| Deletion of exons 2 and 3 from Actb and cell immortalization lead to widespread, beta-actin independent alterations in gene expression associated with cell cycle control. | Deletion of exons 2 and 3 from Actb and cell immortalization lead to widespread, β-actin independent alterations in gene expression associated with cell cycle control.
Sundby LJ, Southern WM, Sun J, Patrinostro X, Zhang W, Yong J, Ervasti JM. | 07/19/2024 |
| Knockdown of AK142426 suppresses M2 macrophage polarization and inflammation in peritoneal fibrosis via binding to c-Jun. | Knockdown of AK142426 suppresses M2 macrophage polarization and inflammation in peritoneal fibrosis via binding to c-Jun.
Shao Q, Jiang C, Zhang Q, Liu J, Jin B, Zhao M, Xia Y. | 09/8/2023 |
| Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation. | Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation.
Cornelius J, Rottner K, Korte M, Michaelsen-Preusse K., Free PMC Article | 10/30/2021 |
| Mitochondria-localized beta-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability. | Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability.
Xie X, Endara-Coll M, Mahmood R, Jankauskas R, Gjorgjieva T, Percipalle P., Free PMC Article | 08/29/2020 |
| Our data suggest that targeted disruption of L-plastin increases trabecular bone volume, and phosphorylation of Ser5 in L-plastin in the Lrrk1 signaling pathway may in part contribute to actin assembly in mature osteoclasts. | LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin.
Si M, Goodluck H, Zeng C, Pan S, Todd EM, Morley SC, Qin X, Mohan S, Xing W., Free PMC Article | 11/30/2019 |
| In beta-actin null cells, we show evidence that the enhanced TGF-b signaling relies on the active utilization of latent TGF-b1 in the cell culture medium. TGF-b signaling activation contributes to the elevated reactive oxygen species production, which is likely mediated by the upregulation of Nox4. | Elevated transforming growth factor β signaling activation in β-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features.
Xie X, Percipalle P., Free PMC Article | 09/28/2019 |
| our work reveals fundamental differences in the role of the cortical beta-actin cytoskeleton in mature muscle compared with cell culture | β-Actin shows limited mobility and is required only for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle.
Madsen AB, Knudsen JR, Henriquez-Olguin C, Angin Y, Zaal KJ, Sylow L, Schjerling P, Ralston E, Jensen TE., Free PMC Article | 07/6/2019 |
| Data, including data from studies using knockout mice, suggest that Actb and Actg1 are enriched in isolated membrane preparations from skeletal muscle which represent interface between mitochondria and sarco-endoplasmic reticulum; these structures appear to be important in signaling, mitochondrial dynamics, and muscle relaxation. (Actb = beta actin cytoplasmic 1; Actg1 = actin gamma cytoplasmic 1) | Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.
O'Rourke AR, Lindsay A, Tarpey MD, Yuen S, McCourt P, Nelson DM, Perrin BJ, Thomas DD, Spangenburg EE, Lowe DA, Ervasti JM., Free PMC Article | 12/22/2018 |
| Essential nucleotide- and protein-dependent functions of Actb/beta-actin. | Essential nucleotide- and protein-dependent functions of Actb/β-actin.
Patrinostro X, Roy P, Lindsay A, Chamberlain CM, Sundby LJ, Starker CG, Voytas DF, Ervasti JM, Perrin BJ., Free PMC Article | 09/22/2018 |
| These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation. | In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects.
Almuzzaini B, Sarshad AA, Rahmanto AS, Hansson ML, Von Euler A, Sangfelt O, Visa N, Farrants AK, Percipalle P. | 08/26/2017 |
| Two actin isoforms, beta- and gamma-actin, are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses. | Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.
Wu XS, Lee SH, Sheng J, Zhang Z, Zhao WD, Wang D, Jin Y, Charnay P, Ervasti JM, Wu LG., Free PMC Article | 07/22/2017 |
| Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin. | Microarray and gene co-expression analysis reveals that melatonin attenuates immune responses and modulates actin rearrangement in macrophages.
