| COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20. | COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20.
Han SH, Kim YH, Park SJ, Cho JG, Shin YK, Hong YB, Yun J, Han JY, Park HT, Park JI. | 06/2/2023 |
| pregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future | Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.
Niu RN, Shang XP, Teng JF. | 09/29/2018 |
| Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. | EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells.
Jin H, Won M, Shin E, Kim HM, Lee K, Bae J. | 06/3/2017 |
| The upregulation of Egr-2 may be involved in the subsequent glia cellular activation. | Involvement of early growth response-2 (Egr-2) in lipopolysaccharide-induced neuroinflammation.
Yan Y, Tan X, Wu X, Shao B, Wu X, Cao J, Xu J, Jin W, Li L, Xu W, Wang X, Gao Y, Cui G. | 03/29/2014 |
| in Schwann cells NFAT upregulation of Krox-20 requires elevation of cAMP levels. | Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP.
Kipanyula MJ, Woodhoo A, Rahman M, Payne D, Jessen KR, Mirsky R., Free PMC Article | 07/20/2013 |
| our results show that p38 primarily directs Schwann cell differentiation and peripheral myelination by regulating Krox-20 expression through its downstream effectors, MK2 and MSK-1/CREB, and transcription factors SCIP and Sox10. | Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination.
Hossain S, de la Cruz-Morcillo MA, Sanchez-Prieto R, Almazan G. | 09/22/2012 |
| changes in transcription factor, c-Jun and krox-20, and integrin beta4 expression are temporally correlated with the process of demyelination, suggesting roles in regulating the myelin response to CNC injury | c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.
Pham K, Nassiri N, Gupta R., Free PMC Article | 01/21/2010 |
| IEG c-fos is unaffected by suppression of calcineurin activity, the plasticity-related genes Egr1/Zif268 and Egr2/Krox-20 are up-regulated, and genes encoding the orphan nuclear hormone receptors Nor1 and Nur77 are down-regulated. | Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.
Lam BY, Zhang W, Enticknap N, Haggis E, Cader MZ, Chawla S., Free PMC Article | 01/21/2010 |
| Egr2 directly represses genes during myelination in conjunction with NAB corepressors | Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
Mager GM, Ward RM, Srinivasan R, Jang SW, Wrabetz L, Svaren J., Free PMC Article | 01/21/2010 |
| Data demonstrate that in rat Schwann cells, progesterone and its derivatives increase expression of Sox-10 and Krox-20, two transcription factors with a key role in Schwann cell physiology and myelination. | Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.
Magnaghi V, Ballabio M, Roglio I, Melcangi RC. | 01/21/2010 |
| the role of Krox-20 is to amplify an earlier Krox-20-independent activation of the periaxin gene in schwann cells | Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells.
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Duran Alonso MB, Mirsky R, Jessen KR. | 01/21/2010 |
| Housing in an enriched environment increased Krox-20 mRNA expression exclusively during the dark period of the day. | Diurnal effects of enriched environment on immediate early gene expression in the rat brain.
Rönnbäck A, Dahlqvist P, Bergström SA, Olsson T. | 01/21/2010 |
| insulin treatment rapidly increased transcription of both Egr-1 and Krox20 in hepatic cells | Insulin-regulated expression of Egr-1 and Krox20: dependence on ERK1/2 and interaction with p38 and PI3-kinase pathways.
Keeton AB, Bortoff KD, Bennett WL, Franklin JL, Venable DY, Messina JL. | 01/21/2010 |
| Egr2 mutant (S382R, D383Y), when expressed in Schwann cells in vitro, is not transcriptionally inactive but retains residual wild-type Egr2 functions | A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy.
Arthur-Farraj P, Mirsky R, Parkinson DB, Jessen KR. | 01/21/2010 |