| C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans. | C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans.
Bachmann JC, Kirchhoff JE, Napolitano JE, Sorota S, Gordon WM, Feric N, Aschar-Sobbi R, Lv J, Cao Z, Coppieters K, Borghetti G, Nyberg M., Free PMC Article | 04/17/2024 |
| CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. | CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors.
Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW., Free PMC Article | 05/21/2022 |
| C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro. | C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro.
Chen WX, Liu HH, Li RX, Mammadov G, Wang JJ, Liu FF, Samadli S, Wu YF, Zhang DD, Luo HH, Hu P., Free PMC Article | 04/13/2021 |
| CNP-KO rats might be a valuable animal model for investigating growth plate physiology and the mechanism of growth plate closure. | Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats.
Hirota K, Furuya M, Morozumi N, Yoshikiyo K, Yotsumoto T, Jindo T, Nakamura R, Murakami K, Ueda Y, Hanada T, Sade H, Yoshida S, Enomoto K, Kanai Y, Yamauchi I, Yamashita T, Ueda-Sakane Y, Fujii T, Yasoda A, Inagaki N., Free PMC Article | 03/9/2019 |
| C-type Natriuretic Peptide Knock-out rats survive over one year, and exhibit a deficit in endochondral bone growth and growth retardation throughout life. | Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
Fujii T, Hirota K, Yasoda A, Takizawa A, Morozumi N, Nakamura R, Yotsumoto T, Kondo E, Yamashita Y, Sakane Y, Kanai Y, Ueda Y, Yamauchi I, Yamanaka S, Nakao K, Kuwahara K, Jindo T, Furuya M, Mashimo T, Inagaki N, Serikawa T, Nakao K., Free PMC Article | 07/28/2018 |
| Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats. | Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
Lu J, Pan SS., Free PMC Article | 03/24/2018 |
| C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation. | C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, Özcelik C, Paterson DJ, Bader M, Herring N., Free PMC Article | 10/14/2017 |
| A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia. | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia.
Demirtas S, Karahan O, Yazici S, Guclu O, Caliskan A, Tezcan O, Yavuz C., Free PMC Article | 10/3/2015 |
| The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. Xiaoyaosan antagonizes this pathway at least partially. | CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.
Li P, Tang XD, Cai ZX, Qiu JJ, Lin XL, Zhu T, Owusu L, Guo HS., Free PMC Article | 09/26/2015 |
| the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP. | Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy.
Hu P, Zhao XQ, Wang J, Kong HB, Hu B, Lu L, Qin YH. | 08/15/2015 |
| Study findings suggest that CNP could ameliorate ischemia-reperfusion-induced acute kidney injury through inhibition of apoptotic and oxidative stress pathways, possibly through natriuretic peptide receptor-B-cGMP signaling | C-type natriuretic peptide ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting apoptosis and oxidative stress in rats.
Jin X, Zhang Y, Li X, Zhang J, Xu D. | 01/31/2015 |
| We conclude that CNP-induced phospholamban and troponin I phosphorylation by protein kinase G in concert mediate both a predictable positive lusitropic responses as well as the less expected negative inotropic in failing hearts | SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Moltzau LR, Aronsen JM, Meier S, Nguyen CH, Hougen K, Ørstavik Ø, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E., Free PMC Article | 09/13/2014 |
| These preliminary data give new insights into the relationship between natriuretic peptide signaling and sKATP in the myocardium. | Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes.
Burley DS, Cox CD, Zhang J, Wann KT, Baxter GF., Free PMC Article | 09/13/2014 |
| results suggest that cGMP-PDE3-cAMP signal pathway is also involved in the CNP-induced inhibition of gastric motility in rat | cGMP-PDE3-cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat.
Cai YL, Sun Q, Huang X, Jiang JZ, Zhang MH, Piao LH, Jin Z, Xu WX. | 06/15/2013 |
| Expression of C-type natriuretic peptide (CNP) in cardiac cells at gene and protein levels suggests that the heart is actively involved in the production of CNP. | Expression of C-type natriuretic peptide and its receptor NPR-B in cardiomyocytes.
Del Ry S, Cabiati M, Vozzi F, Battolla B, Caselli C, Forini F, Segnani C, Prescimone T, Giannessi D, Mattii L. | 02/25/2012 |
| urinary C-type natriuretic peptide could potentially aid in identifying subjects with preclinical structural changes before the onset of symptoms and disease | Urinary C-type natriuretic peptide excretion: a potential novel biomarker for renal fibrosis during aging.
Sangaralingham SJ, Heublein DM, Grande JP, Cataliotti A, Rule AD, McKie PM, Martin FL, Burnett JC Jr., Free PMC Article | 12/17/2011 |
| The gene expression levels of CNP/NPR-B in rat testes at different postnatal stages and in infertile testes indicated that CNP may participate in the physiology and/or pathology related to spermatogenesis. | The role of C-type natriuretic peptide in rat testes during spermatogenesis.
Huang DH, Zhang SW, Zhao H, Zhang L., Free PMC Article | 07/16/2011 |
| Data show that a progressive decline in circulating CNP characterizes natural aging and is strongly associated with a reciprocal increase in LV fibrosis that precedes impairment of diastolic and systolic function. | The aging heart, myocardial fibrosis, and its relationship to circulating C-type natriuretic Peptide.
Sangaralingham SJ, Huntley BK, Martin FL, McKie PM, Bellavia D, Ichiki T, Harders GE, Chen HH, Burnett JC Jr., Free PMC Article | 04/23/2011 |
| CNP is involved in the regulation of bidirectional plasticity in area CA1 potentially by modulating GABA(A)-mediated inhibition and NMDA receptors. | C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro.
Decker JM, Wójtowicz AM, Bartsch JC, Liotta A, Braunewell KH, Heinemann U, Behrens CJ. | 03/5/2011 |
| The plasma levels of urotensin II, NO, and C-type natriuretic peptide in rats with hypoxia-induced pulmonary hypertension were higher than those in the control group. | [The expression and significance of urotensin II, nitric oxide, and C-type natriuretic peptide in hypoxia-induced pulmonary hypertension in rats].
Sun DJ, Yang JP, Sun YH. | 09/13/2010 |
| Depression of CNP-dependent cGMP-mediated [Ca2+]i accumulation may contribute to cerebral vascular endothelial dysfunction associated with hyperammonemia or hepatic encephalopathy. | Ammonia inhibits the C-type natriuretic peptide-dependent cyclic GMP synthesis and calcium accumulation in a rat brain endothelial cell line.
Konopacka A, Zielińska M, Albrecht J. | 01/21/2010 |
| Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. | Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C. | 01/21/2010 |
| pituitary adenylate cyclase-activating polypeptide might be involved in the regulation of C-type natriuretic peptide biosynthesis in astrocytes | C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes.
Fujikawa K, Nagayama T, Inoue K, Minamino N, Kangawa K, Niiro M, Miyata A. | 01/21/2010 |
| CNP produced by cardiac fibroblasts may play a role as an autocrine regulator against excessive cardiac fibrosis. | Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts.
Horio T, Tokudome T, Maki T, Yoshihara F, Suga S, Nishikimi T, Kojima M, Kawano Y, Kangawa K. | 01/21/2010 |
| Endothelium-derived CNP is involved in the regulation of the coronary circulation, and NPR-C activation underlies the vasorelaxant activity of this peptide. Moreover, this newly defined pathway represents a protective mechanism against I/R injury. | Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.
Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A. | 01/21/2010 |