Kadena M, Kumagai Y, Vandenbon A, Matsushima H, Fukamachi H, Maruta N, Kataoka H, Arimoto T, Morisaki H, Funatsu T, Kuwata H. | 06/24/2017 |
| Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration. | Specific interaction of KIF11 with ZBP1 regulates the transport of β-actin mRNA and cell motility.
Song T, Zheng Y, Wang Y, Katz Z, Liu X, Chen S, Singer RH, Gu W., Free PMC Article | 12/26/2015 |
| TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. | Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.
Carrascoso I, Sánchez-Jiménez C, Izquierdo JM., Free PMC Article | 01/17/2015 |
| Actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the beta-actin knock-out cells and many of these contain CH-, LIM- or EFh- domains. | β-Actin knock-out mouse embryonic fibroblasts show increased expression of LIM-, CH-, EFh-domain containing proteins with predicted common upstream regulators.
Ampe C, Libbrecht J, Van Troys M. | 10/25/2014 |
| Absence of beta-actin severely hampers formation of the peripheral nervous system, due to defective neural crest migration. | Beta-actin is required for proper mouse neural crest ontogeny.
Tondeleir D, Noelanders R, Bakkali K, Ampe C., Free PMC Article | 09/20/2014 |
| Data indicate that ectopic phosphatidylinositol 3,4,5-triphosphate (PIP3) elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like "waves". | Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis.
Kakumoto T, Nakata T., Free PMC Article | 08/23/2014 |
| this work demonstrated that dendritic beta-actin messenger RNA and ribosomes are in a masked, neuron-specific form. | Single β-actin mRNA detection in neurons reveals a mechanism for regulating its translatability.
Buxbaum AR, Wu B, Singer RH., Free PMC Article | 03/1/2014 |
| chorein interacts with beta-adducin and beta-actin. | Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin.
Shiokawa N, Nakamura M, Sameshima M, Deguchi A, Hayashi T, Sasaki N, Sano A. | 01/18/2014 |
| RNA polymerase II, glyceraldehyde-3-phosphate dehydrogenase (Gapdh), and hypoxanthine phophoribosyltransferase (Hprt) show a more stable gene expression as candidate genes than do ribosomal 18s and Actb. | Reference genes in the developing murine brain and in differentiating embryonic stem cells.
Kraemer N, Neubert G, Issa L, Ninnemann O, Seiler AE, Kaindl AM. | 06/15/2013 |
| The findings suggested that local translation of beta-actin in growth cones of motoneurons is regulated by laminin signalling and that this signalling is disturbed in survival of motoneuron protein-deficient motoneurons. | Laminin induced local axonal translation of β-actin mRNA is impaired in SMN-deficient motoneurons.
Rathod R, Havlicek S, Frank N, Blum R, Sendtner M. | 04/6/2013 |
| Data suggest that in beta-actin knockout cells other actins compensate for beta-actin in cell migration process. | Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity.
Tondeleir D, Lambrechts A, Müller M, Jonckheere V, Doll T, Vandamme D, Bakkali K, Waterschoot D, Lemaistre M, Debeir O, Decaestecker C, Hinz B, Staes A, Timmerman E, Colaert N, Gevaert K, Vandekerckhove J, Ampe C., Free PMC Article | 12/22/2012 |
| Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell. | Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes.
Albershardt TC, Iritani BM, Ruddell A., Free PMC Article | 12/8/2012 |
| the zipcode-binding protein 1 transports beta-actin mRNA to the focal adhesion compartment, it dwells for minutes, associating its localization with motility through the formation of stable connections between adhesions and newly synthesized actin filaments | β-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration.
Katz ZB, Wells AL, Park HY, Wu B, Shenoy SM, Singer RH., Free PMC Article | 11/17/2012 |
| These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. | Trichinella spiralis infection induces β-actin co-localized with thymosin β4.
Kang YJ, Jo JO, Cho MK, Yu HS, Cha HJ, Ock MS. | 10/27/2012 |