| Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy. | Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy.
Jiang G, Shi LF, Li LJ, Duan XJ, Zheng ZF. | 02/7/2024 |
| The Relationship of p62 Gene Expression with Integrity of Mitochondrial DNA and the Level of Lipid Peroxidation Products in Skeletal Muscles of Rats of Different Ages Exposed to Different Feeding Protocols. | The Relationship of p62 Gene Expression with Integrity of Mitochondrial DNA and the Level of Lipid Peroxidation Products in Skeletal Muscles of Rats of Different Ages Exposed to Different Feeding Protocols.
Chernyshova EV, Gureev AP, Sadovnikova IS, Plotnikov EY, Silachev DN, Zorov DB, Popov VN. | 09/8/2023 |
| MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro. | MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro.
Zeng T, Zhang S, He Y, Liu Z, Cheng Q. | 04/16/2022 |
| Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. | Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells.
Feng X, Chen L, Guo W, Zhang Y, Lai X, Shao L, Li Y. | 07/6/2019 |
| Data suggest that neuroprotection via ghrelin involves up-regulation of Bcl-2 (B cell lymphoma 2 associated oncogene) and p-62/Sqstm1 (ubiquitin-binding protein p62) plus down-regulation of LC3-II (microtubule-associated protein 1 light chain 3) and Beclin-1. Studies were conducted in adult hippocampal neural stem cells in primary culture. | Ghrelin protects adult rat hippocampal neural stem cells from excessive autophagy during oxygen-glucose deprivation.
Chung H, Choi J, Park S. | 08/18/2018 |
| Quantifying autophagy using novel LC3B and p62 TR-FRET assays. | Quantifying autophagy using novel LC3B and p62 TR-FRET assays.
Bresciani A, Spiezia MC, Boggio R, Cariulo C, Nordheim A, Altobelli R, Kuhlbrodt K, Dominguez C, Munoz-Sanjuan I, Wityak J, Fodale V, Marchionini DM, Weiss A., Free PMC Article | 07/14/2018 |
| Data suggest that phosphorylation of Sqstm1 by AMP-activated protein kinase (AMPK) and translocation of Sqstm1 to mitochondria drives autophagic cell death in adult hippocampal neural stem cells; activation of AMPK promotes autophagic cell death; inhibition of AMPK (by enzyme inhibitor or RNA interference) suppresses autophagic cell death. (Sqstm1 = sequestosome 1) | Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells.
Ha S, Jeong SH, Yi K, Chung KM, Hong CJ, Kim SW, Kim EK, Yu SW., Free PMC Article | 09/9/2017 |
| p62 overexpression resulted in a progressive and robust pathology model with neuronal inclusions and neurodegeneration. | p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration.
Jackson KL, Lin WL, Miriyala S, Dayton RD, Panchatcharam M, McCarthy KJ, Castanedes-Casey M, Dickson DW, Klein RL., Free PMC Article | 08/12/2017 |
| High glucose upregulates autophagy but accumulates p62/SQTSM1 cargo due to lysosomal dysfunction, leading to massive VEGF release and cell death of rMCs. Lysosomal impairment and autophagic dysfunction are early events present in the pathogenesis of diabetic retinopathy (DR). | Defective Autophagy in Diabetic Retinopathy.
Lopes de Faria JM, Duarte DA, Montemurro C, Papadimitriou A, Consonni SR, Lopes de Faria JB. | 05/27/2017 |
| Parkin protects PC12 cells against 6-hydroxydopamine - induced apoptosis via ubiquitinating and stabilizing scaffold protein p62, and repressing ERK1/2 activation. | Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells.
Hou XO, Si JM, Ren HG, Chen D, Wang HF, Ying Z, Hu QS, Gao F, Wang GH., Free PMC Article | 08/20/2016 |
| TNF-alpha stimulates p62 accumulation and enhances proteasome activity independently of reactive oxygen species. | Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS.
Opperman CM, Sishi BJ. | 01/16/2016 |
| Upregulation of p62 may be involved in TNF-induced axonal degeneration and that decreased p62 levels may lead to axonal protection. | Axonal protection by modulation of p62 expression in TNF-induced optic nerve degeneration.
Kojima K, Kitaoka Y, Munemasa Y, Hirano A, Sase K, Takagi H. | 06/20/2015 |
| The results indicate that in a p62-dependent fashion, autophagic-lysosomal pathway inhibition impairs cardiac ubiquitin-proteasome system proteolytic performance in cardiomyocytes in vitro and in vivo. | Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes.
Tian Z, Wang C, Hu C, Tian Y, Liu J, Wang X., Free PMC Article | 03/7/2015 |
| The levels of p62/SQSTM1 and polyubiquitin aggregates, representing the function of autophagy and proteasomal degradation, increased in older kidneys. | Age-related changes in the function of autophagy in rat kidneys.
Cui J, Bai XY, Shi S, Cui S, Hong Q, Cai G, Chen X., Free PMC Article | 07/28/2012 |
| the function of p62/SQSTM1 in the proteasomal pathway and autophagy | Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
Myeku N, Figueiredo-Pereira ME., Free PMC Article | 09/3/2011 |
| The scaffold protein p62 that delivers polyubiquitinated proteins to autophagy may have a protective role against human-IAPP-induced apoptosis. | Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions.
Rivera JF, Gurlo T, Daval M, Huang CJ, Matveyenko AV, Butler PC, Costes S., Free PMC Article | 06/4/2011 |
| Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. | Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Grasso D, Ropolo A, Lo Ré A, Boggio V, Molejón MI, Iovanna JL, Gonzalez CD, Urrutia R, Vaccaro MI., Free PMC Article | 05/14/2011 |
| Data show that p38 activation induces PPARalpha phosphorylation and inhibition of its transcriptional activity through a trimeric interaction between p38-MAPK, ZIP/p62 and PPARalpha. | Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK.
Diradourian C, Le May C, Caüzac M, Girard J, Burnol AF, Pégorier JP. | 01/21/2010 |
| p62 regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination | The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.
Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J. | 01/21/2010 |