| Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model. | Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model.
Zeng X, Mai J, Xie H, Yang L, Liu X., Free PMC Article | 04/26/2023 |
| Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain. | Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain.
Lei X, Yan Y, Zeng J, Wang R, Li S, Xiao Z, Liu X. | 01/14/2023 |
| Decreased Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Activity in a Rat Model of Absence Epilepsy and the Effect of ZD7288, an Ih Inhibitor, on the Spike-and-Wave Discharges. | Decreased Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Activity in a Rat Model of Absence Epilepsy and the Effect of ZD7288, an Ih Inhibitor, on the Spike-and-Wave Discharges.
Yavuz M, Aydın B, Çarçak N, Onat F. | 03/12/2022 |
| Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype. | Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype.
Singh N, Zabbarova I, Ikeda Y, Kanai A, Chermansky C, Yoshimura N, Tyagi P., Free PMC Article | 01/15/2022 |
| Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy. | Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy.
Hadova K, Kralova E, Doka G, Bies Pivackova L, Kmecova Z, Krenek P, Klimas J., Free PMC Article | 10/9/2021 |
| HCN2 contributes to oxaliplatin-induced neuropathic pain by inducing spinal long-term potentiation via activation of NMDA receptor-mediated CaMKII signaling. | HCN2 contributes to oxaliplatin-induced neuropathic pain by inducing spinal long-term potentiation via activation of NMDA receptor-mediated CaMKII signaling.
Liu X, Ji Q, Liu F, Jin L, Tan Y, Zhang L, Tang J. | 09/4/2021 |
| Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95. | Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.
Zhang X, Li X, Wang H, Xie X, Li Y, Xu X, Su S, Zhao H, Li J, Ke C, Liu J. | 06/19/2021 |
| The present study provided evidence that SK4 and HCN2 combined could construct an ectopic pacemaker, laying the groundwork for the development of improved biological pacing mechanisms in the future. | Overexpression of the medium‑conductance calcium‑activated potassium channel (SK4) and the HCN2 channel to generate a biological pacemaker.
Zhao H, Yang M, Wang F, Yang A, Zhao Q, Wang X, Tang Y, Wang T, Huang C. | 02/8/2020 |
| HCN2 is conducive to oxaliplatin-induced neuropathic pain by activating the neuronal CaMKII/CREB cascade. | HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons.
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J., Free PMC Article | 10/27/2018 |
| Hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 protein expression levels were increased in the thalamus under chronic pain condition. Results suggest, increased HCN channel activity in the thalamus of the ascending nociceptive pathway contributes to both chronic neuropathic and inflammatory pain conditions. | Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats.
Ding W, You Z, Shen S, Chen L, Zhu S, Mao J., Free PMC Article | 07/29/2017 |
| Data suggest that HCN channels might play an important role in affecting contraction frequency of lymphatic muscle cells. | Hyperpolarization-activated cyclic nucleotide-gated channels in peripheral diaphragmatic lymphatics.
Negrini D, Marcozzi C, Solari E, Bossi E, Cinquetti R, Reguzzoni M, Moriondo A. | 07/1/2017 |
| the expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described. | Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
Zúñiga R, González D, Valenzuela C, Brown N, Zúñiga L. | 06/3/2017 |
| During the senescent process, the HCN2 and HCN4 protein levels declined. | Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Huang X, Yang P, Yang Z, Zhang H, Ma A., Free PMC Article | 06/11/2016 |
| Spatial learning and memory deficits in the chronic cerebral hypoperfusion model are associated with disturbed HCN1 and HCN2 surface expression in hippocampal CA1. | Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region.
Luo P, Lu Y, Li C, Zhou M, Chen C, Lu Q, Xu X, He Z, Guo L. | 05/28/2016 |
| These results suggest that HCN2 in the subthalamic nucleus is involved in abnormal oscillation regulation between Motor cortex and globus pallidus . | Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats.
Yang C, Zhang JR, Chen L, Ge SN, Wang JL, Yan ZQ, Jia D, Zhu JL, Gao GD. | 04/30/2016 |
| Spironolactone increased miRNA-1 expression in myocardium after myocardial infarction. Upregulation of miRNA-1 expression contributed to the posttranscriptional repression of HCN2/4 expression. | Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.
Yu HD, Xia S, Zha CQ, Deng SB, Du JL, She Q., Free PMC Article | 03/12/2016 |
| The results suggest that peripheral HCN2 channels contribute to mechanisms of spinal nerve injury-induced peripheral neuropathic pain. | Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
Smith T, Al Otaibi M, Sathish J, Djouhri L. | 01/16/2016 |
| This study demonstrated that HCN2 contribute to heat hypersensitivity and ongoing activity in the neuritis model. | Contribution of hyperpolarization-activated channels to heat hypersensitivity and ongoing activity in the neuritis model.
Richards N, Dilley A. | 12/26/2015 |
| Results suggest that HCN1 and HCN2 are expressed mainly by both the soma of mechanosensitive neurons in the trigeminal ganglion and peripheral axons of nociceptive neurons in the sensory root | The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, and dental pulp.
Cho YS, Kim YS, Moozhayil SJ, Yang ES, Bae YC. | 12/26/2015 |
| Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area | Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion.
Li CJ, Lu Y, Zhou M, Zong XG, Li C, Xu XL, Guo LJ, Lu Q. | 09/12/2015 |
| Overexpression of HCN-2 channels in ventral tegmental area increases voluntary ethanol intake. | Overexpression of hyperpolarization-activated cyclic nucleotide-gated channels into the ventral tegmental area increases the rewarding effects of ethanol in UChB drinking rats.
Rivera-Meza M, Quintanilla ME, Bustamante D, Delgado R, Buscaglia M, Herrera-Marschitz M. | 12/20/2014 |
| Significant reductions in cardiac HCN2 mRNA and protein expression are demonstrated in genetic absence epilepsy rat-strain and acquired-epilepsy models. | HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models.
Powell KL, Jones NC, Kennard JT, Ng C, Urmaliya V, Lau S, Tran A, Zheng T, Ozturk E, Dezsi G, Megatia I, Delbridge LM, Pinault D, Reid CA, White PJ, O'Brien TJ. | 07/5/2014 |
| Data indicate that Gja1, Cav3 and Kcnk3 were up-regulated and Hcn2 was down-regulated in hearts of exercise trained Goto-Kakizaki (GK) type 2 diabetic rat compared to sedentary GK controls. | Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats.
Salem KA, Qureshi MA, Sydorenko V, Parekh K, Jayaprakash P, Iqbal T, Singh J, Oz M, Adrian TE, Howarth FC. | 02/8/2014 |
| Data indicate that HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins. | HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG., Free PMC Article | 01/26/2013 |
| HCN2 channels contribute to inflammation-induced C-nociceptor hyperexcitability in chronic inflammatory pain. | Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors.
Weng X, Smith T, Sathish J, Djouhri L. | 09/15/2012 |