| The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans. | The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans.
Nies AT, Weiss S, Schaeffeler E, Hannemann A, Völker U, Wallaschofski H, Schwab M., Free PMC Article | 06/5/2021 |
| Large interindividual variability was noted in the hepatic expression of OAT2 (16-fold in human liver tissue and 23-fold in hepatocytes). OAT7, on the other hand, showed less interindividual variability (4-fold) in the livers, but high variability for the hepatocyte lots (27-fold). A significant positive correlation in OAT2 and OAT7 expression was observed, but expression levels were neither associated with age nor sex. | Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.
Vildhede A, Kimoto E, Rodrigues AD, Varma MVS. | 07/27/2019 |
| two human organic anion transporters OAT2 and OAT7 activities were assessed. | In vitro studies with two human organic anion transporters: OAT2 and OAT7.
Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD. | 11/17/2018 |
| Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha, may contribute to pravastatin drug disposition and might affect response. | Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.
Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT. | 03/11/2017 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid. | Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid.
Nakagawa H, Terada T, Harada KH, Hitomi T, Inoue K, Inui K, Koizumi A. | 01/21/2010 |
| The data provide a model for the concerted action of OAT1 mediating apical secretion of glutarate derivatives from proximal tubule cells | Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias.
Hagos Y, Krick W, Braulke T, Mühlhausen C, Burckhardt G, Burckhardt BC. | 01/21/2010 |
| Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported. | Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta.
Ugele B, Bahn A, Rex-Haffner M. | 01/21/2010 |
| Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC22) member 9. | Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.
Zaïr ZM, Eloranta JJ, Stieger B, Kullak-Ublick GA. | 01/21/2010 |
| The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4. | Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.
Ogasawara K, Terada T, Motohashi H, Asaka JI, Aoki M, Katsura T, Kamba T, Ogawa O, Inui KI. | 01/21/2010 |
| Both progesterone and activation of PKC inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments. | Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells.
Zhou F, Hong M, You G. | 01/21/2010 |
| uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates. | Characterization and identification of steroid sulfate transporters of human placenta.
Ugele B, St-Pierre MV, Pihusch M, Bahn A, Hantschmann P. | 01/21/2010 |
| OAT7 is the first liver-specific transporter among members of the organic anion transporters of SLC22 family. | Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate.
Shin HJ, Anzai N, Enomoto A, He X, Kim DK, Endou H, Kanai Y. | 01/21/2010 |