Tourette Syndrome.
Miranda DM, Wigg K, Kabia EM, Feng Y, Sandor P, Barr CL. | 01/21/2010 |
| We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. | Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene.
Pasquini M, Fabbrini G, Berardelli I, Bonifati V, Biondi M, Berardelli A. | 01/21/2010 |
| results provide no evidence for SLITRK1 playing a major role in Tourette disease | Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder.
Zimprich A, Hatala K, Riederer F, Stogmann E, Aschauer HN, Stamenkovic M, Zimprich A, Hatala K, Riederer F, Stogmann E, Aschauer HN, Stamenkovic M. | 01/21/2010 |
| identified four new variants for Gilles de la Tourette syndrome | Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome.
Speed WC, O'Roak BJ, Tárnok Z, Barta C, Pakstis AJ, State MW, Kidd KK. | 01/21/2010 |
| Observed transmission is lacking of SLITRK1 var321 from an affected parent to a child with Tourette syndrome in two families segregating this variant. | Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample.
Scharf JM, Moorjani P, Fagerness J, Platko JV, Illmann C, Galloway B, Jenike E, Stewart SE, Pauls DL, Tourette Syndrome International Consortium for Genetics., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesCoeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder.
Zimprich A, Hatala K, Riederer F, Stogmann E, Aschauer HN, Stamenkovic M, Zimprich A, Hatala K, Riederer F, Stogmann E, Aschauer HN, Stamenkovic M. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region.
Miranda DM, Wigg K, Feng Y, Sandor P, Barr CL. | 03/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | See all PubMed (3) articlesExamination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.
Deng H, Le WD, Xie WJ, Jankovic J. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses.
Keen-Kim D, Mathews CA, Reus VI, Lowe TL, Herrera LD, Budman CL, Gross-Tsur V, Pulver AE, Bruun RD, Erenberg G, Naarden A, Sabatti C, Freimer NB. Sequence variants in SLITRK1 are associated with Tourette's syndrome.
Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW, Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. | 03/13/2008 |
| Genetic screening in the Slit and Trk-like 1 gene for the recently identified mutations does not appear to be of utility in the diagnosis of Tourette syndrome. | Association of the Slit and Trk-like 1 gene in Taiwanese patients with Tourette syndrome.
Chou IC, Wan L, Liu SC, Tsai CH, Tsai FJ. | 01/21/2010 |
| negative results of the SLITRK1 analysis point to genetic heterogeneity in Tourette syndrome | A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene.
Fabbrini G, Pasquini M, Aurilia C, Berardelli I, Breedveld G, Oostra BA, Bonifati V, Berardelli A. | 01/21/2010 |
| findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome | Sequence variants in SLITRK1 are associated with Tourette's syndrome.
Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW, Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. | 01/21/2010 |
| No variation in patients susceptible to obsessive-compulsive disorder.( | Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder.
Wendland JR, Kruse MR, Murphy DL. | 01/21/2010 |
| SLITRK1 trouble in Tourette's syndrome. | SLITRK1 trouble in Tourette's syndrome.
Burton A. | 01/21/2010 |
| Rare variations in SLITRK1 result in disorders of the obsessive-complusive disease spectrum | SLITRK1 mutations in trichotillomania.
Zuchner S, Cuccaro ML, Tran-Viet KN, Cope H, Krishnan RR, Pericak-Vance MA, Wright HH, Ashley-Koch A. | 01/21/2010 |